In the Royal Palace, Yong Zheng, Emperor of the Qing Dynasty, circulates among his concubines. But trouble arises when one of the emperor's beloved women, the powerful Hua Fei, begins her battle against the new rising star, Zhen Huan.

The Palace of the Concubines showcases endless scenes of betrayal of sisterhood as the women hope to gain power and recognition from the Emperor. In order to rise to the top, they use a variety of deceitful tactics - including faking pregnancy - to survive till the end.

Hua Fei tries to take down Zhen Huan once and for all; however, a twist of fate causes her to lose her title and, at the same time, provides an opportunity for the Queen to remove Zhen Huan from the Palace.

Although banned from the Palace, Zhen Huan finds her own romance with the brother of the Emperor. But when she becomes pregnant with their love child, Zhen Huan must devise a plan to ensure her unborn child's place in the Emperor's dynasty.

Once a sisterly friend to Zhen Huan, An Ling Rong uses all methods possible to get rid of Zhen Huan for good; however, her dirty business ends in tragedy and a potential plot to kill the Queen.

Zhen Huan attempts to frame the Queen and reveal her dark secrets. When Zhen Huan's hatred towards the Emperor is finally released, she sees an opportunity to ascend as the Supreme Empress.