Three teams of North American truckers take on South America's Andes Mountains, where they're out to prove they have what it takes to haul any load over any road. Veterans and rookie drivers alike will have to battle thick Amazon jungles, landslides, and cliffside routes where any mistake can be fatal. It's only the first trip, but already the roads are forcing even the most seasoned veterans to second-guess their decision to challenge "The Death Road."

Lisa Kelly and G.W. take on the same road that almost sent G.W. over the edge the day before, but now, with Lisa behind the wheel and a heavier load, the same mountain's rigged with demolition dynamite and ready to explode. Hugh gets his old truck back and hauls a load of sheep through the dark Peruvian night, where sharp switchbacks and cliffs come out of nowhere. A rough day for Tino means partner Tim is forced to drive and maneuver on his own, and Tim learns how quickly he can go from "hero" to "zero."

Ice Road Truckers Alex Debogorski, Rick Yemm, and Lisa Kelly make a living driving the deadly ice roads of North America, but they've never seen anything like this. To prove they're the best drivers in the world, the truckers head to India to take on the extreme mountain roads of the Himalayas. As Lisa battles the heat and struggles to make the transition from Alaska, Alex slams into not one, but two vehicles out on the crowded roadways. Rick risks a head-on collision with multiple buses that refuse to give up an inch of road as they fly toward him at top speed.

After surviving their first few days in India, the truckers face the most dangerous journey of their lives. Rick and Lisa go deeper into the Himalayas and up a new stretch of road called The Ledge--a one lane cliff-side path with a rock wall on one side and a sheer thousand-foot drop on the other. On the perilous journey up, Rick is bullied by local drivers, and Lisa panics while being forced to the edge of a cliff. Alabama highway trucker Dave Redmon joins the team and quickly has the most terrifying ride of his career. With one trucker already beaten by these roads, one of these three veterans may be the next to surrender.

After receiving more good news from home, Rick decides to stay. He and Lisa drive higher into the Himalayas than ever before with fragile statues of a Hindu goddess. Rockslides and tight roads force the drivers into dangerous situations, and risk breaking the sacred statue--making the whole trip worthless. Dave tackles the notorious "Ledge" for the first time, all while dealing with an oversized load and oncoming traffic.

After two veteran truckers give up and head home, Hugh Rowland and Lisa Kelly are forced to take on the Death Road without spotters. Lisa moves to the Southern Death Road, where she faces her biggest challenge so far--alone. The rookie team of Tim and Tino have to navigate treacherous cliffs as well as tight fits in town, where navigating around cars and buildings may prove as challenging as dodging landslides, all to get their load to a community in need.

Alabama trucker Dave Redmon stares down the notorious Freefall Freeway in a truck that is in horrible need of repair. Roadside maintenance costs him valuable time and he must face driving the roads with terrifying drop-offs at night or risk being late with his very first load. Lisa heads back up to The Ledge, the narrow stretch of road that caused her to quit the last time she drove it. But this time, a flat tire leaves her teetering on the edge of the abyss. And the crowded roads finally bring Rick to the breaking point. The oncoming traffic sends him into an angry fit on the side of the road and when his greatest rival--the aggressive bus driver--attempts to pass him on a narrow stretch, Rick refuses to back down, even with oncoming traffic bearing down on them both.

On their last runs in Peru, all three trucking teams are charged with delivering loads to a large, local festival, high into the Andes. Lisa and G.W. haul a load of bulls, some of which have G.W. running and diving out the bulls horns' reach. Veteran Hugh Rowland hauls a truck full of fireworks and firework towers, forcing his truck through fire and flames in the process. Tim and Tino also haul bulls, and Tim tests his speed in the ring against the dangerous animals.

The rookie team of Tim and Tino are feeling more confident than ever, and are out to prove they can drive with the veterans by challenging trucker Hugh Rowland to a race down the Death Road. But Hugh isn't ready to hand over his title as "fastest man," and is forced to make up lost time and miles on one of the deadliest roads on the planet. Lisa Kelly settles in with new partner G.W. Boles, doing whatever they can to deliver their load--local crops and the farmers that grew them--to market in time.

All three trucking teams get a little entertainment in on the side when truckers Tim Zickuhr and G.W. Boles show what they've got in a Bolivian Cholita Wrestling ring. Back on the road, it's the team's last chance to prove they have what it takes to conquer the death road before moving on to Peru. Lisa again relegates G.W. to the spotter's role, still hesitant to let him take the wheel. As Tino and Tim climb higher and higher into the mountains, their emergency tank of oxygen comes in handy. Hugh struggles with the altitude and attitude trying to get his truck through tight squeezes and narrow roads. Finally, all the drivers meet up for dinner and recount their weeks on Bolivia's Death Road.

Tensions hit a high point between Lisa her spotter Tashi, forcing Lisa to think about saying goodbye to Tashi and forging ahead alone. Dave's forced to stop in the middle of his run to deal with his overweight load. Rick battles through illness to make his trip on time, giving everything he can into delivering on time.

After conquering the Freefall Freeway, the Cutouts, and the Ledge, all three drivers climb higher, to over 13,000 feet, as they tackle the Rohtang Pass for the first time. Rick delivers a sacred Buddha statue between monasteries. Lisa brings much needed supplies into Keylong--a city normally cut off by snowy winters. Now the snow's melting, and roads are falling apart under rivers and gushing waterfalls.

A snowstorm threatens to cut the drivers' runs short atop the Rohtang pass. Rick's spotter Boyo leaves Rick for a better job, forcing Rick to go it alone. Lisa and Dave drive as fast as they can to beat the storm, but are slowed by mobs of people on the pass. All three drivers get caught driving in darkness and Lisa battles fatigue--struggling to stay awake.

Trucker Lisa Kelly gets a look at her new partner, Texan long-hauler G.W. Boles, and G.W. gets a look at some of the deadliest roads on the planet in his first outing as Lisa's spotter. Hugh Rowland, still trucking solo, does his best not to play demolition derby in a local market with his giant truck. Rookie Tim Zickuhr gets his first shot at the Death Road, and with rookie spotter Tino Rodriguez riding shotgun, the young team struggles to keep their over-sized load from falling off the truck, or worse, pulling them off the cliff.