Rhonda has bumps all over her head, including a horned growth that has her deeply concerned; Fred has a mysterious condition on his hands and has not been able to get answers from any doctors; Kevin has a huge lump protruding from his hip.

April is covered in bumps that have disfigured her arms; Genner has flown all the way from the Philippines to have Dr. Lee help with his bumpy nose; Chris suffers from psoriasis that nearly covers his body and a bump on his head.

Roger returns with his gigantic nose growths in the hopes that Dr. Lee and her colleagues can help before it's too late. Christine has lost her essence due to a large growth on her shoulder. Tiffany has a recurring cyst on her eyelid.

Gerald is back to see Dr. Lee and a hand specialist about a huge, intrusive bump on his middle finger; Vinnie has a large, embarrassing birthmark on his neck; Leta has a lump on the back of her thigh that she has been hiding from her fiancée.

Taylore is a beautiful young woman who has unsightly elf-like bumps on her ears; Jose never goes out because of the baseball-sized lump on his head; Ken is covered in painful bumps that make it difficult to do everyday things.

Leonard has an alarming bump hanging off of his arm that looks like it's breaking through the skin; Brandon has several lumps on his head that make him fearful for his life; Jess gets a noticeable lump on her butt after falling down the stairs.

Amber has hundreds of tumors on her face; Antonio has a mound on his spine and is afraid it might be impossible to remove; sisters Cheri and Janice both suffer from possibly matching lumps; Tatiana has an embarrassing bump on her butt cheek.

Traci's confidence has been destroyed after years of bullying from the bumps on her face; Ravon has a unique dangling growth on his leg; David has a large lump.

Patrick's nose is covered by huge bumps, and he can barely breathe; Aziza and Lauren are friends who bonded over their matching wrist lumps; Joe has a mound in the middle of his forehead that looks like a third eye.

Tony has large growths on his nose that impair his breathing. Kevin has a bump in his jawline that is a "lady deterrent." Marie has an unsightly lump on her forehead that makes her a hermit. Tommy's leg bump makes it difficult for him to work.

Dr. Sandra Lee treats Heather, who has a huge growth on her leg and fears removing it could leave a keloid scar; Paul has a giant hump on his back.

Ronen's mysterious lump above his knee is one of the largest Dr. Lee has ever seen; Amber suffers from a debilitating skin disease that no one understands; Sandy has a neck lump she calls Tommy; Kristy's eyelid cyst is ruining her life.

Inoke has a huge, possibly life-threatening bulge on his shoulder; Delano returns with his back lump after Dr. Lee removed a liter of fluid from it; Reed has hundreds of bumps on his chest that burst and leave nasty scars.

Gerard is lumpy, he has nearly a hundred lumps varying in size that coat his entire body. Gina has bloody lesions all over and nobody has been able to help her. Eric has a large bump on his head that he calls his "on/off button."

Kelly has a massive shoulder growth. Erica stabbed her hand with a pencil 45 years ago and believes the lead remains trapped in her palm. Paula's painful and swollen feet ooze a substance that emits the foulest of odors.

Belinda's lump on her neck causes her to basically be immobile; Nicole won't get married until she gets her arm pit lump removed; Adela's chest and back are covered in wisdom spots; Nick foolishly removed a lipoma at home and now needs Dr. Lee's help.

Melissa has tried to cover a huge lipoma with a sweatshirt for years; Tyler's fear of cancer has kept him from having his huge head lumps diagnosed; Tahj is covered in painful boils; Amber has ear keloids that have taken control of her life.

Jen has substantial growths on her ears that cause her depression, pain, and vertigo. Juliet is under emotional distress because of the bumps all over her neck and chest. Gerald has a mysterious, kiwi-size lump on his middle finger.

Lisa has a horn growing out of the back of her head and fears that it could be cancer; Victor has a bulbous lump on his chest; Chuck has a Popeye-shaped bump on his arm; Christian and Jonathan are teenage brothers with matching lumps.

Half of Mary's body is a size 18 while the other is an 8; Anthony's cyst is in the area called the Triangle of Death; Shane wants to get a lump off his back; Brandi's anxiety may keep her from getting a lump removed from her chest.

Brent has a tricep bump that could be intertwined in his muscle. Jeb loves the beach but refuses to go because of the massive number of blackheads, pimples, and cysts all over his body. Wanda has a mysterious mark that is caving in her side.

Robert carries the weight of providing for his family and the weight of the huge lump on his head. Christina has big, veiny, liquid-filled balloons next to her eyes. Felipe is a photographer with a dry skin condition so severe he risks losing his career.

J-Fab is the life of the party, but her shoulder bump is seriously cramping her style. Dan is a gentle giant with lumps on his head that add a few inches. Teresa's red face and bumpy nose make her feel like a monster.

Audrey pops the painful bumps that cover her body so she can feel relief. Felicia has a peculiar looking dark growth on her forehead. Krista's excessive sweating is so severe that on any given day she could fill up an entire milk jug with her sweat.

Fit guy Alonso wants to show off his progress in the gym, but his 70 lipomas are holding him back. Porscha is a comic book enthusiast with two symmetrical lumps on her face. Jeffrey has a leaky lump named Larry on the back of his head.

Louis is a veteran who is covered in scaly, dry skin that makes him feel like an alligator; Irais's kids are bullied because of the embarrassing growth on her head; Johnny has been living with a stubborn lump on his back for too long.

