When Spider-Man is trying out the X-Men's Danger Room, things start to go wrong when a strange intruder named Cyberiad shows up. It turns out that he is Firestar's former boyfriend and he blames her for his current state. Since Cyberiad has control of the X-Men's mansion, can the X-Men succeed in defeating him?

The Spider-Friends are hired by the counter-terrorism agency S.H.I.E.L.D. to capture a mutant named Lightwave, who is said to be after the Guarstar satellite. Lightwave who turns out to be Aurora Dante, a half-sister of Iceman/Bobby Drake. The Spider-Friends and S.H.I.E.L.D. agents learn that Lightwave (whose mutant power is to control and manipulate light energy) is being controlled by someone else who is after the Guardstar.

Captain America, Shanna the She-Devil, Namor the Sub-Mariner, Dr. Strange, and the Spider Friends face off against The Chameleon on Wolf Island.

Norman Osborne's plane crashes, causing him to change once again into the Green Goblin. He decides his new evil plan will be to pollute the resevoir with the same formula used to create him, thereby making an entire city of goblins.

While The Spider-Friends are vacationing, The Sandman shows up and discovers Spider-Man's true identity, but the Spider-Friends try to convince him that he's wrong.

The X-Men have a reunion, which Ice Man and Firestar attend.

Spider-Man meets whom he believes is the love of his life - an alien from the future named Ariel, whose spaceship crash-lands on earth. As Spidey tries to nurture his relationship with Ariel, Doctor Octopus steals the spaceship to carry out a plan to kidnap well-armed criminals from the future.

Dr. Doom unwittingly enables an old man with powers which he uses to his bidding.

When a meteor crashes to Earth mutating the inhabitants of a nearby bee hive, the result is Swarm. A living creature composed entirely of the bodies of thousands of bees, he is bent on turning Earth's entire population into humanoid bees.

When unfortunate accidents stop movie-maker Sam Blockbuster from completing his Spider-Man movie, Mysterio is revealed as the source of all the previous mishaps during shooting. Mysterio blackmails Blockbuster into hiring the real Spider-Man to star in his own movie.

The team meets the Japanese superhero and battles his evil uncle's fire monster.

The Gamesman has developed a machine that will hypnotize young people through video arcade machines. Through a glitch, caused by Gamesman's machine, in the arcade machine a young, nerdy teenager named Francis Byte was playing, Franis developed the ability to turn himself into a self proclaimed hero called Video Man. Unfortunately he doesn't know how to be a superhero. While battling Thee Gamesman, the Spider-Friends help Video Man out. But in the end, the best help is found at the mansion of Professor Charles Xavier.

Dr. Faustus and The Kingpin use "Psycho-Disks" in order to mind control Captain America and Iceman into doing the Kingpin's bidding.

This episode tells us the origin of Iceman from his first use of his powers to the time he was with the X-Men after somehow losing his powers before telling the Spider-Friends his origin.