Cameras follow the team every sweaty step of the way as they explore the beautiful wilderness of Guyana, from abseiling down one of the most powerful waterfalls in the world to climbing to the very top of the rainforest trees. Known as the land of giants, Guyana is home to the huge anaconda, the world's largest tarantula and giant otters Gordon Buchanan goes in search of the elusive jaguar, while Steve Backshall abseils down one of the most powerful waterfalls in the world to see the creatures living there. Meanwhile, Justine Evans climbs to the top of the rainforest trees in search of monkeys and macaws and George McGavin explores rotten logs for whip spiders.

The team push further into the jungle wilderness, searching for unusual and endangered animals that live there. Base camp is invaded by scorpions and poisonous centipedes, and Gordon Buchanan discovers an animal thief helping itself to base camp supplies. Steve Backshall finds giant piranha and the long-fanged sabretoothed fish in his river survey, whilst George McGavin catches the world's largest tarantula. The climbing team begin their attempt to scale a huge unclimbed mountain at the forest's edge.

Steve Backshall and the climbing team struggle to reach the summit of a huge unclimbed tabletop mountain on the edge of the forest. The team live rough on the summit, searching for new species and scientific discoveries. Justine Evans searches for giant anteater, while George and Gordon struggle up a remote jungle river to find a rainforest paradise where the animals appear to show no fear of man.