Jenna Dewan-Tatum chats about Season 2 of her Lifetime drama "Witches of East End."

Meagan Good appears in support of her movie "Think Like a Man Too." Also: Ben Gleib, Fortune Feimster and Ryan Stout are on the panel.

Singer Austin Mahone is interviewed.

Sandra Oh is interviewed.

Alex Pettyfer is on the guest list.

Guest host Ross Mathews

Emma Kenney ("Shameless") is on the guest list. Panelists: Brody Stevens; Jen Kirkman; Kurt Braunohler.

Michael Yo, Sarah Colonna, Ryan Stout.

Guest host Fortune Feimster

Guest host Josh Wolf

Eric Bana is interviewed about his starring role in the thriller "Deliver Us From Evil."

Chelsea celebrates Fashion Week. On the panel: Eliza Skinner; Lovi Love; Ryan Stout.

Melissa McCarthy is interviewed. On the panel: Jeff Wild; Loni Love; Brad Wollack.

Chris Rock is interviewed. On the panel: Brody Stevens; April Richardson; and Jo Koy.

Kevin Hart is interviewed.

Lena Headey is interviewed.

Scott Speedman talks about his role in the comedy "Barefoot."

Mariska Hargitay is interviewed. On the panel: Jo Koy; Janine Brito; Ross Mathews.

John Leguizamo promotes his movie "Ride Along." On the panel: Leah Remini; Mary McCormack; Whitney Cummings.

Amy Adams is interviewed. On the panel: Moshe Kasher; Fortune Feimster; Dov Davidoff.

David Spade ("The Spoils of Babylon") is on the guest list.

Comedian Gabriel Iglesias is on the guest list.

Jason Biggs ("Orange Is the New Black") is interviewed.

Joel McHale is interviewed.

Interviewee: Kelly Osbourne Panelists: Kerry Kenney-Silver, Jamie Lee, Jo Koy

In her opening monologue, host Chelsea Handler talks about what she did today at the studio on this the last day of the show, including the last communal shower she had in the Chelsea Lately shower facility. Chelsea and Chuy bring on her current stable of round table regulars. What Chelsea believes is going to be three of her closest celebrity friends, Mary McCormack - her best friend - Jennifer Aniston, and Sandra Bullock, providing a gracious send-off ends up being what they hope will be more useful for Chelsea's life. Chelsea's ex-lover 50 Cent and G-Unit perform their new single, "Watch Me". Chuy, via a prepared video, talks about what this show and Chelsea have meant to him. Miley Cyrus, in tribute to it being the last show, performs the pop classic, "It's Over". And many of Chelsea's musical friends, and some non-musical friends, help her serenade E!, to who she is grateful for the past seven years.

Model Chrissy Teigen is interviewed. On the panel: Josh Wolf; Loni Love; Gary Valentine.

Sarah Silverman.

Drew Barrymore and Adam Sandler are interviewed.

Don Cheadle is interviewed.

Chelsea chats with Emily Mortimer about the HBO comedy series "Doll & Em."

Kurt Russell chats about starring in "The Art of the Steal." On the panel: Sarah Colonna, Moshe Kasher and Fortune Feimster.

Sharon Osbourne.

Chelsea Handler talks about taking every opportunity to liven up an event, but one event for which she has not been able to do that. Chelsea and her round table panelists Ian Karmel, Jamie Lee and Dov Davidoff discuss Lady Gaga's record sales declining, a movie theater in Florida accidentally showing the adult Nymphomaniac (2013) when it was supposed to show the family-friendly Frozen (2013), the increase in the prescription of Adderall for a variety of issues, and a Kenyan man sentenced to ten years in prison for raping a goat.

Vanessa Hudgens is interviewed. On the panel: John Caparulo; Fortune Feimster; Julian McCullough.

Jane Lynch is interviewed. On the panel: Chris Franjola; April Richardson; Gary Valentine.

Drew Brees is interviewed.

Moshe Kasher, Heather McDonald, Bobby Lee.

"Nurse Jackie" star Edie Falco is on the guest list.

Kelsey Grammer is interviewed.

Johnny Weir and his husband split up, Selfies are causing a rise in plastic surgery, Is Malaysian Flight 370 somewhere off the coast of Australia, and snowboard champion Shaun White is here.

