Phoenix, Ariz., is the wholesale drug capital of America, under the control of one of Mexico's most powerful and ruthless drug organizations -Â- the Sinaloa Cartel. Almost 200 miles north of the Mexican border, the city has become the major stopping off point for the large-scale distribution and transshipment of marijuana, heroin and methamphetamine up from Mexico and out to the rest of the country.

Since the days of Kurt Cobain and grunge music, Seattle has been nicknamed Junkietown. The city's liberal laws and high demand for drugs is attracting gangsters and dealers looking to get rich. From the competitive crack business in Belltown to fashionable Molly users on the electronic dance music scene, National Geographic explores the highs and lows of Seattle's drug business.

Denver - the mile high city - has just legalized recreational use of Marijuana. The city's gang-banger dealers have battled falling profits since medical Marijuana became law, and forced them to push new products. This latest move is last straw.

Music and drugs go hand in hand in Nashville. For musicians who don't make it, drugs are the easiest way to make a living. National Geographic talks to a user and freelance cook who makes methamphetamine at home to cover his costs and get high. Then, learn how the 19th Judicial District Drug Task Force is faced with cleaning up after meth cooks' Â- operations that are both extremely dangerous and prohibitively expensive.

See the underground world of drugs through the eyes of its makers. A former British gangster serves as guide into this illicit underworld, visiting a secret hash-making location nestled in the mountains. Check out growers in Holland who are leading a horticultural revolution in high-grade cannabis. Follow a batch of raw opium from an Afghan poppy field to an Iranian heroin lab. Follow the supply chain of cocaine through the eyes of Colombian peasant farmers producing the drug in a paste.

Cocaine and marijuana drug fueled 24-hour lifestyle for Londoners.

Miami - once America's cocaine capital; but no more. The War on Drugs has hit home. Today dealers and users play cat and mouse with the cops and live in dread of the Feds. And a new look drug scene has gone underground.

Deep in the Amazon, Rob—a former Wall Street broker turned healer—has created a free clinic of sorts, administering the highly potent narcotic ayahuasca to trauma patients.

Portland's progressive attitudes have made it a mecca for America's homeless and they're helping fund the deadliest drug market in the Pacific Northwest. Here, pushers prey on the young, handing them free sample bags of narcotics to turn them into new customers. With thousands of Portland's youths succumbing to heroin's powerful allure, local police have made it their No. 1 priority to disrupt the flow into the city by smashing the local distribution networks.

The sale of drugs accounts for billions of dollars in illegal commerce across the globe, bringing untold wealth to a select few. But these men and women who live lavish lifestyles off the sale of drugs rarely associate themselves with the ugly underbelly where their products hit the streets — with users. These stories show that wherever people use — be it an island paradise or a cold city street — they can get lost in the shuffle. This episode will go deep into the stories of the users.

Houston's drug hub is the 'Bloody Nickel' - the Fifth Ward. Five square miles of 24/7 drug and party action. Gangs work across the ethnic divide to keep the drugs flowing; while cops and Cartels vie with each other for control.

Heroin, cocaine and prescription pills in plentiful supply makes Los Angeles one of the biggest drug distribution hubs in the U.S.

Washington, D.C., was once “Crack City” and the murder capital of the U.S. But an increased police presence following Sept. 11 made drugs scarce. In the neighborhoods of southeast D.C., one drug remained — PCP. And it's causing havoc. NGC goes inside the chaotic world of PCP where users think they're invincible and can be driven to insane acts of depravity. Visit the emergency room unit where doctors treat up to 80 psychotic patients high on PCP each month.

Kingston is in the hands of highly organized and warring drug gangs. They manage drug trafficking and distribution at all levels. With the patronage of politicians, they fight hard to protect their turf in a city where poverty and guns drive the drug trade.

Baltimore, a once prosperous city, lost many of its jobs along with its steel mills. In return, the city developed one of the biggest heroin problems in the country. For many of those that remain amid the poverty and abandoned homes, the “Heroin Hustle” is the way of life. One strip of Pennsylvania Avenue alone is estimated to take in $10 million a year from heroin sales. With the business booming, the heroin market is expanding outward to the suburbs, and the authorities are struggling to cope.

New York City is in the grip of a heroin epidemic, as a new generation of middle-class suburbanite dealers hooked on prescription pills switch to heroin, and venture down the Long Island Expressway Â- dubbed the Heroin Highway into urban Brooklyn and Queens to get their fix.

Cannabis is the most widely used illicit drug on the planet. To many, it's an evil weed, but to some, it's a sacred herb, even a lifesaver. For decades the global supply was controlled by criminals, but now a quasi-legal industry worth billions of dollars is booming. Visit growers who are leading a horticultural revolution, hear from users consuming for medicinal purposes, go inside the "Green Rush" of medical marijuana in cities across the U.S. and the violent marijuana cartels in Mexico.

In Vancouver, a suburban gang war and heavy police presence drives some dealers and their customers to move downtown. But the cops are in hot pursuit.

