Amy and Richard reconnect while treating a patient whose diagnosis is not at all what it seems. A real life romcom comes to Westside Hospital, bringing love to the forefront of everyone's mind.

Sonya wrestles with treating a guy from her past and must rely on Amy to help her. Richard deals with a family situation. Jake and TJ debate the moral implications of a diagnosis.

Amy must confront who she has become after the tragedy that struck her family seven years ago. Sonya and TJ disagree on how to treat a sick Marine, and Amy and Jake make a life-changing discovery about an Alzheimer’s patient.

Amy, allowed to return to work under strict guidelines, teams up with TJ to treat a patient suffering from mysterious liver problems. Sonya and Jake help an elderly couple navigate the final chapter of their love story.

An outdated medical proxy form creates tension between a patient's ex-husband and current partner. Amy, Jake, and new intern Hannah investigate a college student's sudden blindness.

Amy, finally allowed to practice medicine again without supervision, struggles to diagnose her most complicated patient yet: TJ’s Dad. Sonya and Jake treat a single mom who’s reluctant to stay in the hospital. Richard tires to contain the truth about Dixon.

When Chief of Internal Medicine Dr. Amy Larsen suffers a catastrophic brain injury, her life is turned upside down. Still determined to once again practice medicine, she charts a new path forward, ready to face whatever obstacles stand in her way.

Amy struggles with memories during treatment of an expectant mother's puzzling illness. Her mentor Dr. Joan Ridley makes a visit to Westside.

A patient forces Amy to confront the realities of medical tourism, TJ helps a veteran with his prosthetic and Joan drops a bombshell.

A popular weight loss medication reveals the cracks in a couple's relationship and two sisters face an unexpected diagnosis.

Amy treats a Chaplain who helps her reconcile with the past, while Michael is under investigation for his actions during the hostage crisis.

Amy and Gina, with an assist from Jake, team up to help a victim of domestic abuse, while TJ finds himself in the spotlight when he, Sonya and Liz treat a social media influencer.