Jim stops drinking in solidarity with Steve and starts to suffer from panic attacks. Through a misunderstanding, Jim ends up at a married ex-girlfriend's house for a costume party.

Jim deals with the fall out of being shot by a heckler and considers quitting comedy. Billy goes to a video game tournament.

One of Billy's friends with muscular dystrophy dies forcing the realization on the guys that Billy doesn't have much time left. Jim copes by chasing after the dead guy's sister.

Jim performs a sexual act to get a female executive in Hollywood to help him land roles.

Jim, Billy, and Steve are attacked in their home by two men who think they are drug dealers. The two men are put on trial as Steve, Jim, and Billy recall the events and testify against them.

Jim and Steve create a fake online dating profile to help Billy meet girls; Steve goes to a bar and tests out Jim's pick-up strategies on a co-worker.

When Jim and Steve attend their high school reunion, they find things aren't quite as they remembered. Billy tags along and poses as an able-bodied alumnus.

In an effort to do something nice for Steve, Jim invites him along to a gig in Omaha — but once they get on the plane Jim gets embroiled in a battle with another passenger about plane etiquette and a middle seat.

While running an errand with Steve and Billy, Jim discovers Janice has become a hoarder, forcing her husband Walter to live outside. In a misguided intervention, Jim uncovers more family secrets.

Jim and Steve decide to break Billy out of his adult care facility to party for one more night but their plan goes awry when they are forced to take Billy’s mentally challenged roommate, Rodney, along for the ride.

Jim Jefferies, taking his first baby steps toward legitimacy and trying to do a good deed, treats his close friend Billy — suffering from advanced stage Muscular Dystrophy and confined to a wheelchair — to a debauchery filled road trip to a whorehouse in Las Vegas.

An actress accuses Jim of attempted rape. Later, Steve's wife and daughter move to Cincinnati.

To escape his parents, Jim goes to Afghanistan to entertain the troops and comes under heavy fire with Steve. Billy is hospitalized with Jim's mom.

Walter goes missing after walking in on Billy having sex. The boys search for him and discover one of Janice's secrets.

The van is towed with Billy in it while Walter and Steve go out drinking. Billy's wheelchair is stolen by gang members and Jim and Steve help him get it back.

After missing out on a role because of his weight, Jim turns to his good friend Andy Dick for some career advice, acting lessons and physical training. Jim ends up ruining the trainer.