Rodrigo has his back on the wall as the French troops occupy the Eternal city, but thanks to his son Cesare, a fragile peace can be negotiated.

Cesare leads an investigative commission into Juan's death, but cannot find the guilty party and soon fears he himself killed his brother.

Cesare's ultimate judgment is realized while Lucrezia struggles to make sense of her family's history and its future.

Cesare and the King of France organize their wedding, one after another, the day of the Assumption, a date when it rains consistently. Cardinal Orsini, very sick, terrified of what awaits him after his death when he thinks about his relationships with friends and enemies of the pope. Lucrezia plays on the big surge of hope caused by the salvation and the power of forgiveness to ease political tensions.

Lucrezia meets her new family with mixed results, while at home a malaria outbreak has historic consequences for the Borgias.

Cesare is brought to La Mancha and goes on trial before the Inquisition, while Lucrezia must use extreme measures to save her marriage.

To prove himself worthy of the crown of Naples, Juan proposes to convert the Jews in a mass christening, but accidentally reveals a dark secret.

By the intervention of Spain, France is forced to withdraw, but Isabella of Spain demands a purge of the Jews from the Eternal City.

While Rodrigo engages in delicate politics, Leonardo da Vinci offers Cesare a powerful weapon and murder visits the Borgia family.

On the occasion of this celebration, Cardinal Riario Sansoni organizes morality recounting the story of Alexis. Far from these concerns, Cesare continuing negotiations to try to raise an army and get a title and a wife. Conversely, Lanzol asks to leave Rome and intrigues in order to devote himself more confidently to Christ.

While Lucrezia is head of the Vatican, Rodrigo Borgia continued his retreat. He tries to erase his feelings of love for Julia and her desire for her own daughter, now married to Alfonso di Calabria. But even away from all temptations, he struggles to get there. For his part, his daughter, a young woman who became regent seat with wisdom and moderation, qualities that are lacking in Cesare. The latter, still at war in Romagna, hopes to achieve with a little luck to defeat Catarina and all the enemies of the Borgia family ...

Sent by Pope Alexander VI, Cesare and Alessandro are entering in Florence. Unlike Jesus, they are not greeted by hosannas and palm leaves, but by the looks of reproach and disapproving murmurs. Under the control of Savonarola, Florence Florence libertine became austere. Later, Cesare attends Mass on Palm Sunday, celebrated by Savonarola. During the ceremony, Nicolas Machiavelli discusses Cesare hoping to join the clandestine opposition to Savonarola. Ironically, Machiavelli tends to Cesare a sling, made with palm leaves tied in a bow shape.

Though officially their uncle, Cardinal Rodrigo Borgia gathers his three children, but Juan's and Cesare's lack of control threaten his life's work.

When a plot to poison the pope is baffled and the pontiff's original testament restored, Cesare watches his brother rise further in Rodrigo's esteem.

Lucrezia is in a delicate position with the return of Rodrigo Borgia. It reigns supreme and does not hesitate to be cruel to his enemies. Pope became a counselor with him, Lucrezia can neither impose his word, nor to stop the fears of her husband, which occurred with the arrival of Cesare in Rome. The son Borgia is carried by his desire for conquest. Fierce, he is ready for anything ...

A quarrel starts among the cardinals and old reckonings are being settled, while Cesare offers his son as a sacrifice to God, abandoning the newborn.

As peace remains brittle, Rodrigo publicly acknowledges his paternity of Juan, Cesare, Lucrezia and Goffredo to strengthen the family bonds.

Each member of the Trinity, Borgia (Rodrigo, Cesare and Lucrezia) must find his own unit: head, heart and soul. Rodrigo confronts his addiction to drugs, Cesare intrigue at the court of the King of France to win the hand of Carlotta, while Lucrezia must overcome the sad reality of her love life.

The crowds gathered on Saint Peter's Square in Rome, while another big celebration takes place in Spoleto. This episode, largely devoted to the celebration, the narrative ends by Rodrigo Transfiguration to a group of children. The story is accompanied by a warning to adults who listen Rodrigo, including Giulia and Virginio Orsini. Rodrigo, Lucrezia and Cesare are transformed as they endorse their new roles, sometimes an inspiration to others, sometimes manipulative attempt to influence them.

With a new pope crowned and order breaking down, Cesare finds himself with more and stronger enemies than ever.

The wedding of Lucrezia to Giovanni Sforza is to seal the union between the Borgia and Sforza families, but the marriage will not be consummated.

Cesare covets the hand of Carlotta d'Aragona and the Naples throne. Rodrigo et Lucrezia, for their part, wold like to turn the page on the death of Juan Borgia.