Returning to her hometown after an 8-year absence, Nora Schweihs is back in Chicago to investigate the mysterious circumstances surrounding the burial of her Father, alleged hit man, Frank "The German" Schweihs. Pia Rizza, daughter of one of Chicago's most hated government informants, is focusing on raising her daughter while her friend, Christina Scoleri, the scrappy daughter of mob thief and safecracker, Raymond Janek, is trying to navigate the minefield of a divorce. Leah DeSimone lives at home with her "truck driver" father, Billy "The Wolf" DeSimone while Renee Fecarotta Russo struggles with issues of trust following the death of her beloved Uncle "Big John." The ladies try to put their shared pasts behind them, hoping to bond during a girls' night out. But things go terribly wrong as past offenses, long-held secrets, and simmering resentments bubble violently to the surface.

New alliances begin to take shape as all the ladies attempt to move on with their lives, one way or another. Pia is trying to embark on a new career and Christina realizes that she needs to make some serious decisions about living with her ex.

Despite their differences, all the women finally gather for Leah's mother breast cancer walk. When Leah requests the group to stay together, Pia and Renee create more tension by distancing themselves from the group. This does not sit well with Leah.