Depressed over Crystal, Johnny meets a girl named Frankie Raye, who possesses the same powers as he does. Meanwhile, Terrax attacks Manhattan and demands the Fantastic Four fight Galactus. The team learns from Galactus that Terrax betrayed and poisoned him. The poison takes it toll and Galactus will have to feed on Earth.

A nuclear explosion caused by Doctor Doom causes the Fantastic Four to lose their powers. Reed's efforts to restore their powers is cut short after Doom takes over the Baxter Building. The team will need the help of Daredevil to retake the Baxter Building and get their powers back.

Natural disasters are raging on across Earth. The Fantastic Four head off into space, finding Thor and the source of the problems, Ego. The Fantastic Four and Thor can't stop them on their own and will have to rely on one person: Galactus.

The enigmatic Watcher warns the Fantastic Four of the impending arrival of the herald of Galactus, the Silver Surfer. They learn if he summons his master, all of Earth will be devoured.

The Frightful Four have arrived to destroy the Fantastic Four. They take control of Ben's mind to turn him against the team. Can the Fantastic Four overcome this threat? And who exactly is Medusa?

Bruce Banner is in town, which means the Incredible Hulk is too. When the Hulk goes on a rampage, Ben gets in his way.

As Galactus' plans unfold, the Fantastic Four try to reason with him, but it proves futile. The only way to defeat Galactus now, puts Johnny's life in mortal danger. Meanwhile, the Silver Surfer sees Alicia and his loyalties begin to change.

Sue needs life saving surgery and only her father can perform the operation, but he has been in hiding for years since being accused of murder. When he comes to help, he gets arrested after the operation. Meanwhile, the Skrulls release Super Skrull, who takes Franklin Storm's place to exact revenge.

The Impossible Man is on the run from Super Skrull. Johnny agrees to protect him if he tells Lockjaw to teleport him to the Great Refuge to see Crystal.

A creature named Annihlus appears in Reed's lab, soon followed by his mortal enemy, Blaastar. The Fantastic Four learn these two enemies come from the Negative Zone and must return them before it's too late.

The Fantastic Four are at a charity function at Rockefeller Center, when the building is dragged underground. It's discovered that the Mole Man is responsible and he plans for world domination.

Doctor Doom steals the power of the Silver Surfer, becoming empowered with cosmic power. How can the Fantastic Four stop him now?

Reed, Johnny, and Ben arrive in ancient Greece, with only forty-eight hours to find the casket. Their problems multiply, however, when they get into the middle of the Battle of Thermopalye.

The Skrulls let loose a new danger for the Fantastic Four to face, a being that possesses their combined powers: Super Skrull! Will the team be able to take this villain down?

Namor, the Sub Mariner, rises from Atlantis onto dry land. He encounters Sue and kidnaps her, wanting her to be queen of Atlantis.

The Skrulls, a race of green skinned shape shifters, come to Earth and impersonate the Fantastic Four. They attempt to discredit them, hoping to keep them from interfering in their plans to conquer Earth.