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Used to nab a serial rapist terrorizing a small English town and to identify one of America's most notorious murderers (the ruthless BTK Killer), DNA profiling has redefined forensic investigation. As science evolves, the ability of genetic profiling to help solve homicides continues to grow. Witness two landmark cases in the history of genetic profiling as scientists and detectives involved in ground breaking cases usher in a new age of forensic science.

One crime baffled a small Argentina town; the other held the entire state of California hostage. The thread that links these two cases occurring 100 years apart: both murderers were done in by their own hand. Specifically, by their fingerprints. Witness the breakthrough moment in 1892 when fingerprinting was first used to track down a child killer and see how the evolving science helped thwart a coldblooded serial killer a century later. Then follow the bloody trail of a serial killer dubbed the Night Stalker and discover how detectives nabbed him with powders, hand-held lasers, and a stroke of luck.

Illinois has played host to two of the most grisly murder cases of the last century. One involving the Sausage King of Chicago and the other the Killer Clown. Both cases were solved thanks to the victims' bones. Forensic anthropologists can now analyze skeletal remains to determine a person's age, sex, ancestry, stature, unique features and more importantly: cause of death. Revisit history's most shocking homicide cases cases as this forensic tool is put to the test, delivering powerful and undeniable evidence that brings countless killers to justice.