Andy is surprised when ex-husband Les shows up unexpectedly after Lizzy has her knee operated on after a soccer accident. Les learns that his wife is dating Milo. Andy invites Milo to dinner to meet Les and is shocked by the tragedy that ensues. Andy meanwhile treats a prominent judge for hearing loss and has trouble figuring out the cause of it.

Andy and Milo are invited to stay in a beachside cabin owned by a patient of Andy's in a beachside vacation community. The vacation gets interrupted when a young boy suddenly becomes very ill with similar symptoms to Andy's patient who has cancer. Andy is furthur shocked to learn that 9 other residents of the town have died from cancer.

Dr. Campbell treats a patient for what she believes is alcoholism but she won't admit to her drinking problem. The patient's daughter goes to desperate measure to get her mom to stop drinking. Another of Andy's patients needs to get a kidney transplant but nobody in her family is a match. Tammy's mom then reveals a horrible secret that could save her daughter's life. Meanwhile, Lu, Lana, Peter, and Ben go out on the streets to find out what is threatening the lives of young infants.

Andy tells a famous rock star and a patient to rest and cancel some of her concerts because of fatigue. The rock star invites Lu's young patient who has a terminal disease to spend the day with her. Lu's patient's mother directs a terrible accusation at the rock star. Ben starts a concierge service to keep the clinic open after it faces financial difficulties.

Nick is transferred to Manhatten General. Ben's HIV test has a positive result. Also, Ben hires his ex-wife to make up for the damage he caused to her career. Andy learns that her daughter Jesse's friend is addicted to cough syrup. Kayla Thorton, a new intern, is pushed into the hustle and bustle of the ER. She gets into trouble when she asks a girl if she is sexually active in front of her mother and things go terribly wrong. Jesse gives her friend CPR to save her life after she loses consciousness due to consuming too much syrup. Andy feels responsible for the incident because Jesse's friend was in her care.

Lu treats a patient who may SARS the doctors tell patents about SRS as they wait for the lab tests. Ben comforts a patient. Andy worries that she will lose Jesse if she moves to California.

Ben Sanderson wants to cut screening tests for newborns. A patient of Lu's thinks a patient of Andy's is a fugitive but doesn't believe it. Everyone worries if they will have jobs if Octavian Systems takes over Rittenhouse. Andy is asked to stay on a Rittenhouse, and fights for Dr. Jackson's job.

Lu treats a young girl for E. Coli who may have contracted E. Coli from eating undercooked food. Lu meets Ben Sanderson, a man who works for the company that owns Rittenhouse and wants to film the doctors as they work in order to get more donations for the RWHC. Meanwhile, Andy treats a woman who has been trying to have a baby and learns a shocking secret about her Southern past. Also, Lana gives Lu and Andy's patients advice, leading to amazing results.

A friend of Marc's may be being abused by her boyfriend. Lu treats an HIV-infected woman who looks sicker than she is. An obese couple persues gastric bypass surgery. Dr. Jackson sends Nurse Riggs on an unusual assignment that may turn into another career.

An Indian heiress with a deformity turns to Andy for treatment so that her parents can arrange a marriage for her. Things get complicated when the woman realizes that she will lose the freedoms she has been afforded because of her imperfection. Also, Lu helps an older woman with Alzheimer's use her past for her own benefit. Meanwhile, Andy counsels a young woman who is seeking ""revirginization"" surgery.

Lu deals with the schizophrenic mother who takes her five year old girl who suffers from epilepsy off of her medications in favor of a ""ketogenic diet"" which has stopped all the seizures. Additionally, Andy and Lu have a friendly competition when each one of their patients is studying for a spelling bee. Andy also has to adjust to spending her first Christmas holiday without the kids.

A drug company is offering cash to participants testing a new anti-smoking drug and one of Lu's patients has a very favorable response. An advice columnist Andy is treating loses her ability to read after surgery. One of Bob's daughters needs to be taught swimming for gym class. Lana watches over an elderly senile woman who was left at the clinic with a note. Peter is giving flu shots and a patient has a bad reaction. Andy and Milo Morton have trouble reconciling their busy schedules.

When Andy encounters a young woman with amnesia and her fiance, she must decide which secrets should remain untold. Meanwhile, when a pregnant patient refuses to stop using drugs, Lu faces an ethical dilemma and must decide whether to intervene.

Lu helps a terminally ill patient's family deal with the complicated issues surrounding assisted suicide. Meanwhile, when Andy helps a young couple figure out why they are unable to conceive a child, she stumbles upon a cause that changes their lives forever. As Andy and Milo's relationship becomes serious, he invites her to dinner with his parents. However, Milo's mother, Eve, is less than thrilled with Andy being the new woman in his life.

