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Jay and Sean visit Portland, Oregon, a town known for its alternative ethos and hipster spirit. From a microbrewery and a small batch whiskey bar to a rum club and a spot for an authentic Spanish coffee, the guys take in the city’s artisanal culture, jump on an old-timey bar bus tour, and check out the town’s oldest strip club. Special guest: The Decemberists’ Chris Funk.

Season 2 ends with Jay and Sean playing bingo, beer pong and virtual golf at the best game bars in the country. They also get heckled at a renaissance fair, test their smarts with comedian Kyle Kinane and strike out with swimsuit model Nina Agdal.

Jay and Sean search for the best hotel bars in the U.S. Comedians Nick Thune and Jen Kirkman appear.

Jay and Sean visit Austin, Texas, a town that embraces the craft cocktail movement while giving it a unique local twist and a dash of downhome Texas charm.

Jay and Sean visit Chicago and learn about booze's mobster roots. They get the Picasso treatment at a neighborhood landmark, take in the comedy scene with Pete Holmes, and get a taste of local music with blues legend Buddy Guy.

Jay and Sean search for the best bar food in America. In San Francisco, they toss dough with a champion pizza maker. In Chicago, they learn the true meaning of going "whole hog"; and in Los Angeles they nearly drown in nacho cheese with comedian Al Madrigal.

Friends and comedians Jay Larson and Sean Patton explore bars featured in Esquire magazine’s annual rundown of the best in the country with stops in Milwaukee, Chicago and San Francisco.

Jay and Sean are back in New York, but this time they’re taking their drinking tour to their old stomping ground: Brooklyn.

Jay and Sean travel the country looking for that which is often overlooked, the best hotel bars in the country. Special guests include comedians Nick Thune and Jen Kirkman.

Jay and Sean visit the Southern California coast, where they find an old stagecoach stop in the mountains of Santa Barbara, a pop-up culinary cocktail bar in a Venice garden and a beach-front dive with ice cold beer. Comedian Bill Burr appears.

Season 2 begins with comedians Jay Larson and Sean Patton getting punch drunk with Nat Faxon in San Francisco.

Jay and Sean visit Louisville and learn there is a lot more than whiskey in bourbon country. They sip a cocktail with a haunted history, go nose-to-tail with char-grilled squirrel, and learn a palate-busting beer lesson from the Brew Dogs.