Houston welcomes veterinarians Dr. Blue, Dr. Ross and Dr. Lavigne, who have their hands full with everything from risky surgeries to diagnosing sick chameleons. A car accident brings the practice to a halt as one of the doctors faces a long recovery.

Dr. Ross is back at the clinic, but a check-up with a large per proves to be too much too soon. When pregnant Frenchie goes into early labor, Dr. Lavigne performs an emergency c-section. Dr. Blue plans a Texas outing, to help lift Dr. Ross’s spirits.

While Dr. Blue & Dr. Ross help a client at their goat farm, Dr. Lavigne must save a pup with an obstruction in his intestines and concerned family waiting. Dr. Blue & Dr. Ross compete in a cook-off to see who is the best grill master.

Dr. Ross buys a mobile unit for community outreach and Dr. Blue enlists his brother to help deck it out. Back at the clinic, Dr. Ross examines an iguana for an abscess and Dr. Lavigne helps a paraplegic dachshund get a new set of wheels.

Flooding has sent Houston into a state of emergency. While the clinic takes in displaced animals, Dr. Blue treats a puppy that has contracted a deadly disease from standing water. Dr. Lavigne and Dr. Ross examine a tiger found wandering in a neighborhood.

Dr. Ross performs a life-altering surgery on a sweet pup given a second chance at life, while Dr. Lavigne examines a prickly pet. After treating an injured owl, Dr. Blue joins Dr. Ross on pig farm to examine a cute litter of tiny piglets that are sick.

Dr. Lavigne must remove tumors from an older dog, while Dr. Ross tries to save a rabbit's foot that's been damaged by a dog attack. Before he can compete with Dr. Ross in a puppy-training competition, Dr. Blue visits farm to castrate an aggressive donkey.

The clock is ticking as Dr. Blue performs an emergency C-section on a mother with two puppies stuck in her uterus, while Dr. Ross and Dr. Lavigne work on pets with serious eye issues. The vets test their on-camera skills to create a video for the clinic.