When the school trip vote between Nanette's suggestion of Ballet Russe or Angela's suggestion of "Monster Truck Rally" becomes a tie, Nanette proposes that they set up fund-raisers so whoever raises the most money gets to go on their suggestion. Angela, Gina, Johnny and Gordy decide that a "pet wash" is the best way to raise money. The class goes on a trip to the space museum. Angela brings along her dad's space rock which he found in Utah in 1959.

Angela and her friends join a beginner's ice skating class only to find that not only has Nanette joined as well, but she already knows how to skate; and her show-off moves cause Angela to fall and break her arm. When Angela has to write a poem about someone she admires, she selects her terrier King. When she presents the poem to the class, Mrs. Brinks assumes that she is the subject of Angela's poem. Nanette, meanwhile, writes her poem about Marie Antoinette the French Queen (even though Marie Antoinette was Austrian).

Angela is worried because she did not come up with a topic for her rainforest project, until Mrs. Brinks falls ill, and is replaced by a substitute teacher named Miss. Geraldine "Gerry" Klump. Fortunately for Angela, Ms. Klump is shown to take a shine to her over Nanette. Mr. and Mrs. Manoir hire Geneva Anaconda to carve a sculpture of Nanette. While Nanette is in pose, Angela is ordered around as her personal servant.

Angela starts getting plagued with bad luck claiming they are all "accidents" despite Josephine Praline's insistence that the jinx is a natural result of not being "touched by an angel" and tries to persuade Angela into being nice to Nanette, despite Josephine herself not finding any good qualities in Nanette. Nanette's pampered poodle Ooh La La goes missing and Angela finds him in her backyard - in a love affair with her own terrier dog King!

When Gordy expresses an interest in football, through horticulture, Coach Rhineheart enlists a few good men (Mark and Derek Anaconda) to help his son grasp the sport's finer points. Tapwater Springs Elementary School is visited by Prince Abdul Khalid Jabalasaldin, a wealthy and snobbish prince from Saudi Arabia. Angela wrangles her way into giving the prince a tour of the school where he spends the day mooning over Nanette and getting on Johnny Abatti's nerves.

When Nanette is bedridden with the flu January and Karlene latch onto Angela who is given the job of leader of the spring fling contest and try to bribe her into picking them as her two helpers in order to remain "somebodies" rather than "nobodies". The only episode set in a framing device, Angela recalls to Josephine Praline how Gina Lash trusted Angela to look after her pet turtle Sheldon but lost him after feeding him too many carrots and bought a new lookalike turtle to replace him.

Angela and Nanette each get new and nearly identical trench coats. When Angela gets Nanette's coat by mistake, she also finds herself in possession of Nanette's personal diary. King eats Angela's math homework after it gets covered in bacon grease. Knowing that the truth is clichéd and far-fetched, Angela makes up a story about her dad being sick with some kind of a brain disease.

When Angela makes a mistake in a grammar game, saying, "I love Bob and Hot Chocolate" instead of "Bob and I love Hot Chocolate," Nanette immediately spreads a rumour that Angela likes "Bob." Uncle Nicky and Nona Abatti have a feud with the people from Sabatto's Pizza, their rival pizzeria.

Angela and Nanette become stuck together by bubble gum by their hair. When Nanette bitterly rejects the idea of having the gum hacked out of her perfectly curled hair, she and Angela have to put up with being stuck together. When Nanette insists that her poodle's purebred status makes her more loyal, Angela puts this theory to test by luring him away from Nanette's estate and into the Anaconda's backyard. All goes well until Grandma Lou visits with Barney, her new pet alligator.

Angela has been looking forward to joining her father and brothers on their annual fishing trip. However, when a new invention causes him injuries, Angela is stuck going on the trip with Mark and Derek who force her to do all of the dirty work and won't even let her fish. Gina has no interest in the annual class relay race until she finds out the clue to the top secret prize is initialed M.B. (as in Mapperson's Bakery).

Because of Baby Lulu, Angela gets poison ivy, scares off her friends, and misses "All-Creatures-Great-and-Small-Week" at school. The final straw comes when Lulu releases Angela's butterfly from captivity. When news gets out that Johnny and his parents are moving out of Tapwater Springs, Angela and Nanette throw him competing goodbye parties.

Angela finds herself trapped in the boys' bathroom. Uncle Nicky is doing community service by taking everyone's garbage. Angela and the others enjoy riding in the truck. But Nanette Manior is determined to spoil their fun.

Mr. Mapperson holds a contest to find a new face for his company's delivery truck. Though Angela and Nanette naturally compete the hardest out of everyone, are either of them who Mr. Mapperson truly has in mind? Angela is initially embarrassed over the prospect of a father-daughter hoedown, until the competition turns out to be Howell Manior and Nanette, who have won the dance for two years straight. Now it's a Hoedown Show-Down between the dads and daughters.

