A crisis arises when Ryan ignores Wilfred's advice.

In the second-season finale, existential questions are posed to Wilfred and Ryan.

Ryan fears a future without Wilfred, as his battle with cancer becomes more severe. Drew returns from Wisconsin.

Season 3 ends with Jenna forbidding Ryan from seeing Wilfred when he needs him most.

Ryan is put in danger as Wilfred pursues the path to valor.

Wilfred crashes Christmas and pits Ryan against his family.

Ryan's resentment of his mother even grows when she moves in and becomes friends with Wilfred.

Ryan finally learns his truths about Wilfred and his life.

Ryan learns that life is much more challenging without Wilfred around.

Wilfred convinces Ryan to withhold sensitive information from Jenna.

Just as Ryan finds happiness in his life, Wilfred begs him to sacrifice it for a larger purpose.

Ryan befriends Wilfred’s enemy—the mailman.

Wilfred muddles Ryan's plan to introduce Amanda to Jenna.

Ryan tries progressive psychotherapy to better understand a past trauma.

Ryan attempts to discover the truth about Wilfred through self-examination.

Ryan tries to reconcile with his sister, and Wilfred is in for a shock at doggy day care as a result.

A spontaneous road trip proves disastrous for Wilfred and Ryan.

Ryan helps his mother adjust to her new life as Wilfred deals with a new nemesis.

Ryan and Wilfred have drastically different accounts of the same disturbing incident.

Ryan must swallow his pride when Wilfred pursues a new love interest., and Ryan meets a new romantic interest himself

While trying to uncover who his father was paying off, Ryan runs into Bruce, only to be a pawn in his next game.

Wilfred is angry after Ryan tricks him into going to the veterinarian.

Ryan and Wilfred take sides in Kristen's custody battle.

A hairy situation puts Wilfred and Ryan's friendship in jeopardy.

Ryan gets his wallet back (that's the good news) when his malevolent, porn-addicted neighbor Spencer shows up. The bad news? Spencer's looking for answers about who broke into his house. He's also looking for blood.

Disaster strikes when Ryan and Wilfred get an unwanted guest on their camping trip.

Wilfred pursues a forbidden love.

Ryan forms a unique connection with his neighbor's dog after a failed suicide attempt.

Ryan finds a roommate with Wilfred's help.

Ryan has a guilt complex over the death of his childhood dog, and Wilfred, upon learning of it, goes to otherworldly lengths to help Ryan discover the truth about how the pooch passed on. Meanwhile, Kristen throws a party for her boss.