Angela and her friends join a beginner's ice skating class only to find that not only has Nanette joined as well, but she already knows how to skate; and her show-off moves cause Angela to fall and break her arm. When Angela has to write a poem about someone she admires, she selects her terrier King. When she presents the poem to the class, Mrs. Brinks assumes that she is the subject of Angela's poem. Nanette, meanwhile, writes her poem about Marie Antoinette the French Queen (even though Marie Antoinette was Austrian).

Angela looks forward to spending Take Your Kids to Work Day helping her father Bill with his inventions. Instead, she assists her father at his day job as a travelling salesman selling expandable foam. Jimmy Jamal goes away and trusts Angela to keep his "Slamboy" game for him until he returns. However, Nanette takes the batteries, causing Jimmy's saved game to be lost, and Angela must get Jimmy's game back.

Angela is not looking forward to the annual bicycle race. While she's stuck with her brother's hand me down bikes, Nanette rides the best bikes money can buy, and naturally rides rings around her and the competition. This year seems to be no different, until Angela stumbles upon an unidentifiable wallet containing enough money to buy a top quality bike. Tapwater Springs erupts into uproar after the Manoirs have several of their possessions stolen from them.

When the school trip vote between Nanette's suggestion of Ballet Russe or Angela's suggestion of "Monster Truck Rally" becomes a tie, Nanette proposes that they set up fund-raisers so whoever raises the most money gets to go on their suggestion. Angela, Gina, Johnny and Gordy decide that a "pet wash" is the best way to raise money. The class goes on a trip to the space museum. Angela brings along her dad's space rock which he found in Utah in 1959.

Angela is the first to meet the new neighbours, particularly a boy named Stuart Wu. He seems cool at first, and Angela arranges for him to meet her friends. As she helps Stu unpack, he reveals himself as prone to being rude. After a water main bursts under the Anaconda house, Angela develops a devastatingly awful case of insomnia. Her friends try various schemes to get her sleep, each of which end disastrously.

Angela and Gordy are partnered for the school dance. When Gordy proves himself to be a dancing god, Connie Brinks offers the two of them a chance to dance on his local television show. Angela is all for it, until the fame goes to Gordy's head and he transforms into the ultimate diva: Gordy Glitterdust. Angela hits it off well with her new "youth companion" Raven Schwartz, an art student in one of Geneva's classes. Mark ultimately comes to be smitten with Raven and the two go steady, much to the chagrin of not only Angela, but Derek as well.

Jimmy Jamal's obsession with Super Beetle takes a turn for the annoying when he begins to dress and act like him at school. Johnny tries to get him to snap out of it, only to come back as his sidekick Crazy Cricket the next day. When Sherman, the class chicken goes missing and Angela gets the blame, it's up to Johnny and Jimmy to either save the day or hang up their capes for good. To liven up her show-and-tell reports, Angela brings in Mr. Mooey, a cow puppet. Between Mr. Mooey's caustic sense of humor and cow related puns, he proves to be a hit with Mrs. Brinks' class, so much so to the point where Angela begins to find herself overshadowed and ignored by everyone around her.

Angela exploits her friends when her new dog walking job becomes more than she had bargained for. At the book mobile, Bunny Manoir attempts to have The Wizard of Oz banned on the grounds that it promotes wizardry and witchcraft.

The class each get a pen pal, and Angela gets Marie Antoinette from France as hers. When Marie Antoinette's letters turn malicious, Angela begins to suspect Nanette is responsible. Mr. Tastee Twirl hosts a talent contest which the winner will get to ride around in the truck and ring the bell. Angela and Her Band-Aconda compete against Nanette's girl group, the Ooh La La La Lahs.

The class picks Secret Santas for Christmas. When Angela picks Nanette much to her chagrin, she must decide between buying a bottle of "toilet water" or a toaster for French toast. Uncle Nicky accidentally loses Gina Lash's great-grandmother's menorah in a game of dreidel and Angela, Gina, Johnny and Gordy go on a crusade from place to place to retrieve the menorah in time for the Chanukah party.

At the zoo, Angela is chosen to do an assignment on the weasel, an animal that hasn't been seen since 1987. At the museum, the mummy of King Tutankhamun falls on Angela, giving her what appears to be bad luck.

Josephine Praline lends Angela her collection of insects to mind for her. However, Angela may not be capable of such a big responsibility. Angela starts practising using a pogostick, something which she is very bad at.

After getting into an ice skating accident, Angela becomes furious when everyone, even her friends, start joking with her because of it. She hides in the toilets and writes a list of jibes about everyone "who annoyed her" on a roll of toilet paper. When Nanette discovers the list, she starts blackmailing Angela into doing chores for her with it. The Anacondas get a Parisienne foreign exchange student called CiCi LeCreme who becomes friends with Nanette yet refuses to invite CiCi to her own house (under claims that their house is being fumigated for fleas).

After Karlene fails to buy a hat made of real fur, January and Nanette instantly break off their friendship with her. A shocked Karlene then starts constantly leaning on Angela and co. and they invite Karlene into their gang. However, it is unclear whether Karlene is true friends with Angela or not. Uncle Nicky and Nona decide to make a commercial to attract more people to Abatti's Pizza. Who will be the child actor stars in the new commercial: Angela, Gina, Johnny and Gordy or Nanette, January and Karlene?

