Forces from the U.S. and Panama collaborate in an effort to locate a vessel with a major shipment of cocaine. Included: When the Coast Guard spot several fishing vessels that meet the criteria, they hope it will lead to the biggest bust of the season.

The U.S. Coast Guard receive intel from headquarters about a large shipment of drugs moving from Colombia to Panama in small boats called pangas. Because canvassing such a vast area will prove a major challenge, Panama's Navy joins the search effort.

In Panama, police arrest two smugglers who claim local gangs stole their drugs, leading to a hunt for the thieves responsible. Also: U.S. Customs and Border Protection search for narcotics aboard a ferry in Puerto Rico.

Panamanian police get intel on a drug exchange. Units head out to surprise the traffickers, but the mission takes an unexpected turn. In Puerto Rico, U.S. Customs and Border Protection oversee the arrival of a ferry from the Dominican Republic.

Dominican authorities gather enough evidence to apprehend a cartel boss, but his possible getaway jeopardizes the arrest. Also: Volunteer work to save patients from drug addiction continues in Santo Domingo.

A Venezuelan cartel boss is tracked down in the Dominican Republic, after which law enforcement prepares to intercept one of his shipments. Elsewhere, a group of recovering addicts travel to the slums to help others struggling with dependency.

Local authorities in the Dominican Republic team up with U.S. law enforcement to investigate a cartel boss operating on the island.

U.S. Navy Frigate U.S.S. Rentz is followed as its crew investigates a suspicious fishing boat in the Caribbean.

Tips from undercover agents and informants lead to a high-speed chase and a shootout in Panama City. In Cartagena, Colombia, a tip leads the Armada on a wild goose chase before they track down the real smugglers.

A rollover accident interrupts a police search in Puerto Rico. But a new hunt begins when officers learn of trafficking in the Mona Passage.

Panamanian police go on a manhunt for a notorious gang leader trying to smuggle drugs; at the same time, the USS Rentz race to get across the Panama Canal in time to make a bust.

The engineers on the USS Rentz must repair their aging ship in time to catch up with suspected traffickers. Meanwhile, Panamanian troops venture in to the remote jungle to confront a violent paramilitary army from Colombia smuggling drugs.

The USS Rentz chase down suspected smugglers before they escape into Colombia's territorial waters. Meanwhile, the Colombian Navy and an American surveillance plane hunt down suspects off the coast of Cartagena.

Panamanian forces spend days searching a suspicious North Korean cargo ship attempting to cross the Panama Canal. The North Korean crew try to sabotage the inspection, but the Panamanians uncover something shocking.