A man is accused of killing his boss, having been found standing over the body, Annelies and her investigation team are convinced he is guilty. However, following a presentation by Annelies to his students, Professor T has questions if they have the right man. Flamant finds herself in hot water, sparks fly between Daan and Annelies.

A man is found by a dogwalker in a forest; his face severely torched, it seems he has been strangled to death, curiously he has the year 1991 carved into his chest. Days later a second victim is found also with a number carved into his chest - Does Antwerp have a serial killer? Where is Professor T when you need him?

Much to the dean's dismay, Professor T refuses to appear as the second speaker at the annual conference of criminologists. Following the murder of the headliner, the event descends into disarray. Annelies and John's relationship improves, he has gained her trust: she tells him that she burned her father's living will and that she now regrets it. To her amazement, John has a simple solution.

A university's chief librarian is poisoned, police believe he may have been the wrong target and their fears are confirmed when they discover another victim. Professor T is summoned to help solve to help solve the crime, to the horror of Chief Inspector Rabet who is yet to be convinced by his controversial ways.

While the team is closing in on drug lord Mark Desmedt, John discovers that Chief Inspector Rabet and Serge are both working with the criminal. Professor T asks Annelies to assist him with his research in determining the exact profile of a murderer. He wants to find out whether Flamant will be capable of murder when she finds out that her new boyfriend is not what he appears to be.

There is a hit on prominent businessman Johan Verhulst during an official happening. The shooter fails. A few days later a lot of blood is discovered in his upside down turned living-room, but there is no body. Verhulst has disappeared. Jasper deducts everything is staged by Verhulst himself, but then he is found dead after all.

An undercover agent, who is embedded in the drug scene, is found dead in the trunk of his car. The target of the investigation is drug lord Mark Desmedt, but could this be too obvious a suspect? At the university it is Professor T's birthday, catalyzing his odd behavior and visions. Meanwhile Annelies' career comes to a crossroads and she makes a big decision.

Professor T's classes are proving popular. The material he presents is like a thriller that has the students on the edge of their seats and they start flocking to his class in increasing numbers. Annelies receives confirmation that her father's euthanasia request is legally valid and that she has been named trustee. Struggling with this heartbreaking decision, she turns to John for support.

The chairwoman of the school's inspection team is murdered at home. At first sight, it looks like a robbery gone wrong but Professor T is convinced the school principal is somehow involved. Annelies and Daan confront Rabet over his increasing drink problem but agree not to tell the commissioner. Annelies meanwhile, opens up to Daan about her father's Alzheimer's.

A student at a strict Catholic boarding school is found dead in her room. At first the team assume it is a case of erotic asphyxiation gone wrong, but could there be another explanation? Gijselbrecht and Flamant have an interesting meeting. Annelies' father is laid to rest and her colleagues are there to show their support along the way. Rabet returns.

When a girl is raped on campus in circumstances identical to an unsolved case from 10 years previously, inspector Donckers calls upon her former psychological criminology Professor T to help crack an impossible case. Simultaneously expert and eccentric, his curious methods ruffle a few feathers along the way.

After six months in an institution Professor T is released on one strict condition. Daan returns to the office, but things are not easy and Annelies' guilt puts their relationship under strain. However, the old team are back, and their help is needed; a number of fatalities have been linked to eating poisoned sweets, and the trail leads to the manufacturing company.

A student suffers life-threatening injuries as the result of an arson attack, and quite a few people appear to have motives for the attack. Dr. Gijselbrecht sets Professor T an assignment, however Professor T has other concerns. It has been decided that Professor Van der Weyden will continue to teach Professor T's course, but Van der Weyden has a secret.

A plastic surgeon is killed and the police are looking for a woman he spent the night with. Professor T believes she is innocent but Commissioner Flamant has forbidden her team to contact him for help. Professor T begins his own investigation, with serious consequences. Meanwhile, Annelies, agrees to go on a date with Daan and Professor T's mother becomes increasingly concerned about her son.

A series of attacks have been carried out on SUVs. At the same time, pamphlets are being distributed for an anarchist student group which Professor T was once a member of. Professor T invites Flamant to his home for dinner which does not go as planned. Daan's replacement John joins the team; he is certainly an asset and proves intelligent enough to compete with Annelies.

Jitske, a 17-year-old girl with Down syndrome, claims she knows who murdered her mother, but she doesn't want to say who it is. When Annelies shows insensitivity towards the girl, John decides it's time for her to meet his daughter, Elke. Professor T finds that Flamant is being overly friendly and it is making him nervous, especially when she confides in him about her upcoming divorce.