Mr. Mapperson holds a contest to find a new face for his company's delivery truck. Though Angela and Nanette naturally compete the hardest out of everyone, are either of them who Mr. Mapperson truly has in mind? Angela is initially embarrassed over the prospect of a father-daughter hoedown, until the competition turns out to be Howell Manior and Nanette, who have won the dance for two years straight. Now it's a Hoedown Show-Down between the dads and daughters.

Angela and Nanette become stuck together by bubble gum by their hair. When Nanette bitterly rejects the idea of having the gum hacked out of her perfectly curled hair, she and Angela have to put up with being stuck together. When Nanette insists that her poodle's purebred status makes her more loyal, Angela puts this theory to test by luring him away from Nanette's estate and into the Anaconda's backyard. All goes well until Grandma Lou visits with Barney, her new pet alligator.

When Gordy expresses an interest in football, through horticulture, Coach Rhineheart enlists a few good men (Mark and Derek Anaconda) to help his son grasp the sport's finer points. Tapwater Springs Elementary School is visited by Prince Abdul Khalid Jabalasaldin, a wealthy and snobbish prince from Saudi Arabia. Angela wrangles her way into giving the prince a tour of the school where he spends the day mooning over Nanette and getting on Johnny Abatti's nerves.

Angela is worried because she did not come up with a topic for her rainforest project, until Mrs. Brinks falls ill, and is replaced by a substitute teacher named Miss. Geraldine "Gerry" Klump. Fortunately for Angela, Ms. Klump is shown to take a shine to her over Nanette. Mr. and Mrs. Manoir hire Geneva Anaconda to carve a sculpture of Nanette. While Nanette is in pose, Angela is ordered around as her personal servant.

When Angela makes a mistake in a grammar game, saying, "I love Bob and Hot Chocolate" instead of "Bob and I love Hot Chocolate," Nanette immediately spreads a rumour that Angela likes "Bob." Uncle Nicky and Nona Abatti have a feud with the people from Sabatto's Pizza, their rival pizzeria.

When Nanette is bedridden with the flu January and Karlene latch onto Angela who is given the job of leader of the spring fling contest and try to bribe her into picking them as her two helpers in order to remain "somebodies" rather than "nobodies". The only episode set in a framing device, Angela recalls to Josephine Praline how Gina Lash trusted Angela to look after her pet turtle Sheldon but lost him after feeding him too many carrots and bought a new lookalike turtle to replace him.

Angela accidentally invents a new swinging craze. However, Nanette takes credit for it and names it the "Nanette Lock". The people of Tapwater Springs have to design floats and everyone, except Gordy, is finding this easy.

At the town's annual Save the Manatees auction, local hero Astronaut Bob offers himself as a last minute prize. Angela, having lost her chance to win a space helmet to Nanette, is the highest bidder. But Nanette schemes her way into Astronaut Bob's heart and manages to thwart any and all of Angela's attempts to have fun. An unscrewed pepper shaker lid prank against Mark and Derek backfires against Angela and she has to go to school with a nose full of itchy pepper.

Angela tries to find the perfect food in order to trade off her liverwurst sandwiches. Nothing she tries seems to work until a can of Squiggly Cheese changes her lunchtime fortunes change for the better. Gordy is recruited into the Junior Ranger-ettes by Angela and Gina in their efforts to keep January and Karlene from electing Nanette as troop leader.

After taking Grandma Lou to Abatti's Pizza for lunch, it is revealed that Grandma Lou and Nona Abatti have had a lifelong feud and even go so far as to prevent Angela and Johnny from being friends. Nanette is unsurprisingly chosen as head anchor when Mrs. Brinks' class is chosen to do a newscast for the town's community-access channel. Angela, by contrast, is given the farm report. All seems lost until one of Farmer Jangels' goats gives birth to six kids.

Gina is one gold star away from being crowned Q&A Queen and defeating Nanette in the process. When Gina eats too much the night before the final competition, the crown is as good as Nanette's, until Angela stumbles upon the teacher's edition of their textbook. Angela would love to become the new Q&A Queen though in her heart she knows that Gina truly deserves the coronation. Angela and her friends win free tickets to the movie Interstellar Mega Giants vs. Mechanataur, but obstacles prevent her from finding the best seats in the theatres.

On Halloween night, Angela decides to give Mark and Derek a scare. When the lights start flickering and strange, howling noises echo through Angela's garage, Angela wonders if her garage is really haunted or if it is just Mark and Derek playing usual tricks.

After looking at an eyelash under a microscope and spotting a microbe on it, Gordy becomes mysophobic and refuses to leave the house. After dropping out of "Camp Connie" Angela, Gina, Johnny and Gordy stay at the Anaconda's home which they rename as "Camp Anaconda". Camp Anaconda however seems to be even worse, as Angela's brothers won't let them do anything at all.

