Don Matteo is on a bus trip when a rich elderly lady is given a fatal shove. Don Matteo watches the scene but is too far away to recognize the guilty. Police investigations lead to the victim's nephew, who sold merchandise on the bus. Don Matteo finds out that the nephew is interested in more than just the inheritance.

Police officers find Don Matteo, gun in hand, next to a dead body. What happened? During a fight with the killer, the weapon was pushed in the priest's hands while the real murderer escaped. Imprisoned Don Matteo starts to investigate.

An inmate is killed in jail. Suspicion falls on a prisoner who claims to be not guilty, although his fingerprints were found on the murder weapon. A scorpion fight, organized by the citizens, points Don Matteo in the right direction.

A young boxer dies during training. Accident or homicide? The boy's trainer is accused of the crime. Don Matteo tries to solve the riddle.

Maresciallo Cecchini is suspected to be a drug dealer! He supposedly only keeps his position as police officer to cover up his life of crime. Don Matteo and Captain Anceschi have to prove their friend's innocence.

Nino Coronna is found in a garden of a villa, next to a corpse. The victim is the owner of the house, Giulia Chimenti's husband. Nino seems to be guilty and is immediately accused of homicide. Maresciallo Cecchini has to investigate alone because Captain Anceschi is a 'special friend' of Giulia. When Anceschi seems to be involved in the homicide, Don Matteo and Cecchini have to uncover the truth.

Mr. Morabito has an affair. He buys a rare diamond as a gift for his lover and hides it from his wife - in an inconspicuous container. Mrs. Morabito gives this container - not knowing what really is inside - to Don Matteo, who plans to host a charity event.

Don Matteo prepares for a funeral when he finds out that the man, who passed away in an old people's home, didn't die a natural death. Suspicion falls on the victim's son's girlfriend, who offers to anonymously pay for the funeral.

A famous chef is killed. Police suspect the Bagnetti brothers, who were evicted by the chef and therefore have a motive. Gerolamo, a homeless man and witness of the homicide accuses Mordelli, another famous chef. Don Matteo thinks that the police in on the wrong track.

A well known businessman is kidnapped. Who organized the abduction? Police seem to be on the right track and arrest an employee of the victim. While the son takes over his father’s business, Don Matteo finds out that many of the employees have bad interests…

Tarek, an immigrant, wants to traditionally arrange a wedding for his sons, who disagree with this tradition. To avoid the marriage, Mohammed commits a theft. When his brother Abdul gets involved in a violent crime, Don Matteo begins to investigate.

The young woman Petra (Jacqueline Lustig), on the run from police after supposedly committing a crime, takes Don Matteo hostage. While the police and Don Matteo's 'family' attempt to free him, our protagonist cooks up a plan: In order to escape and to uncover the truth, he tries to become an accomplice to his kidnapper.

A well known entrepreneur is being blackmailed. Suspicion falls on a landlord who had differences with him before. While Don Matteo aids police investigations, the entrepreneur's son is poisoned...

A film team comes to town. An actor is killed on the set - the gun was loaded with real bullets! The person responsible for the props seems to have a motive...

An accident occurs during a bus ride. The driver seems to be responsible, tests reveal that he had alcohol in his system. Rumours start to spread in town about the rivalry of two bus enterprises...

A police officer who investigates a drug ring - incognito - is obviously discovered and violently punished by the gang. Don Matteo helps investigations.