Edina discovers that both Marshall and Justin have cut off their alimony. After Saffy conspires with Edina's accountant, Edina is led to believe that she is poor, and reluctantly agrees to reduce her expenses. However, during a trip to the supermarket, she and Patsy fill three trolleys with groceries and steal a crate of champagne.

Edina becomes frustrated when she loses a prestigious PR award to rival Claudia Bing, despite having bribed the judges. Worried about her dwindling career, Edina works on a campaign in hopes of upstaging Claudia. Meanwhile, Saffy becomes romantically involved with Gerard, her psychology lecturer, until she discovers that he is married with children.

As Edina and Patsy prepare to attend an underground New Year's Eve rave, they receive an unexpected visit from Patsy's estranged older sister Jackie. Patsy insists on bringing Jackie along, much to Edina's dismay. However, Patsy is disappointed to learn that Jackie is no longer the jet-setting, drug-addled party animal she used to be.

Edina joins a New Age commune, but struggles to fit in and quickly becomes bored. Patsy is disillusioned with her new job in New York due to creative differences with her colleagues. Saffy settles into uni life and Mother spends her days at the house, drinking and ordering from the shopping channel. After realising that their lives are not the same without each other, Edina and Patsy happily reunite on top of Carnegie Hall Tower before returning to London.

Bubble accidentally emails Edina's clients' details to Claudia Bing, who poaches most of Edina's clients, including Twiggy. Patsy—recently diagnosed with osteoporosis—and Edina are horrified when Saffy forces them to attend a Menopausals Anonymous meeting organised by her. In order to save her business, Edina dupes Claudia into buying her TV company—which currently has no programmes—while Claudia also agrees to return several high-profile clients.

Patsy convinces Edina to hire two male prostitutes for an orgy on the night of Saffy's uni presentation. However, Edina is unable to loosen up, and the prostitutes are not particularly enthused, either. Patsy attempts to enliven the mood by playing a video of an orgy from their youth, only to find that it has been inadvertently switched with a tape of Saffy's school project.

Edina builds a panic room. Patsy is at her shop, Jeremy's, when Minnie Driver enters. Patsy, determined to become Minnie's stylist, invites Minnie to Edina's, where she has gathered racks of designer outfits with which to dress Minnie. When Minnie wants a necklace that Edina is wearing, Patsy and Edina fight for it, and accidentally lock themselves in the panic room.

Patsy becomes the subject of a tabloid sex scandal following an affair with a married MP. Edina checks into a hospital for surgery after injuring her big toe. Patsy tags along, planning to undergo a chemical peel in preparation for her interview with Hello! magazine.

Patsy helps Edina break in her new isolation tank upstairs, while Saffy works with classmates on a presentation for her sixth form college's open day. Edina, feeling useless after a newly dedicated and proficient Bubble hauls charge of the office, takes a sudden interest in her daughter's work and begs to be invited to the open day. Saffy vehemently refuses, so Edina spitefully threatens to adopt a Romanian orphan.

Edina has a nightmare about Saffy's baby trying to stab her. It turns out that the face of the nightmare baby belongs to Saffy's midwife, who delights in teasing Edina about these nightmares. Edina expresses her displeasure about this baby. Saffy invites the baby's father to the house to tell him she is pregnant. In the meantime, Edina and Patsy have organised a book club, but no one is interested in reading any books except celebrity magazines.

Patsy is excited to be joining young supermodel Erin O'Connor for a magazine photo shoot in Paris. Edina and a reluctant Saffy come along for a mother–daughter spread. After learning that other models from her generation will also appear in the shoot, Patsy becomes competitive and constantly ignores the photographer's directions, much to his annoyance.

When Saffy hires a handsome landscape gardener to redesign the backyard, Patsy recognises him as Jago Balfour, the younger brother of a wealthy acquaintance of hers, who inherited a country estate before dying of an overdose. Presuming Jago to be rich as well, Patsy goads Edina into seducing him.

Edina begins an ad campaign for Prince Charles' biscuits, and claims that it is 'by royal appointment'. She begins to associate with the wealthy socialite crowd, and buys a weekend at a country house hotel. Meanwhile, Emma and Sarah bring gifts for Saffy's baby shower, and Sarah becomes obsessed with Emma.

Saffy is preparing her home birth kit, as she's due anytime. Meanwhile, Patsy is the hostess of the Style Awards at the Royal Albert Hall. Edina helps Patsy rehearse her speech but is interrupted by Katy, Bo and Marshall.

After awakening with a hangover, vain public relations agent Edina 'Eddie' Monsoon frantically prepares to launch a major fashion show. Meanwhile, her practical teenage daughter, Saffron—whom Edina had promised to quit drinking—constantly reprehends her mother's unhealthy habits. Edina's enabling best friend, Patricia 'Patsy' Stone, arrives to accompany her to work. At the office, Edina's hopelessly dimwitted personal assistant Bubble reports that one of the main models has dropped out.

Edina is none too pleased about her fortieth birthday. As opposed to the glamourous, star-studded surprise party she had hoped for, Edina is disappointed to learn that Saffy has planned a quiet lunch with family and friends—including both of Edina's ex-husbands, Justin and Marshall, and their respective new lovers, Oliver and Bo, as well as Patsy and Mother.

Patsy falls asleep with a lit cigarette, and accidentally burns down the Monsoons' kitchen. She and Edina later plan a night out, but they decide to stick around after learning that Saffy is expecting a date, much to her chagrin. To make matters worse, Mother inadvertently locks the trio in the living room on her way to the chemist's, forcing them into uncomfortable conversations about love, sex and motherhood.

When Saffy berates Edina for being lazy and incompetent, Edina and Patsy decide to impress her by booking her favourite French film star, Jeanne Durand, to perform at the Royal Albert Hall. However, they're dismayed when Jeanne lip-syncs instead of singing live.

Edina enrolls in a boot-camp fitness programme and subjects herself to a strict diet, after being ridiculed for her weight by Katy, Catriona and Fleur. Meanwhile, Patsy briefly experiments with pulling back her signature fringe for the first time in decades, and budding playwright Saffy receives a visit from Taylor, a pretentious old schoolmate with acting aspirations.

Edina's home is a mess, and she has done some more remodelling as usual. The changes include a pool in her bathroom, and a shower that washes and buffs her like a car wash. New client Emma Bunton visits to discuss new jobs. It turns out Saffy was Emma's head girl at school and Emma knows that Saffy would be disturbed by Edina's squalid abode.