In 1987, hemophiliacs untouched by AIDS believe blood products are safe. But one company's heat-treating process proves flawed and seven more people, five of them children, are infected. Brash and outspoken hemophiliac, Jim Krepke joins the fight. Will has a victory while Ben seeks direction. Alice and Peter try to pull themselves together.

Over the early 90's, victims of tainted blood begin to come forward and pressure the government with lawsuits. With Margaret's help, the Hemophilia Society works tirelessly behind the scenes for compensation. Lucky to avoid HIV, Ryan Sanders suffers through the side-effects of treatment for Hepatitis C. Peter meets Darby and despite his HIV, they fall in love. Having finished the archival history, Ben starts work on a more personal book but it causes further rift between him and Peter.

In 1994, Justice Horace Krever is appointed to lead an inquiry into the tainted blood scandal. Shocking revelations and heart wrenching testimony are laid bare as he digs for the truth. Estranged from his family, Ben's quest for revenge is galvanized, as victims around him continue to die. Krever is halted when those he intends to accuse of misconduct take him to court.

The supreme court rules in favor of Krever and his report finally comes out. It names many for wrongdoing and aims to rebuild the flawed blood system in Canada. While victims still suffer and loved ones mourn the dead, at least many feel that their voices were heard and those responsible were held accountable. But Ben is not satisfied and pushes for criminal charges.

As the criminal trial falls apart, Ben considers taking matters into his own hands. Peter and Ryan both struggle with illness while forging families of their own. In 2015, both of their lives hang in the balance as the tragedy finally threatens to catch up to them.