In Sullivan County, TN, deputies are on the hunt for a man who allegedly assaulted his girlfriend and a father under the influence of a designer drug known as "bath salts", and his erratic behavior makes for a difficult arrest.

Sullivan County, TN and Ashe County, NC in the Blue Ridge Mountains of Appalachia have their share of hardships. Law enforcement takes a "tough love" approach to end local crime brought on by methamphetamine and prescription drug addiction.

A dangerous manhunt in Sullivan County, TN leads to the arrest of a man in his twenties charged with raping a woman in her seventies. In Ashe County, NC deputies work the bar scene to defuse fights.

Within 10 days, three pharmacies are robbed of prescription painkillers. Sheriff's deputies and detectives try to determine if a single suspect is responsible for all three robberies.

In Ashe County, North Carolina, deputies attempt to bust an alleged drug dealer. In Sullivan County, Tennessee, Deputy Sam Matney acts on a tip that residents of a home may be 'cooking' and using methamphetamine.

Witness the raid of a suspected residential meth lab with Sullivan County, Tennessee, deputies and the narcotics team. Just across the border, in Washington County, Deputy Shull is responding to a hold-up at an adult novelty store. Then, it's fugitive apprehension day in Sullivan County! Deputies devote one day a month to finding and arresting Sullivan County's most wanted.

In Sullivan County, Tennessee, and Ashe County, North Carolina, justice is served up Southern style. In these county correctional facilities, many of the inmates are regulars. This includes Johnny Grubb, Don Nixon and Savannah Ramey, who are all on a mission to get clean and make this their last time behind bars. Within these walls, good behavior is rewarded with increased freedoms. Johnny and Don are determined to stay out of trouble and earn trustee status

In Clay County, Kentucky, Sheriff Kevin Johnson and his deputies are anticipating a very busy weekend. Officers get a tipoff that leads them to a meth lab in the countryside. Also, a domestic violence case turns into a police chase on foot.