The southwest border of the U.S. is the main gateway for illegal drugs, and Dallas, Texas, is often the first port of call for the Mexican cartel drug trade. In this episode, witness how the Mexican cartels have tainted Dallas by turning it into their command and control center for the trade of their narcotics. Buyers desperate to get a hold of the cartel's high-quality product flock to Dallas from all over the country, giving local dealers the chance to make big money

San Francisco, Calif. — the epicenter of the 1960s' psychedelic revolution — is notorious for drugs. But in the new millennium, the city, especially the gay community, is struggling to recover from a meth epidemic. The enabler of this situation is the Asian cartel, which has been poisoning San Francisco with high quality meth for almost 25 years — but the Mexican cartels are intent on taking over. Nat Geo goes inside one of the worst drug ghettos in America — the heart of the drug trade.

After being rocked by a corruption scandal and a budget deficit in the range of 58 million dollars, the city's police department's staffing and morale are in bad shape. National Geographic follows an elite team of detectives who are trying to establish some control over the free for all drug market. Using their access to the dealers, users, and gang members at the heart of the problem NGC gives us a inside look at the drug infested city.

Known by users as the ultimate “love drug,” ecstasy’s euphoric high comes with major lows: Ravers have died from it and organized crime gangs will kill for it.

Dominican drug networks tied directly to the Mexican cartel are distributing countless amounts of narcotics in the historic city of Boston, fueling a widespread epidemic that law enforcement and emergency services can hardly contain. The Dominican drug organizations are increasingly using Puerto Rican dealers as their middlemen to flood the city with heroin. The epidemic touches all communities, making Boston one of the leading cities for heroin distribution.

In Columbus, Ohio, the purity of heroin is on the rise. It’s more deadly than ever before and local paramedics are fighting to save the lives of struggling addicts.

As tourists flood New Orleans, so do drug dealers eager to make a profit; in a fierce competition one dealer becomes a target when he sells fake drugs.

Marijuana is widespread amongst the student population in Boston and, with National Weed day on the horizon, dealers and students are gearing up.

Thai police battle an addiction epidemic as popularity of meth pill Yaba spins out of control. Dealers continue to find ways to dodge the authorities and keep profits rolling in.

Its spring break in Florida and the wave of students means the demand for drugs is flooding the streets. In a month-long party, springbreakers’ drug of choice is “molly.” For local dealers, spring break is the busiest time of year.

Enterprising inmates in two jails with tough drug policies, one in Calif. and the other in N.J., still find ways to get drugs inside.

From the DEA and dealers to users and doctors, Grim Reaper explores the deadliest drugs across the globe.

Chicago, Illinois, is the drug hub of the Midwest and one of the most dangerous large cities in the United States. The Fourth of July is one of the bloodiest nights of the year and a time when the demand for drugs booms.

Arresting drug dealers is just the beginning for some in the drug game, as some inmates continue to do business behind bars.

Auto crime is the tip of a sinister global iceberg where a car stolen in LA could end up on the Russian black market or a truck taken in Laredo, Texas could become a heavily armored 'narco tank' used in Mexican Cartel gun battles.

When Pittsburgh police crack down on heroin, they inadvertently open the door for wannabe dealers that see a chance to muscle their way into the market with a killer brand.

Delving into the Los Angeles porn industry, where a reputation for illegal drugs is under more scrutiny than ever after a number of HIV scares are changing the toleration of narcotics on set.

Ecstasy rebranded as pure MDMA is exploding in popularity while new-wave dealers try to distribute a molly alternative.

The side effects of drug use can be disastrous, but the people living in the world of the living dead fight an epic battle.

Thousands of students head to Cancun, Mexico for Spring Break and some have only one thing on there mind: to get wasted.

Some call methamphetamine the "Devil's Drug." Often made in less than an hour from a common cold remedy, this powerful stimulant is sweeping across the U.S. and Asia. Follow a raid on a suspected meth lab, stake out a neighborhood pharmacy where addicts attempt to accumulate cold and flu pills, and meet a neuroscientist urgently searching for a cure for addiction. See the dangers of meth and the unexpected physical damages caused by the drug.

A look at the gangs that supply party goers with illegal drugs during New Year's Eve celebrations in New York City.

Follow the rise in demand for narcotics during Mardi Gras, Spring Break, Independence Day, and New Years Eve, through the eyes of dealers, law enforcement and users

The culture of cocaine is deeply entrenched on Wall Street and some will pay more than its worth for the purest quality available. It’s a buyer’s market and dealers must compete to deliver first and close the sale, while keeping up with the changing Wall Street appetite. A new generation of brokers and traders are turning to a drug that keeps them performing at work. And police are coming down on a drug that they regard as Wall Street’s dirty little secret — which is quickly turning into an epidemic.

The local drug scene casts a dark shadow on the sunny lifestyle of Puerto Rico, a place where addicts roam the streets in search of their next fix. For Dr. Panelli, treating abusers for jungle rot,Â"a ghastly condition that comes with using injected drugs, can be an overwhelming task.

Ketamine—chemically, a compound called ketamine hydrochloride—is a drug that was developed in the 1960s to sedate animals and humans for surgery, though it eventually was replaced by medications that worked faster with less risk. Beginning in the 1990s, initially to the puzzlement of police, burglars began breaking into veterinary clinics and stealing ketamine. They soon learned that recreational drug users had discovered ketamine and were turning it into the new hallucinogenic party drug. In its standard powdered form, ketamine looked like cocaine, and could be snorted in the same way. But it also could be easily modified for injecting, smoking or even mixing into drinks.