Brilliant and brusque renowned surgeon Martin Best leaves his lucrative career in Boston to become the general practitioner in the small seaside village of Port Wenn, Maine. One local teacher, Louisa Gavin questions his harsh demeanor, while Martin quickly gets annoyed by the antics of its town locals, all while hiding his debilitating aversion to blood.

After Martin comes face to face with his childhood bully and diagnoses a potentially contagious illness, he is forced to cancel Port Wenn's monthly baked bean supper, angering everyone in the town. Also, Louisa observes Mark getting friendly with her teaching assistant, while Elaine steps in to help Martin in an unexpected, but very much needed, way.

On the eve of Port Wenn High School's baseball team's playoff game, the town is furious with Martin when he accidentally breaks the arm of their star player, who happens to be the son of his high school bully. However, Martin suspects the boy has a more serious condition. Meanwhile, Elaine moves into Martin's waiting room after fighting with her mom, Aunt Sarah rivals with a fan of the opposing team, and Louisa makes a conscious effort to make some female friends.

Port Wenn's favorite hunky wilderness survival instructor goes missing after Martin deduces that he desperately needs medical help. Also, the locals are furious with Martin after he calls the health inspector on The Salty Breeze suspecting food poisoning and Elaine decides to skip her mother's wedding to the school principal.

While conducting a wellness check on the agoraphobic recluse who controls the town power grid, Martin's brusque bedside manner ultimately causes a massive town black out; as the townspeople fight for electricity, Martin befriends a young boy who reminds him of himself; Louisa and Mark share a romantic moment in the dark.

On the eve of Port Wenn's annual blueberry festival, Martin treats a local man who has apparently become blue from eating too many blueberries; Martin is disturbed by Aunt Sarah's lack of attention to her health.

When Port Wenn puts on their annual 'Blood Factory,' celebrating the gory horror novel set there, Martin must contain his secret debilitating blood phobia when Louisa gets seriously ill and needs his help. Meanwhile, the town is all atwitter when the novel's author is rumored to be making a surprise visit to the event.

Port Wenn eagerly goes into high alert when a corpse is found in the town's bog and Martin's autopsy reveals that he was murdered. Meanwhile, Martin's solo investigation trek leads him to startling discovery about himself and the new neighborhood watch turns into a gossip-seeking mission.

When Martin's parents make a surprise visit, Martin suspects that his father is experiencing a serious health condition; Louisa is made acting principal; Martin and Robert must operate together on Mark.

After Martin invites Louisa to watch the annual bird migration over Port Wenn, he treats an elderly woman whose hallucinations lead to dire consequences. Meanwhile, Aunt Sarah fumes after the reading of a will leaves her nothing and Martin must perform an emergency procedure on his young friend.

Port Wenn goes on lockdown when a patient with fleas sparks fears of a plague outbreak; Martin must deal with the town gossip when it revolves around him and Louisa; Aunt Sarah feels betrayed by Greg and George; Louisa has an epiphany.

Martin is skeptical when Port Wenn welcomes an extremely friendly delegation from their sister city in Norway and Louisa visits a specialist who just happens to be Martin's ex. Also, Greg believes that he is pooping little men and Mark exhibits troubling symptoms that warrant an intervention.

As the furious people of Port Wenn discover the truth about their deal with their Norwegian sister city, Martin must toggle between the potential revelation of his blood phobia, a startling baby delivery and the arrival of his amorous ex. Also, Louisa receives some thought-provoking medical results and Al and Elaine must navigate their uncertain future.