Hamilton embarks on a quest to answer the most important question in ethnoherpetological history and along the way, he finds the power of love.

Hamilton meets an unsung hero of the psychedelic underground and hears a tragic tale of MDMA synthesis and chemiluminescence.

Hamilton heads to India to see industrial Ketamine synthesis, and speak with therapists and luminaries in an attempt to understand the role of dissociative anesthetics in society.

Haunted by past mistakes, Hamilton embarks on a journey to correct an error in his reporting and identifies the origin of an international toad venom smoking phenomenon.

Hamilton travels across North America to study how and why DMT exists in the environment and the laboratory.

From the greenhouses of Thai cactophiles to the Tamaulipan thornscrub, Hamilton traces the history of peyote with the help of a Native American peyotist.

After revealing a scientific mystery around Tramadol-addicted cows in Central Africa, Hamilton follows a Gabonese opiate addict to a psychedelic ritual.

Succumbing to viewer requests, Hamilton journeys to South America to understand the legend of Bufotenine, the world's oldest psychedelic.

Hamilton traces the multibillion year history of nitrous oxide on Earth and follows the strangest noble gas to the Czech Republic.

From X-ray crystallography to vesicular dopamine release, Hamilton travels the country visiting meth labs in order to understand the process behind a great American folk art.

South Africa is the last place on earth Quaaludes can still be found; Hamilton travels there to study the drug and learns of a dark history of medical experimentation.

With the precise structure of LSD's molecular target identified, Hamilton discusses the new era of psychedelic research and meets pioneers of the field.