Todd Kendhammer claims his wife was killed in a freak car accident but the forensic evidence doesn't back him up.

When Leslie Neulander's death is declared accidental, forensic investigators sound the alarm that it was no accident.

A suitcase filled with unidentified human remains unlocks a missing person's case that has gone unsolved for years; the forensic analysis of a nearly-destroyed cellphone found in the suitcase reveals a mysterious selfie.

When Lanell Barsock is found murdered, it seems obvious to all that her boyfriend did it; when the forensic evidence comes in, investigators are astonished to learn they've arrested the wrong person.

Investigators are convinced that the apparent murder-suicide of Nichole Payne and Taylor Wages was staged. The instincts of the cops, coupled with an outside forensic expert's opinion, convince authorities who the real killer is.

Police finds the body of Misty April Morse floating in a river. With only a piece of nautical rope, a strip of duct tape and some plastic bags to go on, they use every forensic tool they have to catch her killer.