On the day of Charmaine and Nick's wedding, long-held secrets come to light, while Kate and Marshall accidentally make a discovery of consequence.

The discovery of Tara's new dangerous alter makes Dr. Hattaras and Tara consult another professional. Marshall finds out that his short film hurt his father's feelings and Charmaine connects with "chic moms," while Kate tries to make her relationship with Evan work.

When Bryce takes over, Tara's new alter threatens to destroy the whole family. When Tara's other alters disappear one by one, Max decides to fight off Bryce before it's too late for Tara.

The family is under the impression that Tara’s parents, Bev and Frank, are visiting to celebrate Charmaine’s birthday but when Frank approaches Max about taking the kids to live with them, Max does everything he can to prevent Tara from switching. At the party that night, Tara learns of her parents’ plan and is hurt that they think she is an unfit parent. Sweeping her feelings under the rug, she remains calm however, later that evening, Max wakes to find something that changes everything.

The stress of juggling school and Charmaine's baby shower causes Tara to transition, with negative consequences for Charmaine. To sell the family business, Max must get the approval of his eccentric mother. Kate meets a flight attendant who inspires a new idea about her future.

An upcoming visit from a social worker has its effect on Max. Disapproving Kate's friendship with Lynda, Tara interferes while Neil learns that Charmaine is pregnant.

A new alter comes to light that put Charmaine's new baby at risk. Soon later, Alice visits Dr. Hattaras and intrigues him in Tara's case again. Kate, Max and Marshall fly to New York where they get to meet Kate's new friend Evan and his son.

Tara and Charmaine are rushed to the hospital in the same ambulance, where Charmaine declares her baby off limits to her crazy sister; Tara attempts to make a deal with her alters, which intrigues her Abnormal Psychology professor; Marshall, Lionel and Noah put Charmaine's empty house to some creative uses; Kate is embarrassed to confess that she backed out of going to Japan.

Her psychology professor humiliates Tara when she transitions in his class. Meanwhile, Kate considers giving English lessons in Japan and Max gets a business offer.

Max is worried when Tara returns to college to finish her college degree. Meanwhile, Charmaine with a baby on the way is avoiding a commitment to Neil, Kate tries to figure out a plan for her future and Marshall and Lionel sign up for a filmmaking class.

Tara re-emerges but the task now is to repair broken family relationships, particularly with Marshall who is fed up with it all. Rather than go into a local mental health facility, she decides to follow Dr. Hatteras' advice and see a specialist in Boston. Neil and Charmaine are moving to Houston and offer to take Marshall with them. Kate receives an offer to move to St. Louis. As a new family dynamic emerges, everyone contemplates and wonders what the future may hold.

When Tara and Max can’t connect in the bedroom, Tara worries Max may be more interested in her alters than her. After gaining reassurance from her therapist Dr. Ocean,Tara plans a “sex date” with Max to get them back on track. Tara’s sister Charmaine recommends she meet her new boss for a potential mural project. As Tara prepares for her “sex date” with Max, the pressure becomes too much and she becomes “Buck.” That night, “Buck” doles out advice on women and Max ends up male-bonding with his own wife.

Max’s violent outburst comes back to haunt him. Tara learns she is now able to be aware of what her newest alternate personality, Shoshana, does. Kate’s music video is an internet success. Marshall decides he has to break up with Courtney. The doctor gives Charmaine surprising news about her pregnancy.

Max has his hands full while “Alice” is out again. Marshall fears Jason’s father knows about his crush on Jason. The boys grow closer, albeit platonically. Max decides to embrace his time with “Alice,” even though he misses his wife.

Season two opens with a bang as the Gregsons' neighbor commits suicide and the family unexpectedly is given responsibility of the house. Now well and dissociation-free for several months, Tara sets out to make new friends with Max's help. Marshall struggles to fit in at school while Kate lands a new job. Nick pops the question to Charmaine

Tara starts working on a family portrait in order to re-connect with her family while Max tries to get away from Pammy.

Needing a break from real life, Kate and Tara head out on an impromptu road trip. Max uses this time away from Tara to search for answers about her past. That night, Tara and Kate get into an argument causing Tara to transition into “T.” “T” heads to the nearest tattoo parlor and Kate tries to stop her before she makes a permanent mistake.

Charmaine has decided to get her breasts re-done and has asked Tara to be her caretaker while she recovers. Kate gives Marshall Love advice, telling him to play hard to get with Jason. When Charmaine wakes after her surgery, she is surprised to see “Buck” at her bedside, not Tara. While “Buck” takes care of Charmaine, she comes to appreciate him in a way she never has before.

Tara and Lynda make preparations for their art show. Kate sets up a new business, while Lionel and Marshall's friendship deepens. In the meantime, Charmaine struggles trying to balance Neil and Nick.

Tara feels like a failure as a mother when she is unable to counsel her children about school and sex, so she turns to her perfect-homemaker personality "Alice" for help.

Tara sets out to find a new therapist as Max struggles to come to terms with Buck’s affair. Marshall and Courtney take their relationship to the next level. Tara and Max disapprove of Kate’s friendship with Lynda. Charmaine tells the family some big news. A new alternate personality is born.

Tara tries to drop her Abnormal Psychology class but instead receives an intriguing pitch from her instructor, Dr. Hattaras; Charmaine and Neil find parenthood a struggle but still refuse Tara's help; Max finds himself at odds with his boss at his new job; Kate prepares for flight attendant training; Lionel catches Marshall with Noah, jeopardizing their student film project.