Karl makes several predictions about humanity's distant future, including his belief that everyone will be ugly, that we will be physically weaker, the little finger will cease to exist, trousers will cease to be produced and we will blend all of our food. Stephen says that if he knew it were the last day of Earth's existence, he would smash up a bar and kill a person. Karl says that he would kick a duck up the arse.

Another question for Karl from "Inside the Actors Studio": "If heaven exists, what would you like to hear God say when you enter the pearly gates?" From Karl's diary: A news report that humans will have spoken to aliens by the year 2025 leads him to worry that aliens will try to read his mind, while a story about a baby who looked like a frog makes Karl think life would be more interesting if there were different types of humans. Plus, Karl's top five freaks.

Ricky talks about undiscovered species. He talks about a drawing he did when he was in his early teens of an animal which consisted of a lion's head, a gorilla's arms, the body of a rhinoceros, the tail of a scorpion and the legs of a cheetah. Karl says that his design for an animal would consist of the head of an owl, an armadillo's body on a slug base and with peacock feathers. Karl talks about having met a man who had drawn a design for a car which enabled defecating while driving. Karl says his father had a friend who kept a monkey as his pet.

After receiving a fan letter asking what body part he could live without, Karl recalls when he tried to wash the dishes without using his thumbs. Other fan mail questions: If Karl could be anyone in the world, who would he be? What does he think of the philosopher Descartes? What does he make of the saying “a stitch in time saves nine”? In “Monkey News,” a builder complains when he discovers a chimp working at a new construction site, only to be told the chimp is a good worker.

Karl discusses his childhood memories of having thousands of Tic Tacs in his house, given to his father by a friend. Karl tells of his visit to a "professional leg rubber", who tells Karl ridiculous things and charges £48 for half an hour. Karl talks about his visit to a Harley Street doctor's surgery for a medical. In the waiting room, he was surprised to find Boyz among the magazines. He looked through it, thinking it might enlighten him about the appeal of homosexual sex.

Adding to his wish list of improbable inventions, Karl offers up a serum that ages dead people backwards. Also up for discussion: Do African families really want goats as charitable gifts? Is a space flight worth the money and effort? If you could have any super power, what would it be? How rare is it to see a Chinese homeless person? In "Monkey News," a Moscow network fired so many employees it had to hire a chimp to host a talk show, with Cher as one of the guests.

More e-mail questions for Karl, such as: If Karl could talk to any animal, which would it be and what would he say? Highlights from Karl's diary, including why he doesn't like meetings, and why he and his girlfriend always get in an argument after she gets a haircut. In "Monkey News": A story from the 1950s about a gangster who bought a racehorse. When none of the jockeys wanted to be involved with him, he got a monkey to race the horse.

Karl ruminates on the insect world; Stephen recalls the horrors of buying condoms.

Ricky, Stephen and Karl discuss capital punishment, the Ten Commandments and hostage negotiation.

Karl shares his thoughts on why insects are so deserving of his attention. Karl talks about his disappointment when learning about a killer octopus; what he would change in crabs; more stuff about insects. Karl's diary is also mostly about insects.

Karl admits he's getting a face rub at a spa, but frets he'll end up getting an enema as well. Also: A discussion about the customs of undocumented tribes in New Guinea. Ricky and Karl's recent trip to an antiquities store, where Karl wondered, "What's the newest thing you've got?" An e-mail from an Australian fan insisting there are dangerous armed dolphins ready to do battle. In "Monkey News," Karl recounts the marital regrets of a sympathetic zookeeper who brings home a lonely monkey

Topics include: school curricula; physical altercations; human anatomy; whistling and happiness; birds and flight; Karl's thoughts on doppelgangers and the Big Bang; and the origins of the universe. Also: a "Monkey News" segment about eye surgery.

Ricky gives Karl some animal facts. Karl ponders the question of whether you control your brain, or your brain controls you. From Karl's diary we investigate the curious case of the invisible Chinese man, why blind people have affairs, the feasibility and usefulness of putting a mirror on the Moon, and birthdays.

Karl explains why he would have liked to join the Army and recounts his most harrowing acts of bravery.

Karl interprets the meaning of wartime sayings and imagines a scenario in which he is the wife of a GI.

Ricky, Stephen and Karl discuss what things Karl would banish from the world, and what item he would take if stranded on an island.

The trio discuss art, including Marcel Duchamp's Fountain and Damien Hirst's The Physical Impossibility of Death in the Mind of Someone Living as well as sculptures. Karl talks about a tricycle-riding fat woman nicknamed Miss Piggy who lived on the same estate as him.Ricky says that adaptations of literature and film can be improved by featuring the Muppets. Karl says that his favourite films are The Elephant Man, Kes and Mission: Impossible 2. Karl talks about his fondness of whistling, and Ricky says that he finds it annoying.

Karl shares his thoughts on medical advancements, how being sick makes him feel better, and his idea for a machine that would allow doctors to feel their patients' pain.

Karl feels he's getting up in age and is starting to spend more time with his doctors. No longer young and free, he thinks about his will, which he believes is a form of charity, though Ricky disagrees. Karl's attorney suggested he marry his girlfriend for tax purposes, which would finally give his parents a reason to meet hers.

A fan letter asks Karl: If he were on a sinking ship, and could only save either Ricky or Stephen, who would he choose? Karl finds a news report that hedgehogs will be extinct by 2025. Also up for discussion: the story of a man who has a transplanted kidney from a woman and now claims he has an increased interest in housework. In "Monkey News": The owner of an airline reportedly hired a monkey to fly as co-pilot during a strike.

Ricky asks Karl if he would give up his real life to live in a virtual reality isolation tank. Karl discusses his thoughts about problems, holidays and happiness. Whilst recounting having met an older man on holiday, Karl finally laughs.

Ricky and Stephen read passages from Karl's diary, which chronicles his daily observations, as well as profound thoughts. A fan letter asks the guys if they had any nicknames growing up; In "Monkey News": When one member of a bobsled team unexpectedly quits at the Winter Olympics, the team secretly replaces him with a monkey.

The trio discuss animals and diseases; evolution; a fly that is supposedly a pet; Karl's diary.

Karl contemplates the beginnings of the Universe, evolution, recycling and toilets abroad.