Daisy thinks she may have been a cause of Conor's break up with his girlfriend, Siobhann, as well as his accident, after Siobhann warns Daisy to stay away from him. Cara tells Daisy that she didn't give Conor the wrong signals. Patrick reassures Daisy she's not to blame for what happened with Conor and needs to talk to him. Daisy talks to Conor and is relieved his self harming had nothing to do with her.

Cathy and Ed attend Mary's funeral. The event gives them a chance to talk about their own grief over the baby. Back at the clinic, confusion reigns while the doctors are away. Mrs Fleming finally understands the truth about Fiona and apologises to Cathy and Ed for misjudging them.

Dan becomes increasingly reliant on his drug habit. He turns to Susie for help but she calls him a coward. Patrick meets Sean's mother Ann Connell and a family secret is revealed. The staff attends a hospital party and Daisy gives Brendan a makeover, with startling results.

Brendan takes his grandmother home from hospital after she confesses that she knows she is dying, but wants to do so in her own bed.

Susie's life is changed totally with the unexpected arrival of her teenage daughter Moya, who has decided to leave her home with Susie's parents and move in with her mother.

Dan's last day at the Clarence Street Clinic is anything but uneventful as his nemesis Diarmuid and Lucille arrive at his surgery and demand that he treat a bullet wound that Lucille has received. When things don't go Diarmuid's way he takes the Clinic staff hostage and makes Dan and Edel operate under gunpoint. When Daisy argues with him he hits her forcing Ruairi to attack him which results in Diarmuid shooting him in the stomach. Daisy begs Dan to help Ruairi and although under threat of being shot he brings Ruairi outside and calls an ambulance as the Gardai storm...

Rumour and speculation spread like wildfire about The Clinic's HIV-infected doctor causing cancellations and panic. Lorcan disappears and it is up to Clodagh to tell Madison about her dad's condition before she hears about it from others - she takes the news badly but in the end she and Clodagh track Lorcan down. Dan tells Daisy that he and Cathy knew of Lorcan's HIV status and asks now that they take action and have him removed from the Clinic before the practice goes under. Dan performs a double mastectomy on a young woman whose family has a chronic history of ...

New general surgery doctor Edel Swift deals with a litany of emergencies that walk into the Clarence Street Clinic and Dan is quite taken by her but he is also obsessed with Lucille and even more so when he finds he cheated at poker and she now owns his shares. Elsewhere, Lorcan finds out that Annie has tested positive for HIV and has to break the news to her but the stress of it makes him take it out on Clodagh. As a result of Annie's test Dave turns up and threatens him again with exposure but Clodagh intervenes and tells Dave that he also is HIV and she had him ...

Having had his advances turned down by Daisy and having broken up with Alice Dan turns to gambling and meets the mysterious Lucille. Ruairi and Daisy become closer as they paint the clinic's conservatory. Lorcan is brought further under the influence of Dave and ends up dealing with a known drug dealer to get methadone for him. Clodagh's first stint as a medical radio D.J. marks an eventful time for her and a patient she deals with online. Meanwhile, new doctor Dr. Edel Swift has major plans for the clinic, Alice quits as nurse in the practice and Grace has to deal ...

Ruairi's dad Franny's condition deteriorates faster and after seeing his old friend Al in the early stages of dementia asks Grace to up his morphine to ease his symptoms so that he doesn't have to depend on Ruairi and Terry. Madison develops a crush on Fergus. Dave continues to use his knowledge of Lorcan's HIV status to get preferential treatment. Meanwhile, Alice becomes jealous of Dan's attention to Daisy. Elsewhere, a striking blonde visiting the Clinic arouses Dan's curiosity. Franny dies in his wife's arms after his big party and Ruairi discovers afterwards that...

Dan is up against the Medical Council for his hearing. Alice is upset when she finds Dan has turned to Daisy for support on the day of his hearing. Dan blackmails Lorcan to be on his side when he is called to testify but will Lorcan comply? Meanwhile, Ruairi helps his dad Franny build a sun-deck for Grace but Franny's condition gets progressively worse but does not tell Ruairi.

Daisy starts monitoring the Clinic's cash-flow and is less than happy with her findings. Dan takes on the complicated surgery of a young African boy with a deformity that could kill him. Ruairí's dad Franny goes to see Patrick and he encourages him to enjoy his last few months by drawing up a 'bucket list'. Meanwhile, Cara forges a prescription for a long-standing patient but is found out leaving Daisy with no option but to give her a verbal warning. Elsewhere, Dave blackmails Lorcan to giving him cash in return for him staying silent on his HIV status.

Dan is questioned by the Gardai over Niall Boylan's death but is eventually released only to incur the wrath of Daisy about his involvement in supplying cosmetic surgery products at inflated prices. Lorcan supports Dan which Daisy doesn't understand but Dan is holding a trump card - Lorcan's HIV status. Elsewhere, Lorcan's daughter Madison moves in with him.

Dan and Daisy face Niall Boylan in court but later find out that he has been killed. After Alice lets slip about Lorcan's HIV status Dan confronts him. Later, Dan is arrested for Niall Boylan's murder.

Fergus Mitchell, a teenager claiming to be Patrick's son is mugged and beaten up and asks for Patrick when at the hospital.But Bernie doubts his story but Patrick isn't swayed. Elsewhere, Julia agrees to run for job of Hospital Director and when she gets the job she offers her shares to Lorcan and Cara steps in as birth partner to Fiona. Meanwhile, Lorcan and Clodagh decide to go out on a date.

