Supertrain makes its inaugural run from New York City to Los Angeles, but a murder, a mob assassin, and mistaken identity threaten to derail the journey.

A deranged man plans to repay a kindness by killing the estranged wife of his benefactor.

A young reporter who falls for a mysterious passenger, unaware that she is a crown princess being stalked by two assassins with a mission to see that she does not leave the Supertrain alive.

A presidential candidate is secretly abducted by his identical twin — a man anxious to pose as his office-seeking brother.

Film producer Jack Hogarth has to convince his ex-wife, movie star Tammy Tyler, to star in his latest picture to get a couple mob enforcers off his back. Problem is, Tammy and the two goons have boarded Supertrain, but he hasn't.

Despite having professional protection, heiress Natalie Smithburne finds herself on the run from former servants. When she bumps into shy gynecologist Marshall Fossberg, she convinces him to stay in his cabin.

Flood gets the mumps, so his new Executive Operations Officer, Wayne Randall, has to take over on his maiden trip aboard the Supertrain. Penny Whitaker oversees Audrey Fuller's fashion show when an emerald necklace is stolen.

Supertrain hosts the televised International Poker Championship. Five of the world's best players compete, but one has been replaced by a mysterious woman.

A murder suspect and his minder, a women's magazine writer, a honeymooning couple and a pregnant woman get involved in an impromptu hostage situation on Supertrain.