The manager of a country hotel is found dead. By chance, Don Matteo discovers that the victim blackmailed unsuspecting hotel guests with video recordings. Suspicion falls on a woman who seems to be involved. Her husband accuses himself.

The town's volleyball team won the championship. During the celebration, Varoli, president and trainer of the team, is found dead. Vivana an ex-player of the team is suspected to have committed this crime because she has a motive: Since a car accident caused by Varoli, she is bound to a wheel chair. Don Matteo knows the girl and tries to prove her innocence.

A fire threatens the town. The culprit seems to be a little boy, Fabio, who immediately admits to be guilty. His father is convinced of his innocence and asks Don Matteo for help. It seems that the boy wanted to get his father's attention.

During a religious procession, Benito Lippi is bitten by a snake. Only an antidote can help to save his life, but it is hard to find since the snake is of a rare Asiatic breed. While police investigate who smuggled the snake into the country, suspicion falls on an oriental man who was seen near the victim during the procession.

Tarek, an immigrant, wants to traditionally arrange a wedding for his sons, who disagree with this tradition. To avoid the marriage, Mohammed commits a theft. When his brother Abdul gets involved in a violent crime, Don Matteo begins to investigate.

Don Matteo is on a bus trip when a rich elderly lady is given a fatal shove. Don Matteo watches the scene but is too far away to recognize the guilty. Police investigations lead to the victim's nephew, who sold merchandise on the bus. Don Matteo finds out that the nephew is interested in more than just the inheritance.

A famous chef is killed. Police suspect the Bagnetti brothers, who were evicted by the chef and therefore have a motive. Gerolamo, a homeless man and witness of the homicide accuses Mordelli, another famous chef. Don Matteo thinks that the police in on the wrong track.

Nino Coronna is found in a garden of a villa, next to a corpse. The victim is the owner of the house, Giulia Chimenti's husband. Nino seems to be guilty and is immediately accused of homicide. Maresciallo Cecchini has to investigate alone because Captain Anceschi is a 'special friend' of Giulia. When Anceschi seems to be involved in the homicide, Don Matteo and Cecchini have to uncover the truth.

A police officer who investigates a drug ring - incognito - is obviously discovered and violently punished by the gang. Don Matteo helps investigations.

Another homicide in town: An employee of the research center is found dead. A fellow worker is suspected to have committed the crime, but Don Matteo's investigations point in a different direction.

A film team comes to town. An actor is killed on the set - the gun was loaded with real bullets! The person responsible for the props seems to have a motive...

An inmate is killed in jail. Suspicion falls on a prisoner who claims to be not guilty, although his fingerprints were found on the murder weapon. A scorpion fight, organized by the citizens, points Don Matteo in the right direction.

The father of Laura’s daughter arrives in Gubbio. The young man’s parents demand custody of their grandchild at all costs. Laura and Don Matteo are at odds, but soon after the priest falls victim to deceit and is accused of harassment and even murder.

The stop mother of Assunta Cecchini’s best friend Valeria is found dead. The sergeant’s adolescent daughters idolize their reckless friend who, this time however, has really gotten herself into trouble.

In the series premiere, parish priest Don Matteo investigates a young man's apparent suicide.

The stables of an equestrian center catch fire. Suspicion falls on the old horse groom first, who has a motive to harm his employer. The employer, owner of the stables, might have a motive too - to collect insurance money. With Don Matteo's help and the aid of little boy Simone, the police uncovers the truth.

The young woman Petra (Jacqueline Lustig), on the run from police after supposedly committing a crime, takes Don Matteo hostage. While the police and Don Matteo's 'family' attempt to free him, our protagonist cooks up a plan: In order to escape and to uncover the truth, he tries to become an accomplice to his kidnapper.

The murder of a doctor is investigated.

Don Matteo's help is needed by a young woman, whose family is in financial distress and being blackmailed. The citizens, surprised about their priest's meetings with this beautiful woman, start to spread rumours.

Police officers find Don Matteo, gun in hand, next to a dead body. What happened? During a fight with the killer, the weapon was pushed in the priest's hands while the real murderer escaped. Imprisoned Don Matteo starts to investigate.

A well known entrepreneur is being blackmailed. Suspicion falls on a landlord who had differences with him before. While Don Matteo aids police investigations, the entrepreneur's son is poisoned...

Don Matteo prepares for a funeral when he finds out that the man, who passed away in an old people's home, didn't die a natural death. Suspicion falls on the victim's son's girlfriend, who offers to anonymously pay for the funeral.

A girl dies at a rave party after having taken a drug that was cut badly. While Don Matteo and the Carabinieri are working on the investigation, Cecchini tries to prevent Tommasi and his daughter from spending a romantic weekend together all alone.

After a young woman dies in labor, the woman’s gynecologist is killed. Meanwhile, Tommasi is preparing for a boxing match and is forced to choose a coach - the ready and willing Cecchini or the professional MP Conti…

A falconer who adopted an autistic boy is stabbed to death. Meanwhile, due to a misunderstanding, Cecchini thinks he only has six months to live.

An old celebrity from Gubbio is killed by a dose of insulin. Meanwhile, captain Tommasi must face MP Conti’s father, who has just arrived in Gubbio and thinks Tommasi is his daughter’s boyfriend.