The first episode features Richard, an amateur radio enthusiast, who has Asperger's. Richard will only date a woman who lives within a five-mile radius, and won't eat on a date. Meanwhile, 23-year old Luke is a stand-up comedian who has Tourette's. He's got an active social life and a good group of friends, but in a world where first impressions are everything, he's petrified of approaching a girl for fear of calling her a slag - or worse. How will Luke cope when he meets Lucy, a part-time receptionist, who's never known anyone with Tourette's before? Trainee teacher Penny, 23, has a genetic disorder that means her bones are extremely brittle. She's never been on a date before, and is worried about getting left behind. Penny is three feet three inches tall. Her ideal man is a 6 foot tall policeman.

The cameras follow Shaine from Bournemouth. He is a prolific amateur poet who suffers with a learning disability and desperate to find love. Carolyne is a bubbly 29-year-old from Greater Manchester who is fed up with always meeting the wrong guy. She woke up five years ago after going to bed paralysed from the chest down after a weak blood vessel burst in her spinal cord. The cameras follow her after she meets a man called Wayne.

The cameras follow media student Sam from Kent who is suffering with Down's Syndrome. The 27-year-old has appeared in the television shows The Inbetweeners and EastEnders and has a supportive family life, but wants to find a girlfriend. The cameras also follow Kali, a 20-year-old singer from south London, has William's Syndrome who is desperate to find love.