It’s Halloween at Webster High School and it’s Chyna Parks’ first day in the Mutant Program, where monsters go to school with normal high school students. Chyna is Medusa so she fits right in with her new Mutant Program friends: Olive, a mad scientist, Fletcher, a vampire and Angus, a zombie. However, Lexi and the normal kids are terrified of the mutants, so Gibson pairs everybody off to help prepare for the Halloween dance.

After being asked out by Fletcher over and over, Chyna finally agrees.

Lexi decides to have a sleepover party and not invite the ANTs, so Chyna invites Olive to sleep over at her house.

After Darryl gets Chyna a bag from the evidence locker at the police station and finds a new designer bag inside it, he accuses her of shoplifting and sends a police officer undercover. When Chyna, Fletcher, and Olive find out that "Charlie Brown" is a cop and that he is spying on them, they pretend that they are robbing a house.

Chyna decides to get involed in some clubs and sports and joins Cheerleading. Inspired by their friend Olive and Fletcher start a lunch club.

After noticing that her friends have become oddly respectful of Principal Skidmore, Chyna discovers that she has been manipulating the ANTs with a frozen yogurt machine. Meanwhile, Lexi is disturbed by a recurring nightmare where she has a crush on Cameron.

Olive becomes a history teacher.

Chyna, Fletcher and Olive all participate in the science fair.

Tensions arise when Chyna and Lexi both have crushes on the chess prodigy.

After being denied an entrance to a school dance, Olive tricks Chyna into running for student council, Angus then tells her that to run for A.N.T. rep you need to participate in every school activity and Olive was the runner up. So Chyna tricks Olive into running too. Meanwhile, Fletcher feels ignored from China so then Angus then tells him in order to get a girl to like you you first need to relate with their dad. Fletcher then befriends Chyna's dad to see if he has a possibility with China but Cameron gets jealous. At the end, Cameron beats Chyna and Olive for student council and Chyna's dad starts hanging out with Cameron again

Everyone accompanies Zoltan to the opening of the new flagship Z-Store in NYC. Chyna connects with a street performer named Hudson, who puts on a tough guy persona to impress her. Meanwhile, Fletcher gets the opportunity to move to NY as an artist in residence at a museum.

Chyna accidentally convinces her father, Darryl, to quit his job after he tells her much he hates it. Darryl tries finding other suitable jobs, but it is no use. Chyna does not like seeing him depressed, so after she witnesses him track down the remote control very cleverly, she tells him to work as a private investigator. Plus, Chyna creates a fake crime scene at school to get his business started. Meanwhile, Lexi is horrified when she realizes that she and Paisley have the same amount of friends on Wolf Pack, a popular social network. After finding out that Cameron just signed up to Wolf Pack, they try to compete over whose friend request he should accept first in order to obtain more friends.

Chyna and the ANTs are tasked with creating a special project for Black History Month. As Chyna struggles to write a song for her presentation, she decides to lock herself in a recording booth until she comes up with a great song. After accidentally falling asleep, Chyna takes a dream journey back in time where she becomes famous African American music icons from the past, Ella Fitzgerald, Aretha Franklin, and Janet Jackson. Using her dream as inspiration, Chyna writes a new version of the A.N.T. Farm theme song "Exceptional" with lyrics that pay tribute to the great women who came before her.

Chyna helps Cameron track down the model who he imagined was his girlfriend. Chyna, disguised as a model agent, gets Vanessa to date Cameron. Vanessa wants to go on a picnic in a hot air balloon. Lexi gets a new job at Hippo's new restaurant.

Chyna, Olive, Fletcher, Angus and Lexi audition for an exclusive school.

Chyna and the ANTs face a crisis when defects with the zPhone cause customer issues.

Chyna's grandmother visits. Skidmore retires, and she is the new principal, Chyna is happy at first but later she turns the school into a madhouse, so Chyna, Olive, Fletcher, and Angus try to get Skidmore out of her retirement.

Principal Skidmore gives out awards to every student for having talent except Cameron, so Chyna tries to help him find his talent.

Chyna and Lexi both get picked as finalists for the reality show "America Needs Talent" and they end up having to pretend to be best friends.

Both Chyna and Lexi are determined to take home the $1,000 cash prize at a local carnival's Salute to Friendship contest, and conclude that their best chance at winning is to work together. Meanwhile, Cameron and Fletcher spend the afternoon hunting down a carnival character, a giant dragon, who they think has stolen Fletcher's wallet.

The ANTs go to an Australian ANT convention. Coincedentally, Lexi and Paisley went to Australia for vacation, but were stuck at the ANT convention. At the convention, Chyna sees an Australian Nature prodigy named Neville, who has a show, where his name was Tazmanian Neville. Fletcher wants to prove that he has "manly skills", so he asked an Australian supervisor, who dropped him off in the middle of the Australian Outback. Chyna, Olive, Angus, and Neville go to save him, but then learn that Neville is actually an Acting prodigy, who knows nothing about nature. Olive suggests to throw a boomerang to hunt birds, but it doesn't work. Chyna suggests to crack "rocks" together to make fire, but the "rocks" were actually emu eggs. Later on, the 4 of them hide in an old car, when they discuss how much they miss Fletcher. Just when they thought Fletcher was not ever coming back, they saw him riding on an emu. Chyna starts to tell Fletcher that she'd might actually- Just then, the boomerang came back and hit her on the head. Meanwhile, Lexi and Paisley dress up as nerds and participate in the ANTlympics.

When Dixon breaks up with Olive for another girl, Chyna tries to cheer her up.

Chyna, Fletcher and Olive fear funding cuts will affect the art and music programs. Meanwhile, Lexi takes over morning announcement duties from Cameron.

Chyna, Olive, Fletcher, and Angus want to go to an upcoming concert with older kids, but they know Chyna's mom will never let them go. In order to convince her, they pretend they're going to see a kid's band, which backfires when she decides to tag along. Meanwhile, Cameron tries to get backstage at the concert.

Chyna falls for a new student in the A.N.T. Program from England. He's another artistic genius who goes to school as a robot. But when Chyna tries to ask him out, he asks for advice from Fletcher. Chyna tells Fletcher there's a artistic guy that she is secretly in love with, and if she should ask him out. and Fletcher thinks she is thinking about him. But when he finds out that Chyna and the new kid from England are going out, Fletcher gets help from Angus to sabotage the date. Meanwhile, Darryl challenges Olive and Cameron at the arcade to see who can get the highest score on a game, Donkey King.

Chyna, Olive and Fletcher make toys for kids at an orphanage, but then learn that Principal Skidmore is actually selling the toys for profit. Meanwhile, Lexi and Paisley are hired by a mall gift-wrapping

A teen movie sensation Sequoia Jones who is playing the role of a tween musical prodigy and follows Chyna around to study for her role. But then, Chyna learns Sequoia is trying to steal her life.

Chyna gets the chance to have a recording contract, and she has to make a decision between being famous or losing her friends.

Violet, a sports prodigy with slight anger issues, joins the A.N.T. Program. Violet is not afraid of the older kids, including Lexi, who orders Chyna to keep the girl far away from her. Meanwhile, some of the older students take a drivers-education class.

Olive is shocked to discover that her pet robot, Hegel, is no longer functioning and has suspicious screwdriver scratches on his back. When a screwdriver is found in Chyna's locker, Chyna suspects that she has been framed and vows to find the real culprit. In the end, it is revealed that Chyna accidentally overfed Hegel.