When a young Arizona businessman is found slaughtered in his bathroom, friends point police towards his on-again off-again ex-girlfriend. Facing the death penalty, Jodi Arias takes the stand for an unprecedented 18-days in an attempt to explain how the brutal killing of her ex-boyfriend was self-defense.

In 2006, Ken Juedes was found dead by his wife, Cindy Shulz-Juedes. For 13 years the case went cold until investigators linked her to the murder. Cindy Shulz-Juedes has decided to take the stand with the hope of convincing the jury she is innocent, and her husband's real killer is still at large.

Curtis Reeves stands accused of murdering Chad Oulson over popcorn at a matinee movie; the defense claims he acted in self defense while the state's prosecutors argue that Reeves was short-tempered and unjustified in the shooting.

During a road rage incident, Theodore Edgecomb shoots and kills predominant immigration lawyer Jason Cleereman. Charging him with 1st degree intentional homicide, the state contends it was a cold-blooded murder. Edgecomb has decided to take the stand to convince the jury he shot Cleereman in self-defense. Will the jury believe him and spare him from life in prison?

A year after discovering her husband's frozen body in the driveway, Lori Phillips faces charges for his death; facing up to 25 years in prison, Lori has decided to testify, hoping to persuade the jury that she was fleeing from an abusive man.

An American Dream becomes a tragedy when San Antonio businesswoman Andreen McDonald goes missing. Four years later, her husband, Air Force Major, Andre McDonald, is on trial for her murder. Facing life in prison, McDonald takes the stand. Will the jury believe he's the victim of a domestic dispute gone wrong or a cold-blooded monster?

Georgia high school teacher Tara Grinstead's sudden disappearance in 2005 goes unexplained for 11 years until a surprising statement to law enforcement from Bo Dukes, a former student, names his friend and former classmate, Ryan Duke, as her killer. Fighting for his freedom, Ryan Duke takes the stand at his trial to assert who he says is the true killer. Will his testimony be enough to convince the jury he didn't murder Tara Grinstead?

Romance novelist, Nancy Brophy, faces life in prison for the murder of her husband, Chef Dan Brophy. After finding surveillance video showing Nancy's minivan driving around the time and area of his murder and a blog post Nancy wrote entitled "How to Murder Your Husband," she is arrested and charged one Count of Murder and one Count of Unlawful Use of Firearm. Now, Nancy Brophy is set to testify in her own defense.

Sean Foley stands accused in the shooting death of his girlfriend's step-father, Jimmy Shelton. After a booze-filled evening, Sean fatally shoots Jimmy on Jimmy's own back porch. Sean claims that Jimmy was the aggressor that night. Foley has decided to take the stand to convince the jury that he's innocent, that the shooting was in self-defense and not cold-blooded murder.

In 2019 Delinord Dumercy takes the stand for the second time, claiming that his decision to shoot and ultimately kill James Peoples was in self-defense and not murder. Although this horrific event is witnessed by multiple people and captured on camera, Dumercy's first trial ended in a hung jury. Will prosecutors be able to convince a jury that Dumercy is guilty of murder? Or will they find him innocent after he claims that he was being hunted like an animal by James Peoples all along?

Active-duty Army Sergeant Demarcus Little is on trial for the murder of his ex-girlfriend Anitra Gunn.

Hannah Payne is on trial for the murder of Kenneth Herring, a motorist who fled an accident.

Zachary Wester, a Sheriff Deputy from Jackson County Florida, stands accused of planting drugs on unsuspecting motorists during routine traffic stops. He's been charged with over 65 counts and faces up to 85 years in prison if found guilty. Will he be able to convince a jury his stops were by the book or will he be guilty of betraying the badge and the community he served?

When 3-year-old Hannah Wesche dies of head trauma, the babysitter who cared for her is indicted for her murder.

Exotic animal dealer William "Wild Bill" Zelenski is accused of murdering his girlfriend's 18-year-old son, Ryelee Manente-Powell after he stole $27,000 worth of venomous and exotic reptiles. He claims it was an accident and will take the stand to explain what really happened.

After being sucker punched during a campus gathering, Northern Arizona University freshman Steven Jones shoots four fellow students, injuring three and killing one.

Sasha Skare, 23, is on trial for the murder of her music producer and lover Martell DeRouen. She has turned down a plea deal and decided to take the stand to tell her side of the story--that she was abused, and the shooting was unintentional.

When an off-duty Dallas police officer shoots a man in his own apartment, the jury will have to decide if it was murder or a tragic mistake. Amber Guyger takes the stand in her own defense to convince the jury not to lock her away for up to 99 years.

35 years after 12-year-old Jonelle Matthews disappeared from her home in Greeley, CO, her remains are recovered. Investigators charge former Idaho Gubernatorial candidate Steve Pankey with murder.

Charlie Adelson stands accused of hiring two hitmen to murder his ex-brother-in-law, Dan Markel, in order to free his sister from a nasty child custody dispute; according to Adelson, he's also a victim, claiming the hitmen extorted him.

After 8 months on the run, disgraced personal-injury attorney Richard Merritt faces trial for the brutal murder of his 77-year-old mother, Shirley.

The Wagners stand accused of murdering eight members of the Rhoden family over a bitter child custody dispute. While several members of the Wagner family have plead guilty, George Wagner IV will take the stand and try to convince the jury he played no role in the massacre.

When an entire family is found in a decaying pile of bodies by the side of a Florida road, the hunt is on to find what police fear might be two more victims; a man and his son are found alive, launching a bizarre investigation.

An argument between former NFL player Travis Rudolph and his ex-girlfriend escalates into a gunfight with her brother and his friends. Rudolph will take the stand to claim he had no choice but to open fire 39 times to defend himself. Will a jury believe he was justified or decide he went too far?