Can guys and girls ever really be best friends? It's a question Alphonze Fitzhugh and Britani Coberly hear many times--and they always shrug it off. These Northern California teenagers are more like brother and sister, sharing a passion for sports and meeting up with their friends for bonfires in the local vineyards. But like a grape that isn't picked, this friendship withers on the vine. Hidden attraction turns into jealousy, which then sets off a chain reaction of anger and revenge.

Lula Young and Linda Leedom seem like typical moms. They live on a quiet suburban street, raising their families side by side. Lula is a homemaker who volunteers at the fire department, and Linda is a former nurse with a home business as an accountant. Through sickness and heartbreak, Lula and Linda are best friends and perfect neighbors. But looks can be deceiving. To make her dreams come true, one of them will do anything: fraud, arson… even murder.

Josh Drucker is a preacher's son with a calling to the ministry. Andrew Robertson is a bouncer and construction worker with a taste for motorcycles. They never would have met, if Andrew hadn't fallen for Josh's younger sister. What starts out as an unlikely friendship becomes a deep bond, until a tragic event leads to suspicion and revenge. When the smoke clears, two people are dead ... and one is on the way to Death Row.

Two West Virginia girls, best friends since third grade, turn on each other when a third girl transforms their solid duo into an unstable trio. When one of the girls goes missing, police focus in on her BFF and eventually prove that she's the killer.

Growing up in a small Texas town, Misti Mayo and Christine Smith share everything: clothes, music, even teen pregnancy. But a move to the big city introduces them to a new lifestyle and a new group of friends. They find themselves in a spiral of bad decisions and escalating violence. With their backs against the wall, each of the girls has to choose between herself... and her best friend.

A former deejay living in California, inherits money from his wealthy father. The heir’s BFF, a banker, offers to help him manage the windfall, but the two have a falling out that ends up with a showdown, a murder and a manhunt.

At a school for at-risk youth in Illinois, Sarah Kolb rules the hallways. She takes new student Adrianne Reynolds under her wing, showing her the ropes and introducing her to the popular crowd. As the two get closer and closer, people around them start to wonder if they're more than best friends. But in this school, only one of them can be the most popular. Jealousy leads to contempt, and rumors spread like wildfire... until a final showdown after class turns into a deadly confrontation.

He was from the wrong side of the tracks, she was the apple of her parents' eye and had every advantage in life. Together they became unlikely best friends, until another girl, and a secret, come between them. Police in Arizona bear down on one of the BFFs until the truth comes out and the gruesome murder is solved.

Alabama party boys and best friends Butch Hampel and Richard Terry meet while working at the local paper mill. The two are inseparable bachelors and roommates living the good life, until a woman comes between them. When one best friend falls for the other man's wife, all bets are off. It's a violation of an age-old code, a code their friends call "Dude Law." But will this be a crime of passion, or a crime of jealousy?

When retired rodeo champion Bob Huber takes a young, aspiring cowboy named Ryan Bryant under his wing, it seems like a perfect match. The two start running a business and coaching a little league team. Yet slowly but surely, one man begins to chafe under the yoke of their friendship and hatches a plan to rid himself of the other ... forever. In a ruthless competition between the wily older man and the strong young buck, who will win?

Any time best friends turn on each other, it's a tragedy--years of love and trust swept away in a moment of anger, jealousy, or greed. But some cases are so shocking that nobody sees them coming. These are the seven least likely suspects from Season One of I Killed My BFF. Narrated in the voice of murder victim Misti Mayo, this special episode traces the stories of seven killers who fooled everyone... until it was too late.

When two young mothers meet by accident, they seem destined to become best friends. Jamie Dennis is an aspiring writer who spends hours honing her craft. Anne Camp loves playing with Jamie’s children, and she offers to be their babysitter. But this friendship is heading for trouble. Jamie has money problems and needs a quick way to pay the bills. Anne is in a bitter custody battle for her own daughter. Both women will have to make a terrible choice: to save your family, would you sacrifice your best friend?

Dean Allen is a clean-cut carpenter in east Texas, a young man who always follows the rules. Dean befriends a newcomer, Robert Pogue, a butcher who never met a rule he couldn’t break. Dean is drawn to Robert’s fun-loving nature, and the two become best friends. Although only 17, Dean meets and marries Janice, who is five years his senior. But when Janice begins an affair with Robert, the two best friends turn on each other–a showdown that will end in gruesome death.

Gerry Scotti and Barry Feldman are living the good life in Los Angeles. Gerry is a high-powered defense attorney, Barry his brilliant paralegal. They become best friends, each complementing the other's strengths and weaknesses. But there's a dark side to their work, defending drug dealers and other accused criminals. And Barry has a problem, a gambling addiction that already landed him in jail. As the stakes get higher, one of them will do anything to avoid losing it all.