As doctors and as humans, the five friends each face a maze of life's questions and decisions as they figure out their next steps.

A series of tough choices and sudden crises keeps life at the hospital as busy as ever. Through it all, the five friends continue to follow their hearts.

One of the hospital's doctors is rushed into the emergency room. A patient with an unanticipated condition poses a challenge for Song-hwa and her team.

The five friends leave for vacation together, but not all of them make it to the destination. Jae-hak and his wife navigate one surprise after another.

Worries about Ik-sun plague Jun-wan's ever-busy days. While watching over a patient post-surgery, Heo Seon-bin experiences a critical lesson.

Distracted by a problem in his personal life, Do Jae-hak struggles to get through the day. Meanwhile, Chu Min-ha finds herself drowning in work.

Jeong Rosa fears the worst when her memory continues to decline. Song-hwa grapples with the unforeseen diagnosis of a loved one.

Five friends whose friendship goes back to their days in med school are brought back together when a phone call interrupts each of their busy lives.

For the first time in 20 years, everyone's finally working under the same roof. A patient with a familiar name finds Chae Song-hwa.

The hospital's med students are inspired by the doctors, who each look after their patients in their own ways. Lee Ik-jun gets a welcome visitor.

An urgent case involving a liver transplant between a father and son is brought to Ik-jun's attention. Jun-wan has big news for one of his patients.

Ik-jun’s team deals with a patient’s anxious brother — and his overbearing attitude. Chu Min-ha leaves a bad impression on a visitor in the cafeteria.

Yang Seok-hyeong's aloofness frustrates someone on his team. Jang Yun-bok and Jang Hong-do witness a surprising side of Song-hwa outside the hospital.

An unforeseen problem just before a surgery forces Jeong-won to make a tough decision. Meanwhile, Jun-wan is put on edge in the operating room.