Andy returns to the Army for reserve duty and helps a woman with post polio syndrome (PPS). Sparks fly for Lu when she is reunited with an old friend whose mother is one of her patients. And when Lana asks if the guy was the ""first"" one Lu answers saying he was the only one.

Lu is raped by Rittenhouse's star surgeon — but he insists that the sex was consensual. Meanwhile, Dana attempts to help a critically injured woman whose car crash may or may not have been an accident.

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On a stormy Halloween night, a 7 year old girl suffers a serious burn while trick or treating and the only person who could possibly save her life by giving her a skin transplant is her twin sister. Lu must decide if it is ethical to ask the young girl to proceed with such a risky and painful procedure. Meanwhile, Lizzy and her friends witness a crime in the hospital morque while Peter and Lana get the hospital into the Halloween spirit.

Lu and Andy treat 3 patients that have similar symptoms but seem to have nothing in common. Meanwhile, Andy must meet face-to-face with the drunk driver who killed Milo. Andy is horrified when Jesse befriends him after he gives a speech about the dangers of drunk driving at her school. Meanwhile, Jonas is investigated for insider trading. Later, in a shocking climax, Jesse is in a drunk driving accident.

Lu treats a young patient with Bi-Polar disease which causes her to act hazardously violent. Her mother must decide whether to keep her or give her up to a mental institution. Meanwhile, Andy helps a woman have an invitro fertilization. She uses new technology to help the couple have a boy because of a genetic female-only disease in the family but later a web of lies and deceivements is revealed. Peter gets jealous when Kayla dates a man he volunteers for at a zoo.

Andy diagnoses a patient with uterine cancer. The patient had gone to nine other doctors and all of them had declared her perfectly healthy as they didn't give her the test needed to diagnose the cancer. She is furious and sues her insurance company. In the end, she does something that will shock you. Meanwhile, an adoptive mother of a 5 year old daughter may be forced to return her to her former-drug addict mother who abandoned her at Rittenhouse 5 years before.

An estranged sister must work up the courage to ask her Olympic gymnast sibling to donate her liver to save her life. Andy and Kayla help a clinically depressed and struggling resident get back on track after a suicide attempt. Lu tries to convince Jonas not to build a large discount multi-purpose store in her neighborhood as it would close down many of the mom and pop stores that had been there for years.

Dr. Campbell is asked to write an endorsement for a new book about female heart health written by a friend and patient. After the author dies of a heart attack, her husband refuses to publically announce her cause of death because he fears it would hurt sales of the book even though her diet had nothing to do with her death (she had heart disease). Lu is shocked when three high school girls come into the ER with similar and shocking symptoms that point towards poisoning.

After Andy saves the life of a gunshot-wound victim, she and Robert must decide whether to accept a donation to the health center from the patient's less-than-reputable father. Meanwhile, Lu helps a breast cancer survivor to overcome her fears about body image and dating after a mastectomy. Also, while planning Jesse's Sweet Sixteen birthday party, Andy must come to grips with the impending financial limitations that her divorce will place on her family. When one of Andy's patients suffers from a heart attack, she and Lu disagree about the cause.

Andy and Lu put their heads together when each of their patients show signs of being poisoned. It appears their exposure to chemicals may turn out to have more to do with where they shop. Lu tries to mediate between an alcoholic and the daughter offering a piece of her liver for transplant.

When a patient of Andy's takes a turn for the worse under Lu's watchful eye, the two doctors butt heads over whether proper procedure was followed. Meanwhile, Andy questions whether or not she can trust her oldest daughter. Also, when Andy and Morton try an experimental xenotransplant (using the heart of a chimpanzee), Peter questions the rights of the animal.

When Lu's (Rosa Blasi) patient receives a desperately needed transplant, Andy (Patricia Richardson) has designs on the discarded liver. Also, when one of Lu's patient's ex-con husband returns home after more than three years in prison, he may be suffering from more than depression. Meanwhile, Andy considers taking her relationship with Dr. Morton (Richard Biggs) to the next level while Lana's (Jenifer Lewis) life is turned upside down when someone from her past returns. Dr. Biancavilla (Brennan Elliott) faces a moral dilemma when a paramedic friend is pricked by an IV drug user's needle.