Alice secures a temporary role as the nurse in the clinic, and is keen to celebrate with Dan. Annie Ward brings her ex-boyfriend, Dave, to the night clinic in an effort to wean him off heroin with disastrous consequences.

Liam continues taking Rocusin, and even steals a prescription from one of Grace's patients. After giving wrong medication to another patient, Liam blames Grace and convinces the patient to back up his story. Julia takes Liam's side in the matter. It takes Alice to recognize that it is Liam that is at fault and she goes to Lorcan about his behaviour. After being confronted, Liam admits to his drug abuse and it leaves Julia with no option but to suspend him from work. Elsewhere, Aideen doesn't turn up at the airport and later tells Dan to leave her alone. Later Dan is ...

Ronan and Keelin's lives are turned upside down when a senseless attack on Ronan by one of Ian's friends leaves him potentially paralysed. Meanwhile, Liam's addiction begins to get worse and cracks begin to appear in Daisy and Conor's relationship as Daisy struggles to juggle her work with her home life. Elsewhere, Cara struggles with what she did to Hope and Kieran.

Keelin has to face up to the news about her mother's cancer. She realises that her family cannot cope and she has to give up her single lifestyle and move back home to care for Mary, a difficult woman whom Keelin has never got on with at the best of times. Fiona goes further off the rails, and Cathy is forced to dismiss her.

Patrick's long-running case with Seán, plus his constant work load, takes its toll on his own mental health. In addition he has to face Seán's father who resents the disruption caused to his family life by the disclosure of the secret. The usually calm Patrick shocks everyone by his behaviour.

Today is the anniversary of the day Cathy gave birth to a stillborn baby. Cathy and Ed's grief is private so much so they can't even talk to each other about it. Very few people at the Clinic know about the stillbirth.

It's Ed's birthday and the day starts off with him catching a junkie breaking into the surgery. Mrs Fleming is rattled by the burglary as the boy gained access through her flat.

Alex considers starting a thing with local barman, Michael. His carefree existence is abruptly shattered however by a needle stick incident. The thought of contracting Hep C from the needle and having to give up the job he loves turns Alex into an unrecognisable nervous wreck, much to everyone's surprise.

Dan returns to Dublin and looks to make up with Susie, but soon discovers she has gone to Thailand. Cathy prescribes penicillin to a patient, not knowing the serious effect the drug will have on them.

Clodagh, the new GP, has a bad start to her day when she knocks Ed over. Her day goes from bad to worse when she suspects a patient has an ectopic pregnancy, but is overruled by Cathy's father, Mr O'Callaghan.

Things are hotting up as affairs start rising to the surface. Paul tells Keelin he knows about her and Ed and begs her not to say anything to Yvonne about his carry on at the stag party. Meanwhile, Cathy tells Ed she might be pregnant and in turn Ed tells Keelin the news, who lets a congratulations slip to Cathy! Meanwhile, Yvonne hears Keelin and Paul fighting about his stag night antics and loses her temper with Keelin and tells her she doesn't want her to be her bridesmaid any more.

Dermot asks Fiona to join him for lunch. Cathy is interested in buying next door and goes to her Dad in the hope of interesting him in investing.

Ed finds Cathy's pills in her drawer and concludes that they have different ideas about wanting a family. Cathy visits the bank and realises that they will have to let staff go if they are to service the loan that she hopes to get to cover her dad's share.

Ed wakes up in Patrick's flat. He walks home, hungover and meets Cathy out for a run but she ignores him. Cathy confides in Áine that she and Ed are having problems.

Cathy wakes up to see Dan in the next room and wonders what happened the night before. Ed meanwhile wakes up at Patrick's who tells him that he should go home. Dan sees a former patient of Ed's for a cosmetic consultation and suspects she has a thyroid problem.

Fiona is deeply missing Ed and thinks that The Clinic is falling apart without him. In her attempts to save The Clinic she only manages to make matters worse. Cathy too is feeling the aftermath of Ed's departure and is unable to cope with the daily business.

Brendan's inheritance of his Nan's house worth 2.75 million euro has just become official. The other staff in The Clinic question Brendan on what he would like to do with this money. Brendan is happy with his life and has no intention of selling his beloved Nan's house. Everybody has an ambition except for him and he tries to live his ambition through Clodagh.

Patrick is lonely and everything around him is further illustrating how alone he is. Through a chance encounter with an old acquaintance, he learns that his ex-wife Lisa is in town. They arrange to meet. Lisa hasn't seen him sober in a long time and is surprised by this new man. They get on great, the sparks are flying and their relationship takes a new turn.

Clodagh gets some shocking news, her father had an affair and she was the product of it. Daisy takes a fancy to Brendan's replacement, Will Cafferty. Cathy & Dan's relationship develops further.

Keelin has to decide if her business is worth losing her friends. Paul turns up at the Clinic asking Keelin to build bridges with a pregnant Kathleen, she is sceptical at first but is delighted when she arranges dinner with Kathleen. Keelin is furious to learn that Cathy has been referring patients to other physiotherapists.

Mr O'Callaghan's demise is revealed as he plummets from the high of the nomination for his Presidency to the depths of despair when he loses out. He is unable to take any more or to reach out to anybody, most notably Cathy