A popular intergalactic circus featuring unique creatures from across the galaxy comes to Acmetropolis to entertain the citizens.

A new villain named Massive uses his ability to control gravity to commit several robberies all over Acmetropolis.

An extremely large iceberg appears and threatens to put Acmetropolis into a new Ice Age. It's up to the Loonatics to save the city before it's frozen over. Who is behind this extreme disaster and why?

Zadavia sends the Loonatics of a mission involving Black Velvet, the new bad girl.

When lightning strikes an overly jealous girl who wanted to be a weather personality, she becomes Weathervane, a being with the power to control weather, and bring forth chaos on Acmetropolis! It's up to the Loonatics to stop her before she destroys Acmetropolis with her "rain" of terror!

The planet is in the grip of Fuz-Z mania when a cute little creature becomes one of the most popular pets in Acmetropolis thanks to Professor Zane, who says that he found them shortly after the meteor strike.

Time Skip, a villain who can control time, plans revenge on the military for stealing his design for the Trolbot 9000.

Drake Sypher possesses the power to absorb the abilities of anyone that touches him, and decides he should be the one person getting the fame and glory of being a hero.

Landing on the island of Apocalypso, the Loonatics find a colony of beautiful, powerful women called the Apocazons led by Queen Athena. Queen Athena was impressed by Lexi's behavior towards Duck, and invites her to join them in a very special event. However, not all is as it really seems with the Apocazons.

Now that Optimatus is free, he alongside General Deuce and Rupes Oberon plan to use Planet Blanc's wormhole generator to take over the universe. Planet Blanc is said to be at the center of the universe, and that every point in the universe can be instantly travled to with ease from it. The Royal Tweetums contacts the Loonatics for help. It turns out that Tweetums evaded capture. The Loonatics must find him before Optimatus does, but not without help from an old enemy.

Pierre Le Pew convinces Slam and Duck that Slam can become a champion fighter in his private tournament. However, he fails to tell them that the last match is to the death. It's up to the rest of the Loonatics to save Slam before it's too late.

The Loonatics have to transport Tweetums, the heir to the throne, to his home planet to end a war. Little do they know is that they are threatened by a force named Sylth Vester and an unknown figure. Both will stop at nothing to see they don't complete their mission.

Zadavia reveals the location of Optimatus' hideout and the rescue on Danger Duck. When Zadavia is captured, the Loonatics must rescue her, save Acmetropolis, and defeat Optimatus.

When Rev and Lexi tamper with Tech's X3000 Automated Weapon System mistakening it for a video game, Melvin the Martian comes to Acmetropolis to destroy it after his spacecraft was hit by a missile from Tech's invention. When Melvin threatens to shrink the planet, Lexi admits she tampered with Tech's invention and Melvin orders that Lexi be handed over to him in 24 Hours. Can the Loonatics find a way to thwart Melvin before Acmetropolis becomes the only planetary location to be "hard to find on any map."

The Loonatics face off against Boötes Belinda, a villain and his band who uses rock music to terrorize Acmetropolis. When Zadavia is captured, he orders Tech to build a high-tech guitar for him. Now the Loonatics must save Zadavia and defeat this evil band. It turns out that the band are robots led by Rupes Oberon, a man who wrote a theme song for Zadavia on Freleng, but was shot down since there already was a theme. He uses the guitar to steal all of Zadavia's powers.

The Loonatics take on an old enemy of Tech: Mallory Mastermind. When Mallory escapes from prison, she swears revenge on Tech. It will take all the genius Tech has to defeat this genius of a foe.