Mrs. Brinks' class is learning multiplication. While Angela, with help from Gina, breezes through the lessons, Nanette struggles much to everyone's surprise, and Angela's delight. But the tables turn when Angela gets too cocky and Nanette enlists Gina's help with the promise of free food. Mrs. Brinks is appalled by Angela's true essence of her in art class and unfairly scolds her, so Angela doctors it later much to her classmates' delight. On the way home, Angela realizes that she accidentally left it on her desk instead of her test.

Angela has many qualities that none of her family members do, causing her to feel alienated from the Anaconda family, so she sets out to find who she really is related to. When Johnny gets a new bunk bed, Angela takes advantage of his sleepover invitation in hopes of getting a good night sleep.

Angela is so excited about wearing her new 'highway-worker-orange' windbreaker to school she completely forgets that it is St. Patrick's Day. According to Tapwater Springs' tradition you can pinch anyone not wearing green and when Angela arrives at school that morning everyone in her class can hardly wait until recess time to take advantage of Angela's forgetfulness. Angela becomes Nanette's understudy for Mrs. Brinks' "Miss Manners the Musical". Knowing that Nanette would never give up the limelight, Angela forgoes her duties. But when Nanette catches a cold and Angela's power smoothies do more harm than good, it looks like the limelight is Angela's for the taking.

Johnny and Angela get to run the school store. When Johnny becomes sick, Nanette steps in to fill his place, much to Angela's dismay. The prospect of a bad picture day haircut leads Angela to "borrow" her brother's autographed baseball hat. When the hat gets confiscated and claimed by Nanette, Angela embarks on a series of deals to get it back.

Geneva's creative block is taking a toll on her skills as a mom. After commandeering Angela's homework (resulting in an F), she gives up art and devotes her time into being the perfect mother. But is all the fresh-squeezed orange juice, plastic wrapped furniture, and handmade clothes worth it if nobody is happy, especially Geneva? Because of all the commendation letters from Mrs. Brinks, Nanette gets moved up to the fourth grade. In a fit of transference, Angela takes Nanette's place as Mrs. Brinks' favorite student. However, as Mrs. Brinks' attention becomes unbearable, Angela begins to wonder if having Nanette around isn't as bad as she thought.

Looking to confirm once and for all that Mr. and Mrs. Brinks are weekend nudists, Angela and her friends attempt to rebuild their treehouse higher and higher until it surpasses the fence and Gordy's topiary, thus assuring them the best seats in the house. Angela comes down with Pink Eye and gets to wear an eyepatch. Not to be outdone, Nanette shows up the next day in a wheelchair, claiming that Angela stepped on and crushed her dancing toe; this not only reassures her popularity, but also Angela's servitude at Mrs. Brinks' insistence.

After Josephine teaches the class about Ash Wednesday, Nanette, wanting her memory to live on for eternity, suggests that the entire class participate in sacrificing something for forty days. While Angela gives up imagining things about other people, Nanette embarks on a superficial vow of poverty. Sherman the class chicken escapes his box and Angela convinced Mrs. Jenerette the school crossing guard to help get him back, much to Nanette's inconvenience. As a result, the beloved crossing guard is fired at Mrs. Manior's whim. Wracked with guilt, Angela helps Mrs. Jenerette try to get re-employed.

Angela goes on a chore strike when she realizes that her allowance is the lowest in town. Gina's heart seemingly has gone to Jimmy Jamal, much to Gordy's deep dismay. All hope seems lost until Angela discovers that Gina and Jimmy's affair rests on not what goes on in the latter's heart, but his lunchbox.

"Babble Balls" were all the rage in Tapwater Springs--until Angela had enough money buy one. Now she comes to learn from Nanette and the other kids that it's "Bug Thugs" which are currently 'da bomb'. Grandma Lou comes for a visit and Angela goes to great lengths to make sure they room together. But between the boring stories, the snoring, and waking up face to face with Grandma Lou's detachable leg. Angela's dream roommate turns out to be a nightmare.

Gina Lash comes to Angela's house for a sleepover. However, things go out of plan when Angela's family starts paying more attention and idolism to Gina rather than Angela herself. Distracted by an orange sash and delusions of grandeur, Angela volunteers for hall monitor duties, and quickly learns of its drawbacks. This is especially true when she incurs the wrath of Nanette, whom she cites for littering.

Josephine Praline reveals that her mother has agoraphobia. Angela tries to use this as an excuse to avoid not only school, but Mrs. Brinks's chalk erasers. Angela misses her chance to return a copy of Happy Hoppy Bunny to the library and not get fined. Angela tries all attempts to sneak the book back into the library without either Miss Yamagotchi or Nanette noticing.

After Karlene fails to buy a hat made of real fur, January and Nanette instantly break off their friendship with her. A shocked Karlene then starts constantly leaning on Angela and co. and they invite Karlene into their gang. However, it is unclear whether Karlene is true friends with Angela or not. Uncle Nicky and Nona decide to make a commercial to attract more people to Abatti's Pizza. Who will be the child actor stars in the new commercial: Angela, Gina, Johnny and Gordy or Nanette, January and Karlene?

Angela accidentally invents a new swinging craze. However, Nanette takes credit for it and names it the "Nanette Lock". The people of Tapwater Springs have to design floats and everyone, except Gordy, is finding this easy.