Steve DeAngelo and his family run Harborside Health Center - the worlds' largest and most successful Medical Marijuana dispensary on the planet. But when Oakland voters approve a 5% tax hike on all dispensaries, they effectively slap the DeAngelo brothers with a 1.2 million dollar tax bill...due in one week. Steve dispatches his CFO Luigi to city hall to try and fight the battle. If they lose their appeal, it could mean the end of their business. And Harborside "Budtender" Terryn begins growing weed to make ends meet. But when he learns the true demands of being a "patient-farmer", he questions the direction of his life.

While in the midst of a Federal Tax Audit, Harborside Health Center's, Steve DeAngelo learns that the IRS intends to apply 280E, an obscure tax code that will label the dispensary as a Drug Trafficking organization,effectively put them out of business. As Steve and his crew prepare to fight back, The U.S. Justice department begins shutting down neighboring dispensaries. Could these two actions possibly be unrelated, or are the Feds launching a coordinated attack against Medical Marijuana? All the while, Steve's brother Andrew provides a helping hand to the father of an epileptic child as he administers Cannabis to his four-year old for the first time; and Jon, a patient-farmer struggles to save a harvest from a spider mite infestation.

Even though Harborside Health Center is the largest and most successful Medical Cannabis dispensary on the planet, it's still truly a family business. So when Steve DeAngelo leaves his Oakland dispensary for a much-needed two-week vacation, he entrusts day to day operations to the general manager -- his younger brother Andrew. But as soon as Steve's plane lifts off, Andrew discovers an evil voodoo mask, slipping Yelp reviews, and complaints about Harborside's "medicine". Andrew tries everything in his power to right the ship before his brother's return - but within hours of Steve's arrival, Andrew learns of a personal betrayal within Harborside's ranks, that will truly break his brother's heart.

April 20th, known within the Cannabis community simply as "4/20" has been the unofficial international weed holiday for over 30 years - and it's also Harborside Health Center's busiest sales day of the year. As much as Steve DeAngelo loves 4/20 as a day of celebration and booming business, he fears that widespread images of tie-dyed hippies smoking 6 foot joints ultimately damages the credibility of their "medical movement" with the public at large. This year, only three days after 4/20, Harborside Health Center is launching "Deep Green", a festival aimed at characterizing Marijuana not as an intoxicant, but as an aid to wellness. Will their festival dramatically re-brand the public's image of the plant, or simply attract the same old stoners?