Claudio has a proposal for Alice: he will agree to formalize their relationship and open up to the project of a family with her, as long as Alice leaves the Institute. Alice is stunned: such an either or is impossible to accept. Meanwhile, a crime on a sailing boat brings the pupil and PM Einardi even closer.

During the investigation into the attempted murder of a theater director, Alice senses the reason for the rust between Conforti and Einardi: between the two there is a war that risks involving her. During the investigations, which also bring up Cordelia, Alice's roommate, a formidable scientific intuition of the student reveals the motive for the attempted murder.

Claudio and Alice continue to have opposite points of view on love. Meanwhile Ambra mysteriously disappears and Claudio seems to be very worried. A pharmacy robbery degenerated into murder leads Alice and Conforti to meet Einardi again, who once again does not hide a keen interest in the student. In the meantime, the Supreme Prof. Malcomess, director of the Institute, communicates the decision to retire, opening the race to his succession and calling for a competition among the trainees for a scholarship in Baltimore.

Summer is over and it's time for Alice to go back to the Institute. Among the tasks that Wally immediately entrusts her is that of tutoring Erika, a new resident. In the meantime, human bones are found in the basement of an archaeological area. Alice and Claudio, with whom the girl continues to live a turbulent love relationship, go to the place. Here Alice meets the fascinating PM Sergio Einardi and soon discovers that, between the man and Conforti, there is a mysterious resentment linked to the past.

Giacomo's provisional release re-starts the investigation into the crime at the golf club. Meanwhile, Alice discovers that someone is looking for information on Manes: perhaps the person she so desires to meet is closer to her than she imagines. For Alice and Claudio the day set for the wedding has arrived, but it passes in vain.

Claudio and Alice follow an intuition that can exonerate Giacomo. Paolone is also summoned for his first report: the mysterious death by poisoning of a well-known food critic. Alice's stubbornness, meanwhile, leads her to make one last attempt in the quest that the Supreme had given up.

Alice is destroyed by suspicions of Claudio's betrayal and returns the engagement ring, sending him into a rage. To cheer her up, Wally involves her in her secret project and Silvia suggests reprisals. Meanwhile, a famous trapper is killed just before a concert and the difficult expertise is entrusted to the Suprema herself, who decides to take Alice with her. Sandro sees an opportunity and decides to come forward with Alice, but does not realize that Claudio has seen it all ...

A transsexual is found dead in the courtyard of an apartment building. A single shoe testifies to his last leap into the void. What prompted him to die?

Alice is a young graduate in medicine who does not yet know what specialization to take, nor what to really do in her life. The death of her grandmother's caregiver, which occurred under unclear circumstances, will make her choose forensic medicine.

Alice did it: now she is a specialist in Forensic Medicine! He understood that life inside the Institute will be anything but easy, but soon something new knocks on his door. His name is Arthur.

A new case involves our coroners: a boy in custody dies of respiratory failure following a fatal stroke. Meanwhile, love and work do not run in the same direction.

Could it be true that in love who flees wins? Arthur is gone and Alice, who hasn't heard from him for days, is in a panic. Meanwhile, a diver dies during a competition: according to Claudio it is an obvious case of doping.

A running coach is found dead on the edge of a track. This is a complicated investigation, with a single visually impaired witness. Alice, meanwhile, must reflect on her feelings towards Arthur who reveals that he wants to return to live in Rome just to be close to her.

Alice is intrigued by the arrival of Giacomo, Claudio's brother with a wild and unconventional charm. He would like to know what has divided them in the past, but Claudio does not confide, even now that they are getting married. In any case, Alice's attention, rather than Claudio's reluctance, is focused on the Suprema: she appreciates its rigor and considers it a model of life totally different from what she had always imagined for herself. During the investigation into the murder of a sushi chef, Silvia confronts Alice about her working relationship with PM Einardi. At the institute Erika asks Paolone to help her conquer the fascinating Sandro who instead seems to have a keen interest in Alice. The first meeting between Giacomo and the Supreme generates sparks, leading Claudio to be even more irritated by the presence of his brother.

Alice and Claudio are at loggerheads for Giacomo's presence and for the numerous tasks entrusted to the student by the Supreme. By order of Manes, they are summoned to shed light on the death of an Olympic rifle champion killed in a firing range. Forced closeness doesn't make things better, while the Supreme senses that Alice has discovered her secret.

The investigation into the tragic accident that occurred to a stunt double during the shooting of a film captures Alice's attention, making her forget an appointment with Claudio. The relationship of love between the two becomes more and more turbulent, while Sandro, who supports her in the inspection, is increasingly fascinated by her. Marco has an important job opportunity that puts him and Lara at a crossroads. While working on the research that Manes has entrusted to her, Alice's unstoppable curiosity leads her to discover an unspeakable truth about the Supreme.