Paul F. Tompkins discusses the Ebola Virus outbreak with Star Schlessinger. Paul then reflects on ISIS with Oliver Pouch on "Suck on That, ISIS." Hot Dog investigates the current uses of payphones on "NYSU Investigates." Joe Lunchpail talks about Iceland's plans to ban pornography. Paul and Hot Dog interview Troy Baker about his voice work. Paul interviews Rhys Darby about Short Poppies. Paul then talks to Oliver Pouch, Blue Crab, Star Schlessinger, and Rhys Darby about the War on Football.

Paul F. Tompkins discusses child obesity with Senator George Galapagos, L.R. Doll, Professor Cornelius Nougat, and Hot Dog.

Paul F. Tompkins discusses the republican party with Marlon, Star Schlessinger, Steeewwww, and Yerd Nerp.

Paul F. Tompkins does a "Trump Watch" to see which hallway Donald Trump will come down. In "Shut Up the Vote," Paul, Armond Mite, and Star Schlessinger talk John Kasich's victory as Marco Rubio's mannequin gets sliced by Cold Steel. Thomas Lennon talks about the upcoming season of The Odd Couple and his scripting for Donald Trump. John Hodgman talks about his slogan if he ran for President and talks about the penis research with Lady Weiner and Bigfoot. Paul, Star Schlessinger, Oliver Pouch, and Hot Dog talk about Donald Trump's possible danger to the GOP and the naturalization of immigrants. On "NYSU! On the Street," Brianna Baker asks the African-Americans in Los Angeles on what they think of Donald Trump. As Paul continues his "Trump Watch" while everybody sleeps, he tells everyone that new episodes will resume on June 9, 2016.

In "Shut Up the Vote," Armond Mite, Yerd Nerp, and Star Schlessinger talk about Super Tuesday's debate. Reza Aslan talks about Of Kings and Prophets and takes part in the game "Trumptionary" with help from The Constitution. Mary Lynn Rajskub wears the Quizzle 8000 where she is matched with her idea candidate with help from Ned Cooper and Bigfoot. In "Speak Frankly," Hot Dog talks with Tony Hale about different things. Paul holds a moment of silence for those who lost the election followed by their mannequins getting sliced by Cold Steel's swords. Paul, Star Schlessinger, Yerd Nerp, and Armond Mite talk about the single girl power, the possible closing of Guantánamo Bay, and the rise of the robots.

Hot Dog, Armond Mite, and Dwayne Johnson use the Random Guest Hosting Diversity Wheel to select the substitute host when Paul F. Tompkins doesn't show up. The Guest Host Wheel lands on Half Mexican as Al Madrigal shows up and watches an instructional guest hosting videos left by Paul. In "Shut Up the Vote," Ned Cooper, Star Schlessinger, and Armond Mite talk about Donald Trump and Hillary Clinton being the technical winners. Kurt Braunohler takes part in the "Letter to Our Future President" segment with Lady Weiner. Hot Dog talks about his visit to the red carpet of the 88th Academy Awards where he interacts with Patricia Heaton, Adam McKay, George Miller, Sacha Baron Cohen, Isla Fisher, Pete Docter, Will Poulter, and Whoopi Goldberg. Axel Caballero tells Al and Yerd Nerp about NALIP (short for National Association of Latino Independent Producers).

Paul F. Tompkins talks about the New Year's Resolutions. Joe Lunchpail talks about old news on "News News." In "Get to the Point," Ned Cooper and Oliver Pouch talk about bringing back long-extinct species like woolly mammoths, dodos, and passenger pigeons where Ned is not given enough time to get to his point. Haardvark raps about the recent legalizations of marijuana in 25 states. Hot Dog tries to find a protest to report about in Los Angeles. Paul talks about the protests with Joe Lunchpail, Oliver Pouch, Haardvark, and Brian Posehn.

Paul F. Tompkins discusses the European Problems with George Rooney. Al Madrigal talks about his upcoming Fusion special "Half Like Me" while showing a clip of their project "Wait, What?!" with Hot Dog and Lady Wiener and later reads a letter from his past self. Chimp with a Limp talks about how his toyline was discontinued and the recent technological projects. Paul, George Rooney, Joe Lunchpail, Bigfoot, and Jonah Ray discusses the ideas about the next President of the United States.

Paul F. Tompkins talks about the measles outbreak with Chimp with a Limp. Rich Sommer talks about the final season of Mad Men and improvises the different recent stories with "Doggiestyles with a Z" (which Hot Dog, Lady Weiner, Hot Link, and an unnamed hot dog are members of). Felicia Day talks about her autobiography as she and Paul follow Twitter suggestions which Bigfoot and Ned Cooper get involved in. Paul, Star Schlessinger, Bigfoot, The Constitution, and Rich Sommer discuss the Death of Privacy.

Paul F. Tompkins discusses the Great Pacific Garbage Patch with Bigfoot who is live at the location. Paul interviews "Weird Al" Yankovic where his hot dog publicist Judy is present and "Weird Al" accidentally hits Doug the Bat with a stick when he tries to ask a question. Paul and Professor Cornelius Nougat talk about Space tourism. Armond Mite talks about the trailers to The Second Best Exotic Marigold Hotel, Paul Blart: Mall Cop 2, and Star Wars: The Force Awakens. Paul discusses the Space Race with Ned Cooper, Star Schlessinger, Oliver Pouch, and Andy Kindler.

Paul F. Tompkins shows the stage mom of the fake baby with him and then discusses Chris Christie being under fire with Oliver Pouch. Paul and Ned Cooper collect money for the Tom Petty Cash Drive. Keegan-Michael Key and Jordan Peele talk about their comedy life with Bigfoot helping Paul give Keegan the prizes for being the 100th guest on the show and partaking in "Opposites: Attack" with Bo Beetle and Star Schlessinger also taking part in it. Paul, Yerd Nerp, Armond Mite, Bo Beetle, and Greg Proops discuss the American Sniper controversy.

Paul F. Tompkins discusses the Yoga Pants Ban with The Constitution. Scott Aukerman talks about Comedy Bang! Bang! where he also reminisces about the 90s and re-enacts moments from the TV show Ski Lodge High with Paul, Steeewwww (who portrayed the character Desert Storm Larry), Lady Weiner, Princess, Mark McGrath, and Dennis Haskins (who doesn't believe that Ski Lodge High is a real show). Hot Dog interviews Dan Harris about his work on TV journalism. Paul, Dr. Mooz, Red Crab, Hot Dog, and Scott Aukerman discuss the anti-vaccination movement.