Football season is cancelled when Coach Rhinehart loses his voice. Not only does this provide Mark and Derek with ample time to torture Angela, but the team loses the next game (courtesy of Gordy Rinehart’s words-of-wisdom). Angela must find a way to get the coach healthy again. When Johnny finds that he has grown his "first ever Abatti chest hair", Uncle Nicky begins to pressure Johnny into manhood. After a "crash course in coolness", Johnny's reemergence as "John-O" slowly begins to disgust Angela and her friends.

The evil Jiggly Fruit mascot Jiggly James announces that Jiggly Fruit will be replaced by "New Jiggly Fruit" which tastes disgusting. Angela, Gina and even Mrs Brinks go out of their way to protest against New Jiggly Fruit and bring back old Jiggly Fruit, even going so far as to replace Mrs. Brinks' lectures with protest periods and masquerading as the "Jiggly Angels". Johnny gets into an accident preparing for the soapbox race car derby. Disappointed with himself, Johnny is convinced he has lost his racing magic and Angela must take the wheel.

Mrs. Lash takes Angela and her friends to the beach. The four of them are thrilled to be out of school and on the shore; until Nanette and her posse show up to spoil their fun. To make matters worse, Mrs. Brinks is a volunteer lifeguard. Angela and her friends must save Mark and Derek's softball from a possessive neighbourhood dog named Carnivorous.

After one unwarranted punishment from Mrs. Brinks too many, Angela decides to give in and become the troublemaker everyone thinks she is. As master troublemakers, Mark and Derek become Angela's prank consultants, and the school is turned on its ear. At Astronaut Bob's space camp, everyone has high hopes of becoming a junior astronaut. Since there is only room for one junior astronaut, Astronaut Bob puts the kids through a series of competitions.

Bill and Geneva are aghast when they hear Baby Lulu cursing and all evidence seems to point towards Angela as the culprit. Angela and her friends find out that the "funny photos" section of their town paper is not only humorous, but profitable. When their funny faces fail, the four of them orchestrate "accidents" hoping to cash in on the funny photo reward.

At the library book sale, Nonna Abatti stumbles upon "Cry of the She-Wolf", a feminist manifesto. A few chapters in, Nonna comes to the conclusion that as a woman, she has been taken advantage of and closes Abatti's Pizzeria for good. A jubilee is planned in honor of Mrs. Brinks' teaching career, and Angela is in charge of finding tribute acts. The problem is that none of her students have any fond memories of her teaching. When all hope seems lost, Angela stumbles upon an old yearbook with an inscription of "love always" from Corey Cray, a soap opera idol and former student of Mrs. Brinks.

When a snowy day cancels classes at Tapwater Elementary, Angela and her friends spend their snow day trying to find the perfect place to toboggan. Angela's tendency to daydream causes her to get hit with a hockey puck, thus instilling a fear of hockey altogether. To help Angela conquer her fear of ice hockey, her friends decide to each conquer their respective fears.

A class trip to OceanWorld prompts Angela to take an interest in marine biology. The Anacondas apply to pose inside a giant glass cabinet at the local museum to show a "modern day family". It seem to go well, until people begin seeing the family's more embarrassing habits.

After almost stealing burgers from Budgie Burger, Mark and Derek become employed to avoid getting criminal records and earn enough wage to pay Kimmy the manager back. The oldest oak tree in Tapwater Springs is slated to be torn down in favor of a shopping mall at Mr. Manior's whim. When Angela decides to climb the tree and can't come down, she finds herself unwittingly leading a protest movement to save the tree.

Angela is sick of Mark and Derek forcing her into smelling their dirty laundry and looks to Coach Rhinehart for some martial arts training. After Angela learns to "flip" people even her friends avoid her in fear, thinking she is a bully. Angela accidentally steals a pair of "Orange Stompers" from the shoe shop and faces all of the obstacles and consequences to smuggle the stompers back into the shop and retrieve her old shoes.

Johnny's ill-fated attempt to save his sock puppet, Sir Ducksworthy, lands him in the hospital. Now more than ever, Johnny needs Sir Ducksworthy by his side. Angela tries to make a replacement puppet, which causes bad luck. To show her solidarity with local broccoli farmers, Josephine has taken a vow of silence to protest the ongoing drought. Sensing that Angela is unable to answer a question in class, Gina blurts out that Angela is also taking a vow of silence to protest poor teacher wages. Not only does keeping quiet become more difficult than it seems, a recent rainstorm releases Josephine from her vows; and she can think of many ways to use her voice that may get Angela talking.

Geneva gets into a fight with her friend Cokie Fowler. In order to avoid a similar fate, Angela and Gina become closer than ever, a move that strains their friendship. They stop speaking to each other which worsens the situation because they can't discuss their problems. As part of an opening day promotion, a new toy store is raffling off a motorized car to whoever wins. Gina, Johnny and Gordy leave their tickets with Angela, who wins the raffle.

Angela starts getting plagued with bad luck claiming they are all "accidents" despite Josephine Praline's insistence that the jinx is a natural result of not being "touched by an angel" and tries to persuade Angela into being nice to Nanette, despite Josephine herself not finding any good qualities in Nanette. Nanette's pampered poodle Ooh La La goes missing and Angela finds him in her backyard - in a love affair with her own terrier dog King!