Rebecca reveals a secret to Sean that reconnects them. Dr. Todd tells Paul and Cathy that the bee therapy did not work. Cathy reconsiders her options. Adam finally shows his softer side in an unexpected way.

Cathy is inspired by Lee’s passing to ring in the New Year in an unexpected way; burdened by financial issues, Paul tries a new tactic with the insurance agency; Adam makes a surprising connection with Dr. Todd.

As Cathy prepares for her trip to Italy, she receives an amicable call from Lee. Elsewhere, Paul uncovers a secret about Myk while Adam discovers one about Poppy.

Dr. Sherman pays a visit to Cathy, who has checked herself into a hospice and is experiencing problems with her new roommate. Adam confronts Paul about his lack of parental guidance. Andrea seeks inspiration from Cathy.

Dr. Todd and Cathy go to see the Bee Man to seek non-traditional treatment for her cancer. Paul is overly supportive of Cathy around the house. Sean gives Adam relationship advice about Mia.

Adam surprises everyone when he fulfils one of Cathy's wishes. Cathy's estranged Dad visits her. Andrea gets the opportunity of a lifetime. Sean has mixed feelings about his impending kidney surgery.

Cathy invites friends and family to a Thanksgiving dinner, but a long-hidden secret she brings to light causes trouble.

Paul seeks support from people at his work place, but gets more than he bargained for. Sean pulls away from Rebecca when it appears she’s getting too serious. Cathy, Marlene and Rebecca have a girl’s lunch at a strip joint -- which unexpectedly influences Cathy’s thoughts about her cancer. Adam meets a girl, Mia, at the bus stop.

Adam's shocking indiscretion threatens Cathy's new job as a swim coach; sparks fly between Andrea and Myk, a Ukrainian coworker that Paul is mentoring; Sean seeks advice on taking the "next step" with Rebecca.

Cathy, eager to try on a carefree, impulsive persona, drains her 401K, buys a convertible and imagines what life would be like if she were Dr. Todd's girlfriend. At his therapist's urging, Paul reignites his passion for rugby. Sean goes to great lengths to knock out a tooth without the help of a dentist. Meanwhile, Adam gets caught stealing and is surprised when Marlene comes to his rescue, until he finds out there are strings attached.

Sean feels inspired to donate to charity. Cathy upsets Paul when she signs him up to an online dating service. Andrea struggles to impress her tutor, Isaac Mizrahi.

Rebecca deals with the grief over her miscarriage in an unexpected way which leads Cathy to reconnect with old friends; Andrea's relationship with Myk heats up; Adam is taken by surprise when he finally meets the girl he's been chatting with in an online cancer support group.

Cathy goes to great lengths to impress the parents of the baby she hopes to adopt; Joy encourages Paul to share his near-death experience with a live audience, while Jessie encourages Adam to deepen his relationship with God.

Cathy finds herself spending time with a stranger; Paul is flattered by the attentions of an American tourist; Sean is guilt-ridden when his sister doesn't return to the dive boat.

Cathy and Paul receive an extraordinary offer from Joy's friend.

Cathy and Paul experience frustrations in bed and with the help of their new house mate Andrea, realize they need to set some patient-caregiver limits; Rebecca is put off by the newly medicated Sean; unsatisfied by his physical relationship with Mia, Adam turns to another girl, Emily.

Cathy focuses on her new personal pursuit while Adam and Andrea each cope with her new direction in their own ways; Sean meets Willy (guest star Victor Garber), the former owner of his sex line business.

Cathy visits a joyologist while Sean and Andrea go out for Valentine's Day.

Cathy tries scuba diving in an effort to maximize the fun on her Puerto Rico vacation; Paul, reeling from the news about Joy, tries to keep it together during a speaking engagement. Later, Sean decides to take a respite from dating after undergoing yet another breakup.

After an argument with Lee and a revealing dinner with Dr. Sherman, Cathy (Laura Linney) comes to a major crossroads. Elsewhere, Adam searches for his AWOL uncle and an impulsive Andrea makes a decision about Myk.

Sean discovers a new and unusual way to generate income; Andrea tries to start an African-American interest club; Adam becomes increasingly devoted to his faith and joins a Bible study group at school.

Cathy is intrigued by Lee, a fellow cancer patient she meets on the first day of her clinical trial; Adam's downward spiral continues with a fight at school and refusal to take responsibility for his actions with Emily; Sean is worried that his new house is haunted.

Due to Paul's layoff, Cathy starts to pawn her jewelry and meets Lee there as well. Adam gets into a situation that he may need help with to get out of. Sean is kicked out of a mother's group when he tests out his homemade sling at the park

Dr. Todd tells Cathy that she’s been rejected from the clinical trial. Sean sets up Marlene on a date. At a party, Adam gets into a fight with Andrea. Cathy and Lenny take ecstasy together. Paul catches Cathy and Lenny having sex. Paul gets too drunk at the dinner to celebrate his promotion, forcing Adam to drive home. Paul tells Cathy he wants a divorce.