Dennis and Rob start the journey to their first destination -- Lake Titicaca in Peru. After a wrong-way bus trip and a ride down the world's highest zip line they experience a gnarly descent down a cliff face with only rebar ladders for support. On the Incan trail, they try new way of transportation: horses, llamas, motorbikes, and water taxis to arrive at the lake, where they race each other in the traditional reed boats of the indigenous people.

Ipanema Beach in Rio de Janeiro is the new destination, and trip includes a farm-harvester ride; and a trip down the side of a 40-story building on a motorized window-washing scaffold. Also: a railroad handcart.

Chinese fighter planes are used to start the journey to Victoria Falls, near Zambia; the savanna is crossed on German bikes; and an abandoned Japanese jalopy is transformed into a safari wagon. Also used are donkeys and canoes.

After the boys leave the beautiful and legendary Victoria Falls they begin a new adventure to their next destination--Lake Tanganyika in Zambia. These two travelers will challenge themselves across Africa to get there. Having fun in a funicular, getting fired up on a steam train and dying to drive a hearse, Dennis and Rob will do anything to finally reach the second largest freshwater lake in the world.