Jess's brother-in-law, an Army deserter, shows up looking for help to reach Canada via the Lola Pass. Slim is against Jess helping so he refuses to share his map of the trail. However, he relents under pressure against his better judgment.

A gunfighter comes to Laramie and picks up his mail in care of GENERAL DELIVERY to see who he has been hired to kill.Jess knows him and confronts him to see who he was hired to kill.He is injured on the Sherman ranch and Andy tries to reform him.

A drought and the end of the stage line force Slim and Jess to join a cattle drive run by a stranger with their own herd in order for the ranch to survive. Jess is impressed with the hard nosed trail boss but they soon become suspicious.

Slim's lack of attention opens his beautiful girlfriend Kitty to Vince Jackson who is a handsome, charming, fast gunman who has his sights set on her with extortion in mind from her father who owns the stage line and is Slim's boss.

Slim and Jess help a family group of entertainers from Japan traveling east when their wagon breaks down. They have found a boy Mike whose parents were killed my Indians. A trio of men are following the troupe thinking they have opium.

Jess is framed for a murder after threatening a rancher who reneged on the sale of horses. Fearing he is going to be lynched, Jess escapes a posse only to land in an isolated outlaw hideout with outlaws he must join to stay alive.

Jess is in charge of a stage taking $50,000 from Laramie to Denver. A couple of outlaws develop a novel way of robbing the stage by blowing it up. Jess must track one of the outlaws who is wounded with the money to a strange setting.

Slim, Jess and Sheriff Corey shoot down an outlaw, who turns out to be a teenager. When the townspeople learn that their sheriff has been shooting children, they think it's time to replace him.