Cesare leads an investigative commission into Juan's death, but cannot find the guilty party and soon fears he himself killed his brother.

Rodrigo has his back on the wall as the French troops occupy the Eternal city, but thanks to his son Cesare, a fragile peace can be negotiated.

Cesare's ultimate judgment is realized while Lucrezia struggles to make sense of her family's history and its future.

To prove himself worthy of the crown of Naples, Juan proposes to convert the Jews in a mass christening, but accidentally reveals a dark secret.

Cesare and the King of France organize their wedding, one after another, the day of the Assumption, a date when it rains consistently. Cardinal Orsini, very sick, terrified of what awaits him after his death when he thinks about his relationships with friends and enemies of the pope. Lucrezia plays on the big surge of hope caused by the salvation and the power of forgiveness to ease political tensions.

Lucrezia meets her new family with mixed results, while at home a malaria outbreak has historic consequences for the Borgias.

Instead of keeping the peace, Rodrigo gives in to Giulia's urging and has his men take up arms, but under Juan's command the campaign fails.

Rodrigo promises estates and offices for those voting in his favour, and when white smoke rises, he leaves the conclave as Pope Alexander VI.

Cesare is brought to La Mancha and goes on trial before the Inquisition, while Lucrezia must use extreme measures to save her marriage.

In the vineyards of the Palazzo dei Santi Apostoli, Cardinal Giuliano della Rovere selects grapes for the blessing of first fruits. He is assisted by Cardinal Raffaele Riario Sansoni, more concerned with political cases. Released from his vows of Cardinal Cesare is of golden armor that belonged to his late brother Juan. Thus dressed, he poses as a king on the papal throne, having finally materialized all its own idea of "ascension" to heaven.

On the occasion of this celebration, Cardinal Riario Sansoni organizes morality recounting the story of Alexis. Far from these concerns, Cesare continuing negotiations to try to raise an army and get a title and a wife. Conversely, Lanzol asks to leave Rome and intrigues in order to devote himself more confidently to Christ.

Though officially their uncle, Cardinal Rodrigo Borgia gathers his three children, but Juan's and Cesare's lack of control threaten his life's work.

When a plot to poison the pope is baffled and the pontiff's original testament restored, Cesare watches his brother rise further in Rodrigo's esteem.

Lucrezia is in a delicate position with the return of Rodrigo Borgia. It reigns supreme and does not hesitate to be cruel to his enemies. Pope became a counselor with him, Lucrezia can neither impose his word, nor to stop the fears of her husband, which occurred with the arrival of Cesare in Rome. The son Borgia is carried by his desire for conquest. Fierce, he is ready for anything ...

The crowds gathered on Saint Peter's Square in Rome, while another big celebration takes place in Spoleto. This episode, largely devoted to the celebration, the narrative ends by Rodrigo Transfiguration to a group of children. The story is accompanied by a warning to adults who listen Rodrigo, including Giulia and Virginio Orsini. Rodrigo, Lucrezia and Cesare are transformed as they endorse their new roles, sometimes an inspiration to others, sometimes manipulative attempt to influence them.

Cesare's new mistress could trigger a diplomatic incident, and public allegations of debauchery are made against the Borgia family.

Sent by Pope Alexander VI, Cesare and Alessandro are entering in Florence. Unlike Jesus, they are not greeted by hosannas and palm leaves, but by the looks of reproach and disapproving murmurs. Under the control of Savonarola, Florence Florence libertine became austere. Later, Cesare attends Mass on Palm Sunday, celebrated by Savonarola. During the ceremony, Nicolas Machiavelli discusses Cesare hoping to join the clandestine opposition to Savonarola. Ironically, Machiavelli tends to Cesare a sling, made with palm leaves tied in a bow shape.

Cesare stands trial for treason against the Holy See and the Ten Commandments, with his old friend Niccolo Machiavelli as prosecutor.

With a new pope crowned and order breaking down, Cesare finds himself with more and stronger enemies than ever.

The wedding of Lucrezia to Giovanni Sforza is to seal the union between the Borgia and Sforza families, but the marriage will not be consummated.

Rodrigo's death sets chaos in motion on many fronts and forces Cesare to practice his most sophisticated politics yet as stakes are raised.

Each member of the Trinity, Borgia (Rodrigo, Cesare and Lucrezia) must find his own unit: head, heart and soul. Rodrigo confronts his addiction to drugs, Cesare intrigue at the court of the King of France to win the hand of Carlotta, while Lucrezia must overcome the sad reality of her love life.