Monroe has to confront the prospect of operating on a colleague when registrar Sally Fortune collapses. Bremner reaches a decision about her relationship with Shepherd, and Monroe helps his estranged wife Anna build a new life.

Monroe is still reeling from the result of Lynn Monkford surgery. He makes his decision on who to promote to registrar. Shepard is left to deal with what he did the previous night, he and Bremner decide to try counselling to repair their relationship.

Monroe has informed Bremner after Shepards activites. Witney appears to have decided that its time to leave St Matthew’s. Monroe decides to throw a stag party for his son Nick. Meanwhile at the hospital Springer is introducting Jacob Namobu, a young medical student to neurosurgery. Things don't go to plan when there is a large road traffic accident. This night the truth will be revealed, someone will die, and someone will resign.

Monroe finds that 'civilised divorce' is much harder than he had imagined and his attempts to enter the world of dating seem doomed to failure. At the hospital, Monroe tries to persuade an epileptic man to have an operation that could stop his religious hallucinations, and Bremner is furious to find that she is the subject of gossip about her relationship with Shepherd.

Monroe goes head to head with his new boss when he elects to operate on a patient with a deadly vascular anomaly. Meanwhile, Jenny Bremner returns to St. Matthew's from maternity leave to find the hospital changed - and her power diminished.

A former soldier is admitted to the hospital with a blood clot in his brain and Monroe controversially decides against surgery. Bremner is tempted to break her own rule about remaining detached from her patients, and Springer tries to cover up the fact that he has `mislaid' a patient.

At work, Monroe has the courage to perform cutting-edge brain surgery but at home, he is afraid to admit that his life is falling apart. When Alison Bannister is admitted with a brain tumour, Monroe has to help her make a frightening decision. To go ahead with an operation could leave Alison paralysed or unable to speak, yet without surgery, she is likely to die within a few years. Does she want to survive if surgery might change who she is? And can Monroe get her through this crisis as his own life starts to spiral out of control?

As Monroe struggles to accept the fact that his wife Anna has left him, he throws himself into work and tries to pretend that his life is not in freefall. Can he find the courage to tell his son the truth about why his marriage ended? At the hospital, Monroe and cardiac surgeon Jenny Bremner have to deal with a double shooting after a 14-year-old boy accidentally shoots his 12-year-old brother before attempting to kill himself.