Jamie Foxx is interviewed. Also: John Caparulo, Beth Stelling and Brad Wollack appear on the panel.

Comedian Chelsea Handler talks about celebrity gossip, pop culture and interviews celebrities while giving her audience something to laugh at. She is accompanied by her round table guests which usually future comedians or E correspondents. She also still has her little assistant Chuy by her side.

Guest host T.J. Miller

Comedian Chelsea Handler talks about celebrity gossip, pop culture and interviews celebrities while giving her audience something to laugh at. She is accompanied by her round table guests which usually future comedians or E correspondents. She also still has her little assistant Chuy by her side.

From the No. 1 movie in America The Roommate, Minka Kelly is here. Comedian Joy Koy, actress-comedian Arden Myrin and comedian Greg Proops.

James Blunt is here and he's got a new album called Some Kind of Trouble. Musician Jeff Wild, TV personality Ross Mathews and comedian Gary Valentine

Round table comics include Chris Franjola, Loni Love and T.J. Miller. Tonight's guests are Stella Starsky & Quinn Cox.

Round table comics include Josh Wolf, Kerri Kenney-Silver and Lavell Crawford. Tonight's guest is Reese Witherspoon.

Round table comics include Ross Mathews, Arden Myrin and Josh Wolf. Tonight's guest is Jennifer Aniston.

Round table comics include Lavell Crawford, Tiffany Haddish and Loni Love. Tonight's guest is Gabourey Sidibe.

Round table comics include Bobby Lee, Sarah Colonna and Gary Valentine. Tonight's guest is Tyler Perry.

Round table comics include Dan Maurio, Natasha Leggero and Matt Braunger. Tonight's guest is Ellen Pompeo.

Round table comics include Ben Gleib, Michael Yo and Ross Mathews. Tonight's guest is Dr. Mehmet Oz.

Round table comics include Ali Wong, Fortune Feimster and Heather McDonald. Tonight's guest is Stanley Tucci.

Round table comics include Mo Mandel, Loni Love and Gary Valentine. Tonight's guest is Josh Gad.

Jeff Wild, Arden Myrin, Brad Wollack.

Figure skaters Tara Lipinski and Johnny Weir are interviewed. Also: Dov Davidoff, Whitney Cummings and Tone Bell are on the panel.

Guest host Gabourey Sidibe

Jayma Mays is interviewed.

Mindy Kaling is interviewed.

Rapper 2 Chainz is interviewed. On the panel: Julian McCullough; Brad Wollack; and Liz Carey.

Jenny Slate chats about her movie "Obvious Child." On the panel: Liza Treyger; Jen Kirkman; Julian McCullough.

Bel Falcone is interviewed.

Marlon Wayans is interviewed.

Emmy Rossum talks about Season 3 of "Shameless." Ben Gleib is on the panel, along with April Richardson and Ryan Stout.

Brooklyn Decker is interviewed. On the panel: Michael Yo; Loni Love; and Matt Braunger.

Chelsea Handler talks about Chuy's advice to her about health care. Chelsea and her round table panelists Jeff Wild, Sarah Colonna and Chris Franjola discuss Fortune's latest adventure in Las Vegas, Alec Baldwin's talk show being canceled because he used homosexual slurs in public, the trip to Tokyo that many of Chelsea's staff took last week, Josh Brolin checking himself into rehab, and a lesbian waitress stating that a couple didn't give her a tip since they didn't agree with her lifestyle. And Chelsea chats with guest Mary J. Blige.

Sebastian Stan chats about his role in "Captain America: The Winter Soldier." On the panel: Kerri Kenney-Silver; Dustin Ybarra; and Heather McDonald.

Helen Hunt discusses her role in the film "Decoding Annie Parker."

Jason Priestley chats about his memoir.

Gabourey Sidibe talks about her role on "American Horror Story: Coven." On the panel: Kerri Kenney-Silver; Natasha Leggero; Bobby Lee.

Michelle Monaghan ("True Detective") is on the guest list. Panelists: Natasha Leggero; Sarah Tiana; Whitney Cummings.

Director McG ("3 Days to Kill"). Also: Jeff Wild, Cameron Esposito and Matt Braunger are on the panel.