Dusty Crum and his team of snake hunters devise a plan to stop Florida’s invasive pythons from spreading north and becoming a national emergency.

While Dusty and the team stave off the spreading invasion by creating a “tourniquet” at the Stormwater Treatment Areas, Gary lobbies to go down south and hunt for a new record-breaking snake.

Winter's arrival drives mating pythons underground, forcing the team to navigate a network of dangerous tunnels.

Dropping temperatures force Dusty and the team to change hunting strategies, but a run-in with his old rival Cowboy throws the team off the trail.

To stop pythons from establishing new breeding colonies, the team hunts in the Florida Keys, and Dusty tries to recruit the next generation of snake hunters.

Dusty and team discover a frightening new hybrid Python species when they trek deep into the dense Python Pines to prevent the snakes from laying their eggs.

Dusty and his team mount a hunt from a swamp buggy before racing south to the python-infested Ten Thousand Islands off the coast of southwest Florida.

Dusty leads the team to an abandoned missile factory near the epicenter of the snake epidemic that could hold the biggest concentration of pythons in the Everglades.