Dr. Campbell files for divorce from her husband while battling a cough. Lu tries to stop a boxer from fighting her next match. Lu tries to get Andy to look at her but she thinks it's just allergies. Andy treats Blain who doesn't feel good. Lou looks at Lyla who has SIS (Second Impact Syndrome) and wants Lyla to stop boxing because her next match could kill her. Lu heads to the boxing ring to ask Lyla to stop and doesn't listen. Blain learns she has ATL (Adult T-Cell Leukemia.) Lu tries to track down Andy's chest x-ray thinking she may have Lung Cancer. Dr. Campbell learns she has lung infection.

It's Christmas at Rittenhouse Hospital. A woman engaged to be married finds out she's pregnant — even though she's a virgin. Robert fires a kitchen employee, assuming her to be drunk on the job. Lu later diagnoses her with Lou Gehrig's disease. Lu's son Marc develops a crush on a runaway teen.

A journalist comes in with an infection on her foot and Dana(Janine Turner)realizes that she is actually a closet heroine addict. Lu (Rosa Blasi) is called to the emergency room when her patients, a deaf family, are brought in following a fire in their apartment building. She worries about their safety and suggests a risky ear surgery for them — but the husband disapproves. Lu brings her boyfriend home to meet Marc(Chris Marquette).

As Dana & begin to work together, Dana has to tell a surrogate couple that their unborn baby has a defect that will cause it to be mentally disable. After the surrogate couple tells Dana they will put the baby up for adoption. Dana tries to get the biological mother, who can barely afford to take care of her other children, to keep her baby. Lu finds out that a woman who claims to have had a hysterectomy has not.

Lu coaches a teenage basketball team and is troubled when a player faints at a game. She later finds traces of steroids in her blood and wonders if the entire team is on the drugs. Dana is mystified when a complete stranger shows up in the ER with Dana's name and phone number in her purse. Dana must make a difficult decision for the women and regrets that she can't find her family so they can decide.

Dana has big problem on her hands when Susan Jackson comes to the hospital with bruises. Dana wonders if Robert Jackson gave her the bruises because their marriage problems. Dana gets the feeling Susan may not be telling her all she knows. After Dana learns Robert found his wife at the bottom of the stairs Susan tells that had double vision leading Dana to believe Susan might have Multiple Sclerosis.

When a command pilot learns she has a brain disorder she must learn to cope with not being able to fly a plane anymore. Dr. Stowe tells Jane that it would be wise to quit her job as an airline pilot before her disease progresses to where she will be unable to do her job properly. Dana questions whether or not to put her patient's privacy at risk as well as her own career as a doctor by telling the airline that she can't do her job anymore due to her illness.

Dana goes underground to help the wife of a high-powered real estate developer whose financial grip on his spouse is making her black and blue. Meanwhile, Lu comes between an orphaned boy with attention deficit disorder and his foster guardian when she finds the Ritalin she prescribed has fallen into the wrong hands. Lu finds a bit of romance over a Philly cheesesteak.

Dana takes a leave from the clinic to help her mother through a double mastectomy. Lu's impromptu safe-sex speech at a prep school's career day puts her in the middle of a legal dispute over a date rape. Peter's ""alternative"" approach to pain management for a patient with Hodgkin's disease gets them both arrested. And Dana and Lu must each decide how much they want to know when they are both tested for the mutated BRCA1 and BRCA2 genes that would reveal a predisposition to breast cancer.

Dana waits for Nick to decide when they will get married, and treats a figure skater who's determined to compete in the Olympics despite being diagnosed with osteoporosis. Elsewhere, Lu takes an instant dislike to her son's new girlfriend's father (Don Michael Paul). Lana looks forward to graduating from high school. Peter finds his new romantic relationship to be fleeting.

Lana bets her pink feather pen that she'll sign up more people than a friend will for the Rittenhouse Breast Cancer Walk. She faces some difficulties, however, and goes to extreme measures to get people to sign up. Lu tells a teenaged patient that she is pregnant and she in turn tells Lu that Lu's son Marc is the father. In a shocking ending, the girl reveals a horrifying secret. Andy, meanwhile, takes action when Lizzy's friends receive ""fat letters"" and instead makes the school food healthier when Lizzy starts to severely diet.

Andy is considered for the prominent Chief of Surgery position (after the current Chief retires) and discovers a competitor bribing members of the board which is going to decide on a replacement. In the midst of this, she must decide whether or not to perform a potentially career-hurting dangerous surgery on a pregnant woman run over by an SUV driver talking on their cell phone. Meanwhile, Lu battles a company that wants to take her financially-deprived patient's cells to find a cure for leukemia without paying her. Also, Lana finds romance over dog residue.

