Chaos descends on Phoenix as two serial killers compete for the media's attention and the bodies pile up faster than the police can investigate.

A killer crisscrosses the Midwest leaving a string of victims along the interstate. When investigators are hot on the highway killer’s trail, the murderer suddenly changes his mark.

A serial killer taunted Wichita, Kansas for decades with brazen letters taking credit for his horrific kills. At the introduction of the computer era, the killer gets sloppy and accidentally leaves a digital clue behind in his final taunt to police.

Twin Cities, MN, police are hunting for a killer caller who confesses to a string of murders in a chilling, high-pitched voice, begging for forgiveness. No one can identify him until one woman survives a brutal attack.

When the Hillside Stranglers are caught police realize they still have another serial killer running rampant in Los Angeles; he tortures and toys with his model victims while keeping pieces of their jewelry as he snaps their last photo ever.

After multiple men are discovered brutally murdered, investigators determine that each victim was last seen with a handsome stranger they met in a bar. Police ask the public for help in tracking down a dangerous drifter before he kills again.

Investigators in East Baton Rouge, Louisiana, hunt for a serial murderer who carefully carves up and cuts the bodies of his victims after death.

Police find a string of murdered women in shallow graves in very remote areas of the Alaskan wilderness; after months of searching, police zero in on a local family man living a double life that no one suspects.

El Paso investigators race to track down a ruthless killer that is burying his victims in shallow desert graves, dead or alive.

A killer hijacks the highways of Sacramento as several women are found strangled with their clothing cut into precise but odd patterns; a survivor leads police to a sports car driving deviant posing as a good samaritan to poach potential victims.

Investigators in East Baton Rouge, Louisiana, hunt for a serial murderer who carefully carves up and cuts the bodies of his victims after death.

When multiple victims' bodies are dumped around Louisiana's bayou area, a task force is formed to catch a killer who police believe may have strangled over 20 men.

Police in Hartford, Connecticut investigate a string of ruthless killings in the Asylum Hill area committed by a killer with a devastating mark that leaves his victims nearly unrecognizable.

A serial sniper terrorizes the entire D.C. metro area by discreetly targeting random victims out in public and in plain sight.

A killer is murdering and mutilating young women along the Route 40 corridor in Delaware. But when investigators set up an undercover operation, the hunter soon becomes the hunted.

When multiple victims' bodies are dumped around Louisiana's bayou area, a task force is formed to catch a killer who police believe may have strangled over 20 men.

Police in Hartford, Connecticut investigate a string of ruthless killings in the Asylum Hill area committed by a killer with a devastating mark that leaves his victims nearly unrecognizable.

A Houston killer taunts the media and authorities as he uses homemade ligatures to murder his victims.

In the 1990s, New York is on edge as a killer leaves coded clues at crime scenes and declares his compulsion to choose victims by their birth signs. Police race against time before he can achieve twelve killings to complete the Zodiac.

A series of women in the Seattle area are found brutally murdered, their bodies posed. Police realize they may have a killer stalking the area nightclub scene, one who is able to charm his victims into submission