Krystal, a witch, looks to clear a curse of a cyst from her face. Keven wants to get a butt lipoma removed to get his tush back into a regular shape. Raquel, Dr. Lee's esthetician BFF, almost suffocates Dr. Lee with love and a facial.

Robert has thousands of unique bumps on his arms that Dr. Lee has never seen. Alexis has a painful cheek cyst that oozes and has a pungent odour. Stuart's cluster of back bumps disgusts his wife, but thrills Dr. Lee.

Steven's bump is so large, his daughter thinks he is growing a monster on his back. Catherine's arm lump has grown so big that it's nearly up to her armpit. Ethan suffers from an irritating rash in an uncomfortable and awkward place on his body.

John lost his sight at a young age and soon after began growing lumps on his body. Lynette has hundreds of pebble-sized bumps all over her arms, chest and belly. Gabe cannot imagine going off to college with the unsightly mole on the back of his head.

Casey's birthmark covers most of her face, head and neck. James has mysterious massive growths on his inner thigh and lower abdomen that are completely puzzling. Jerry had to hang up his rock star vocal cords when a lump grew out the side of his throat.

Bob suffers from mysterious open-wound sores all over his body. Virginia's stress-ball-sized lump is such a pain in her neck that she can't wait to have it removed. Ted suffers from flaking, itchy, stucco-like skin and has had no luck finding a cure.

Elaine calls the growth on her love handle her third breast. Jessica's cyst is close to her eye and could be dangerous for Dr. Lee to remove. Dwayne wants his nose bumps removed, but he may not be able to make it through the pain of the procedure.

Natasha has ambitions of becoming a model, but her massive ear keloids are keeping her off the runway. Eight-year-old Wynter wants her scaly mermaid skin cured. Dr. Lee's bestie Raquel needs help with a new product for a private area.

Elizabeth's head is covered with giant cauliflower-shaped bumps. Jamaal has been growing a strange knob on the left side of his butt since he was just a boy. Donna's cracking, bleeding skin condition has aged her face and kept her from being social.

Cedric has a bump on his eye and a painful lump on his neck that have kept him from working. Katherine's large ear cluster puts her neighborhood watch job at risk. Andrea uses makeup to cover the white spots all over her face and body.

Johnnie's crippling psoriasis keeps him from spending time with his daughter. Aimee has a Mohawk of cysts on her head. Edith's face markings and itchy skin condition turn out to be more than she expected.

Brittany has been called a monster due to her genetic condition that causes head-to-toe bumps. Leonardo has a fist-size growth on his head, but he is terrified of doctors. Tamyra has skin so thick that she shaves the bottom of her feet for relief.

Stephen's large, bulbous nose gets him unwanted attention, and he hopes Dr. Lee can help; Veronica wants to be free of secrets, including the bump on her butt; Marty has a large, 30-year-old growth on his shoulder that he is ready to remove himself.

Stacey's shoulder growth prevents her from being the playful teacher she once was. Matthew worries that his mysterious shin rash may be dangerous. Both need Dr Pimple Popper's help to fix their skin.

Jaclyn has a lump on the back of her head that causes her emotional distress. Shane has a growth between his eyes that could put him in danger at his electrician job. Brittany has seen multiple doctors about the sores on her body with no answers.

Dr. Lee faces off with iguana-wrangler Madison's head growths. Chanel suffers from painful cyst tunnels beneath her armpit skin that leak and smell like the food she eats. The dark purple birthmark on Eddie's nose has made him a recluse.

Lattyse was born with a mysterious growth above her eyebrow that gives her headaches; Robert has a tomato-sized growth on his butt cheek that causes him pain and discomfort; Sharon has an embarrassing, stinky, squirting cyst under her breast.

Debra has a large, brainlike growth on the side of her head that feels like a sponge, has crevices and emits an odor. Dusten is a cowboy looking to remove the painful lump on his knee. Ramiro has a bump on his jaw that has already been removed once.

Roger has a considerable growth on his shoulder that he calls his "second head." Jenna is a bubbly teenager with an even bigger bubble behind her ear. Susan is covered head to toe in bumps that get in the way of her everyday life.

Robert is back to see if Dr. Lee and Dr. Umar can remove his recurring head keloid for good. Justice has small lesions all over her body that get inflamed. Mike has hundreds of lipomas that bring him great discomfort.

Jimmy's flaky, raised alligator skin feels like an itchy hell, and he wants it cured so he can find love. Djuka is a stubborn guy with a stubborn bump. Talina has hundreds of tumors all over her body, causing embarrassment and discomfort.

Tameru is a drag queen, but he has a myriad of cysts that are the real drag. Devon has uneven skin she thinks may be the result of a hysterectomy a decade ago. Amy has large growths all over her head that make her look like a hot mess.

After losing his longtime love, Joe wants the large bumps all over his head removed. The itchy, painful rash on Nisa's ears has spread to her face. Jennifer has dark spots all over her face that nobody is allowed to see.

Eric hopes Dr. Lee is able to remove the giant growth from his behind. Breanna suffers from itchy dry skin she can't help but scratch. Michael makes jokes, but he knows the bump on his head is anything but funny.

Keke is covered in bumps that make her embarrassed to be intimate with her husband. Jim is a widower with two lumps who wants them removed for himself and his late wife. Corey has been labelled a devil worshipper because of his forehead growth.

Jacqueline's massive shoulder growth makes it difficult for her to do her favorite hobby: fire spinning. The mysterious bump on James' cheek loves to bleed. Mikalia has had a bumpy, smelly mass on her head since birth.