Sara is put to the ultimate Witchblade trial. Meanwhile, Captain Dante introduces Jake to a secret brotherhood of vigilante officers who use their own methods to exact justice - will he join with them?

Jake and Sara tail an arms dealer, but a sniper's bullet ends their chase. The case gets weirder when Sara finds a dossier among the victim's effects containing shocking details on Irons, Nottingham ... and herself!

Sara's unlikely protector surfaces with a life-threatening passion to watch over her that leads to irrevocable consequences. Sara has no choice but to accept the destiny that comes with wielding the gauntlet and use it to regain what she has lost. But every gain has its price. True to the words of the Witchblade's past wielders, "Nothing is as it seems". A startling discovery about Dante and his team of corrupt cops lead to a suspenseful showdown between the rising warrior and a band of enemies that she must conquer before her father's killer is revealed.

On the lamb from the NYPD, Sara turns to Jake for help, but is Jake in on the conspiracy against her? Meanwhile, Kenneth Irons struggles to stay alive as he spins out a plot to attain the one gruesome elixir that can save him. Irons reveals his true intentions for Sara and the Witchblade.

Ancient Celtic sacrificial rites are being re-enacted on the streets of New York. Pezzini crosses paths with an Irish rock star named Conchobar whose music is mysteriously linked to the crimes. Kenneth Irons tempts Sara with clues about the murders from a mysterious manuscript.

Sara Pezzini and her partner Danny Woo are once again in pursuit of the allusive mobster Tommy Gallo. As before, Tommy's henchman lures Sara into the museum where she encounters the Witchblade and it claims her as its chosen wielder. This time, however, things are different. Though it's a case of deja vu as she retraces her steps to the Rialto Theater, an older and wiser Sara declines the opportunity to confront Gallo inside. Although the past may be altered, Kenneth Irons has plans for the future and he determines to take the Witchblade from Sara even if it means having her killed. A much conflicted Ian Nottingham finds his loyalties split between guarding the chosen Witchblade wielder and carrying out the wishes of his master/father, Irons. Using an online murder/hit as bait, Irons lures Sara into his clutches while promising an ambitious and cold-blooded woman named Cristina that she will wear the Witchblade if she takes out Sara. To do so, Cristina must first get rid of Danny so she buries him alive, leaving him to die a horrible, slow death. In a Witchblade frenzy, Sara kills Cristina before she can make her tell what she did with Danny. As her partner runs out of air in an unmarked grave, Sara desperately searches for him before it's too late.

As Sara and Danny investigate a series of bizarre drug-related murders, rookie detective Jake is pulled into a sting with a questionable cop. Now Sara must learn to use the Witchblade to solve the crime and save Jake before it's too late.

A killer known only as V tries to take over New York's organized crime syndicates, causing mayhem. But when the evidence gathered at the crime scenes includes the fingerprints of Sara's long-dead father, Sara must trust the Witchblade's powers to overcome her emotions and wage war with the greatest evil she has ever faced.

Learning to adapt to the Witchblade, and her new partner Jake McCarty, Sara Pezzini's role in the Rialto Theater incident is questioned during a hostile meeting with the police review board. Captain Joe Siri makes a big announcement. Sara and Jake tangle with Ian Nottingham over a deranged ex-special forces soldier a "Black Dragon". Captain Bruno Dante is introduced.

A man named Bittner is on the run from two mysterious men who kill him after he sends a message to Gabriel. It turns out Bittner had a tape with evidence convicting the mysterious men and their organization of some major murder. Gabriel and Sara recover the tape, are forced to shoot two of the men who are government types, and go on the run while Sara has visions of a mysterious Boston-accented talking to her about politics and evil. Sara ends up captured by the conspiracy, who are a mysterious cabal who plan on taking over the U.S. She escapes but the conspiracy lets her live in return for a favor, and returns the captive Gabriel to her. At the end her mysterious ghost/man reveals himself as John F. Kennedy before disappearing.

A psychotic serial killer of young girls - who has a fetish for their fingernails - becomes obsessed with Danny's niece. Sara must rely on the Witchblade's visions to find the girl before she becomes the killer's next victim.

Sara experiences love at first sight when she meets a man who is perfect for her. But the affair goes awry when Irons returns from the grave with knowledge of the man's true identity. Sara is faced with an impossible dilemma: Can she kill the man she loves?

Sara and Jake are caught up in the world of high fashion when a stunning young model is murdered. Sara's connection to the legacy of the witchblade becomes more mysterious when she uncovers a link between her past and the dead model's roommate.

A priest is brutally killed, and a young member of his congregation is the prime suspect. Despite the boy's affirmations of guilt, Sara suspects something else is at work. Investigating, she comes to believe that the boy was possessed by demons, and yet she still believes he was not the one responsible. She also fences with Father Del Toro, who has been assigned by the Vatican to investigate. Del Toro seems to know a great deal about the Witchblade as well, from its time when it was kept at the Vatican. Eventually Del Toro is revealed as the true murderer.