With Christmas only a few days away, Lana goes on a frenzy decorating the clinic and organizing a Secret Santa gift exchange. However, when a plan to set up Peter and Kayla backfires, she has a lot of explaining to do. Meanwhile, Lu delivers a virgin surrogate mother's baby but when the parents find out something about the baby, they do the unthinkable. Also, Andy must find a young girl who may die if she doesn't get treated for a deadly disease she may have.

Dr. Lu Delgado is running out of money to run her free clinic by herself. When Lu goes to prestigious Rittenhouse Hospital to ask for assistance, famous O.B.G.Y.N./surgeon Dr. Dana Stowe blames Lu for ruining her breast cancer study to find a cure for cancer after Lu tells a woman her opinon about test studies. Dana later is asked by Chief of Staff Dr. Bob Jackson to tour Lu's clinic and see if the clinic should get funded by Rittenhouse . Dana tells one of her patients that she has ovarian cancer and that she will not be able to have any children even though she has the desire to. In the end, Dr. Lydia Emerson comes up with the perfect solution to Lu's problem.

Dana treats an HIV positive patient of Lu's when Lu is out of the clinic and learns that his mother took him off the HIV medication with Lu's permission. She is furious and reports the mother. Although the boy suffers terrible side effects from the medication, Dr. Bob Jackson insists that he be put back on it. Dana falls for her handsome intern.

A mother- and father-to-be clash over whether or not to allow Dana to perform in utero surgery to correct a birth defect on their unborn son. Lu must decide whether or not to get involved when a woman she was treating for schizophrenia is charged with murder.

Lana finds a crafty way to help one of Lu's patients, a construction worker with a brain tumor, raise enough money for a necessary surgery. Andy treats a woman who needs to have surgery to save her life. However, the woman refuses to have the surgery performed until she meets her first grandchild, who is about to be born in Paris. Peter tries to find the father of a patient's child.

Andy must face the questions of people opposed to her becoming Surgeon General while she struggles to get Senate confirmation. Lu's unique way of practicing medicine and their relationship challenge her chances. Kayla and Peter prepare for the next step in their relationship but struggle to find privacy. Lu reads something in a newspaper about Jonas that could change their relationship forever.

Lu tries to find out why a young patient has mysterious bruises on her body. Lu suspects the mother of child abuse while Dylan suspects the girl's nanny. Meanwhile, Dylan helps a patient try to combat her ####### addiction and when she has strange symptoms, he goes undercover to find out why. Kayla moves in with Lana when she has trouble finding an apartment.

After a policewoman uses a stun gun to discipline an 11-year-old boy with behavioral problems, Lu takes a special interest in him and the new technique. Dylan is asked to perform a risky procedure by a multiple sclerosis patient who is willing to risk her life to beat the disease. Kayla finds that a patient has come into contact with the deadly poison ricin and is forced to report it to the U.S. Department of Homeland Security.

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An Alzheimer's patient attempts to maintain custody of her 15-year-old son with Down syndrome, and a domestic diva puts the health of her unborn child at risk.

Dana's former beauty queen patient doesn't think her husband finds her attractive and insists on having extensive plastic surgery. Dana refuses to perform the surgery but when Terri Ann lands in the ER, she begins to doubt her decision. Peter tries to figure out why a transvestal is having side effects of menopause and counsels Marc about one of the stickier issues of adolescence. Lu and Lana try to find an appropriate punishment for two young teenagers who spray graffiti outside the hospital.

Environmental toxins in a low-income housing unit trigger early menopause in one of its 25-year-old residents. A new mother spirals into depression and runs away from home. Dana meets Nick's mother.

When a 12-year-old girl is diagnosed with oral gonorrhea, she tells Lu (Rosa Blasi) that she got it from her teacher. Lana (Jenifer Lewis) takes on a new role at Rittenhouse: that of patient. Two of Dana's patients deliver babies — and both newborns have the same father.

Dana Stowe must help a family consider if they should take Scarlett off of life support because of the disease she has. Scarlett has expressed to her husband that she does want life support, however her mom says her daughter doesn't want life support. Dr. Lu Delgado tries to help a Mom understand that she didn't prescribe medicine to help her daughter speak after not hearing anything from her daughter in two years. Dana tries to comebat her fear of flying and needs to do deliver a baby from 3,000 feet in the air.

Dana cares for a dying patient who has been disguising herself as a man in order to fulfill her calling to the priesthood. Lu prescribes Demerol for a woman suffering from sickle cell anemia, but the woman's local pharmacy will not carry high-priced drugs for fear of robbery.

It's an all-nighter for Lu at Rittenhouse — and there's not a moment's rest. Robert's wife, Susan, is back in the hospital as her MS progresses. A baby is kidnapped — from a pregnant mother's womb. And Lana's blind date ends in the ER.