Huff's sanity is seriously called into question by his family after a series of unfortunate and wildly unpredictable events and circumstances, one involving Melody, threaten to make a big tear in the fabric of the Huffstodt family. Russell has to decide if he wants to be a father or not. Izzy refuses to allow Teddy to take a new anti-psychotic drug, one that could also possibly kill him. Beth learns her mother's cancer has spread to the spine. Byrd is a little stunned by the adults pinballing around him. Huff screams at Russell that he's in for a fall.

Huff begins his search for Teddy in Mexico, but cannot find him. He ends up being forced to ask Russell, whom he nearly killed and who wants to have nothing to do with him, for help in locating his brother before something drastic happens. Meanwhile, Beth finds that Madeline has taken a turn for the worse and does not know what to do.

Huff decides to help out Russell once again. Izzy finally decides to visit Teddy. Beth chooses to tell Alec that she thinks of him only as a friend. Byrd gets upset by all his family's latest actions.

Huff's father decides that he will extend his stay, and some family members feel he is wearing out his welcome. Lena asks Huff to address her alternative psychiatric therapy students. Byrd offends some people with his latest art project. Meanwhile, Russell ends up going on a drug-fueled bender.

Huff gets an unexpected visit from his father. Teddy ends up meeting a very attractive young lady while down at the beach. Izzy finds herself arrested on a DUI charge. Beth decides that she will host a meeting of Paula's prayer group. Russell tracks down his young client, who is at a drug house, and then ends up joining in the festivities.

Huff discovers that Teddy is becoming more independent after a conversation he has with Dr. Lena Markova. Beth has a problem with a client at her job and Russell gets an ultimatum from his boss that does not set well with him.

Huff has become ill, both emotionally and physically, because of his relationship with Beth. Some of the things Teddy has told others about his relationship with Alyssa finally catches up with him. Russell fails to a keep an important promise that he made to Kelly. Meanwhile Ben's attempt to reach out to Izzy fails.

Huff's romantic weekend alone with Beth ends up getting very steamy. Izzy meets a man while at a Palm Springs casino. Byrd ends up breaking into a neighbor's house and is caught.

Dr. Craig ""Huff"" Huffstodt is a Los Angeles psychiatrist whose life and career is sent reeling when a tragedy occurs in his office. Huff's nurturing nature is also tested at home as he endures and deals with the conflicting personalities and small insanities within his own family.

Huff is the recipient of two unlikely visits, as his estranged father attempts to use him as a go-between to settle his affairs with his mother Izzy and Doris, a patient's mother, shows up in his office seeking answers she thinks only Huff can provide. Russell is pinned in his own corner when he is enlisted to track down his high-powered TV star client and convince him to sober up and get back to work.

Huff still feels guilty and angry, and so do his family and friends, about his potentially fatal fight with his best friend, Russell. He Beth's mother is dying and Beth is having a difficult time dealing with it. Izzy and Byrd have become estranged from the family. Meanwhile, Russell takes on a troubled new client, Dauri Rathbun.

Huff is forced to defend himself and his practice in front of a Medical Board hearing, with his reckless best friend and attorney Russell by his side. As if this weren't enough, Huff is besieged by Melody Coatar, a dangerously belligerent bipolar patient and is informed that he's being sued by a patient's parents.

Control is an issue in Huff's life, professionally and personally. He goes to Russell's office who pulls no punches when hitting Huff with tough questions in preparation for the insurance hearing to help save his job. At home, Beth gets into a tangle with her mother-in-law Izzy about preserving family privacy early in the morning and Byrd heads off to help tutor Gail, a cute high-school senior. Meanwhile, day two of the hearing begins with a body blow as Huff's bipolar patient takes the witness stand.

With the pressure of the parents' lawsuit building, it's almost a relief for Huff to deal with a normal family crisis. But when his 14-year-old son Byrd sneaks off for a disturbing teenage party and is found out, Huff has trouble convincing his wife Beth that there's anything normal about it.

As Beth prepares for the arrival of her gravely ill mother, the rift between she and Huff escalates, putting them both in a position we've never seen them in before. With Huff realizing that there's no way he'll ever be able to ""put the toothpaste back into the tube,"" Russell confronts the horrifying possibility that he may have unintentionally started a family during a recent ecstasy binge.

Huff is awakened from a disturbingly surreal dream about his estranged father and Byrd. Throughout the dream, Huff hallucinates back to his childhood, seeing his young self, his brother Teddy, father Ben and mother Izzy. This leads Huff into a much-dreaded camping trip with his father and son. Three generations of Huffstodt men together for the first time in the family cabin in the woods. Russell embarks on a liver detoxification and cleansing program, which in typical Russell-style, ends somehow with a client being blown up in a trailer.