Ozzy is planning his final world tour, but is hounded to do press, promos and photos which he hates. He tries to persuade Jack to hit the road but Jack has one problem–his new baby is due to be born and he can't leave LA. Ozzy and Jack conspire to convince his sister, Kelly to take the wheel if Jack has to stay behind.

Jack travels once again with Ozzy and his sister, Kelly, now that his baby has been born. They explore the state of New Mexico, sampling chili milkshakes, chainsaw sculpting, and learning to make pistachios. Kelly hates dealing with all the guy humor that Ozzy and Jack deal out, but figures out a way to make a profit from it.

Jack has a big surprise in store for his father's birthday and pulls a lot of strings to put together the perfect trip for him; the trip includes medical oddities, a penitentiary, a voyage 220-feet underground, and a relic from Ozzy's past.

For the first time in the show’s history, Kelly heads the trip. They go to Nashville, Tennessee. Jack and Ozzy are backseat to some very “Kelly” activities, including a drag queen brunch; visiting Manuel, Nashville’s iconic fashion designer; and restyling Ozzy’s Madame Tussauds’ wax figure. Not entirely excluding her father and brother’s interest, they visit a chocolate and record pressing factory. Kelly plans a musical surprise for Ozzy and makes a trip to the largest ashram in the country.

With Jack stuck in L.A. waiting for his baby to be born, Kelly and Ozzy head for Arizona. They tour the impressive Biosphere, followed by a night of beauty masks.

Ozzy and Jack go to a NASCAR race, but the RV breaks down, so a racing expert from Georgia comes to theuir rescue, gives them a place to stay for the night and teaches them about dirt track driving. Later: Ozzy and Jack visit an Elvis museum; drive tanks; and visit a guitar diddley bow artisan before heading to Texas for the NASCAR race.

Ozzy and Kelly are awoken by a call from Jack that his new baby is going to be born; after returning to Los Angeles, the Osbournes manage to welcome a new family member, squeeze in a quick camping trip to Joshua Tree, and even have dental surgery.

In Missouri, Kelly takes the guys to eat some fresh ice cream, while Jack arranges a trip to an "explosion school"; Jack and Kelly plan some touching surprises for Ozzy; old nemesis "Robert the Doll" returns and threatens to derail the trip.

Ozzy and Jack are headed to Mars! Or at least the Mars Desert Research Station in Utah. As the men traverse one of the most beautiful states in America, they must also endure the long drive to San Rafael Swell, where the research station is located. Along the way, the duo visit Jack’s survival expert friend in hopes of learning skills for any sticky situation. They also take time out from the road to spend the night in a native American teepee… complete with flat-screen TVs. When they finally make it to the research station, will Ozzy and Jack survive life on Mars?

Jack reveals their new ride, which is a Mercedes RV, and the guys head to Kentucky. Later: they spend a day at a jumper breeding ranch; visit the the medical oddities museum at Transylvania University; and walk through a life-size replica of Noah's Ark.

Ozzy and Jack trek to Jamestown, Va., taking a few detours along the way; while Jack intends to find out whether any Osbournes were among the first American colonists, Ozzy obsesses over the idea that early settlers resorted to cannibalism

Ozzy and Jack pack up a camper and travel to Roswell, N.M.; while Jack is a true UFO believer, Ozzy is a skeptic; while in New Mexico, they vist the Petroglyphs National Monument, the UFO Museum and the famous Roswell crash site.

Hitting the Pacific Northwest, Jack and Ozzy learn about competitive lumberjacks. Then Jack finds himself bed-ridden with the flu. So Ozzy steps up and visits a coffee roaster himself and gets super caffeinated. After Jack recovers, they visit an oyster farm and then visit a medium who has agreed to tell them if Robert the doll is evil.

Ozzy and Jack head to the United Kingdom; Ozzy seeks to get his hands on Alan Turing's Nazi code breaking machine; Jack tries to convince his father to go to a monument known as Superhenge; Jack pursues his dream of getting his father knighted.

The guys head to Hawaii with their wives to thank them for holding down the fort in their absence. Before long, Jack and Lisa's two young daughters manage to turn every moment upside down; and Sharon and Lisa plan a surprise luau.

While on a road trip to Mount Rushmore, Jack and Ozzy engage in a quick-draw shootout, pan for gold, visit Wild Bill Hickok's grave in Deadwood, S.D., go inside a Minuteman nuclear missile site, and come face to face with Crazy Horse