John has dog problems with just about everyone: Greeley, over a magazine piece about his childhood family pet who bit people; Ellen, who makes him sleep on the couch after an argument about animals' eyes; and Lydia, who wants a new puppy. Then Christabel, the family's ancient poodle, becomes ill, and everyone seems to hold John at fault.

When Lydia comes down with a bad cold, John takes the opportunity to try to show her that people with vivid imaginations are better off than those who approach life from a more ""realistic"" point of view. The story of ""The Unicorn in the Garden"" doesn't seem to work, so John relates the story of his great-grandfather, who not only was a prolific storyteller but managed to get the fire department called out when he was trying to attend to young John's sniffles.

After Greeley once again fails to understand the humor in one of John's cartoons, John quits his job with The Manhattanite and returns home, where he begins to wonder what he'll do for money now. He settles on playing the stock market and fantasizes about a meeting with J.P. Morgan.

John, finding himself bothered by the ordinariness of his life, fantasizes about being involved in a tale of espionage involving pickle forks and a malevolent dragon.

Greeley rejects yet another of John's cartoons which he doesn't understand, one involving a seal in the bedroom of a married couple. Ellen and Lydia agree with Greeley, and when John tells Phil about his problem, Phil suggests the seal might represent John's mother who is visiting the Monroes. Naturally this provokes a fantasy in which John's mother, who showed up at the house wearing a sealskin coat, actually becomes a seal.

After being bitten by the family cat, Dimity Ann, John takes her away and leaves her in a new housing developement. Lydia believes the cat ran away because of a dislike for her, while Ellen's suspicions come nearer the truth. John fantasizes about being on trial before a real judge for his ""crime.""

The Monroe's new neighbor, Paul Morton, who is also a cartoonist, challenges John's more sophisticated humor by pitting him against the town's answer to Will Rogers, Zeph Leggin. To John's distress, Ellen and Lydia are taken with Zeph's more rustic humor, and even in his fantasy world John has trouble winning out.

The Monroes have a new maid who for some reason has a phobia about modern appliances, and Ellen tells John to be kind to her and keep up appearances while she's away. But the maid finds John, who is working in the attic, as distracting as the appliances.

John finally manages to get his revenge on Zeph Leggin by studying old jokes and using them to defeat the local humorist in a battle of wit. So Zeph decides it's time to move away from the Connecticut village, and a guilty John feels compelled to convince him to remain.

When Greeley decides to dedicate an entire issue of The Manhattanite to children's book author George Lindsay Lockhart, John, who despises people who write for children, is outraged--even more when he discovers that Greeley will be staying in his house as they collaborate. John's ire is raised even more when Ellen and Lydia take a liking to Lockhart. But when the two men start working together, John discovers Lockhart isn't quite the saccharine, optimistic soul he had expected.

Frustrated while trying to buy a Christmas present for Lydia, John makes the unfortunate choice of an American flag as her gift. Lydia is not pleased, and when the people in the neighborhood learn of John's inappropriate gift, a group of them show up at the Monroe's accusing him of having his holidays confused.

During a sixteenth anniversary party for the Jensens at the Monroe's house, Phil loses his temper when his wife Ruth interrupts one of his stories, and when he accidentally spills a martini on her, war is declared. After a skirmish in the grocery store, battle lines are drawn and Ruth throws Phil out of their house, which causes the men, including Hamilton Greeley and a fellow writer named J.J. Howard, to gather at a bar and decide how to prevail.

Lydia is supposed to go to a dance with a boy named Elbert, but when a bully beats him up and insists that Lydia go to the dance with him, John takes the side of the underdog and tries to talk Elbert into retaliating.

Lydia is concerned about nightmares, so John tells stories about his family during his childhood in Columbus, Ohio. He recalls several eccentric relatives, including his Aunt Hester, who was so afraid of burglers that she put her household good outside her bedroom door every night so no one would break in to steal them.

When a neighborhood boy tries to tell Lydia about the facts of life, she responds by punching him in the mouth. While Ellen is mostly concerned that Lydia has given the boy a loose tooth, John attempts to discuss the concepts of inferiority and superiority with his daughter

When both Ellen and Lydia's teacher Miss Skidmore agree that John's cartoons are causing his daughter acute embarrassment, John goes to the school and ends up in the office of the principal, who John imagines as a Nazi out of a World War II melodrama.

When Ellen and Lydia go on an overnight trip, leaving John home alone, he finds himself interrupted in his work by a pair of movers and goes into a fantasy concerning him and his beautiful new neighbor.

John suggests The Manhattanite use marriage as the theme of its anniversary issue, and he has his own ideas on the subject. After he elaborates on his thoughts on marriage, including the tendency of wives to tardiness, he ends up being late for a lunch date with Ellen.

When John begins collaborating on a book with a female writer, Ellen suspects he may really be having an affair instead.

John is suffering from cartoonist's block, making him irritable at work and then later at home. In his frustration he chases Lydia out of his study, causing her to fall and accidentally break her arm. Everyone seems to want to take the blame for Lydia's injury, and Ellen thinks she has a solution, at least to John's feelings of guilt.

John once again has to deal with rejection, not only by Greeley, who can't find the humor in one of John's cartoons, but by the young editor of Lydia's sixth-grade school newspaper. John is upset by this double rejection, but his attempts to plead his case don't go the way he wants.

After both Ellen and Greeley accuse John of hating women, John becomes unable to think of any other kinds of cartoons to meet his deadline than ones which back up their accusations.

When Phil gives in to his son's wishes because of feelings of guilt, John chastises him for being weak, but when John himself misses a picnic he'd planned to take with Lydia, he imagines the negative consequences of his forgetfulness by conjuring up three possible Lydias of the future, none of them better off for his neglect.